Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313550094> ?p ?o ?g. }
- W4313550094 endingPage "105936" @default.
- W4313550094 startingPage "105936" @default.
- W4313550094 abstract "Osteoarthritis (OA) is a trauma-/age-related degenerative disease characterized by chronic inflammation as one of its pathogenic mechanisms. Mulberroside A (MA), a natural bioactive withanolide, demonstrates anti-inflammatory properties in various diseases; however, little is known about the effect of MA on OA. We aim to examine the role of MA on OA and to identify the potential mechanisms through which it protects articular cartilage. In vitro, MA improved inflammatory response, anabolism, and catabolism in IL-1β-induced OA chondrocytes. The chondroprotective effects of MA were attributed to suppressing the MAPK, NF-κB, and PI3K-AKT-mTOR signaling pathways, as well as promoting the autophagy process. In vivo, intra-articular injection of MA reduced the cartilage destruction and reversed the change of anabolic and catabolic-related proteins in destabilized medial meniscus (DMM)-induced OA models. Thus, the study indicates that MA exhibits a chondroprotective effect and might be a promising agent for OA treatment." @default.
- W4313550094 created "2023-01-06" @default.
- W4313550094 creator A5008561132 @default.
- W4313550094 creator A5012457731 @default.
- W4313550094 creator A5013206062 @default.
- W4313550094 creator A5026405111 @default.
- W4313550094 creator A5035633948 @default.
- W4313550094 creator A5036899667 @default.
- W4313550094 creator A5043136018 @default.
- W4313550094 creator A5048167307 @default.
- W4313550094 creator A5080746380 @default.
- W4313550094 creator A5080805747 @default.
- W4313550094 creator A5085340509 @default.
- W4313550094 date "2023-02-01" @default.
- W4313550094 modified "2023-10-16" @default.
- W4313550094 title "Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways" @default.
- W4313550094 cites W1115057921 @default.
- W4313550094 cites W1950911242 @default.
- W4313550094 cites W1971496705 @default.
- W4313550094 cites W1985941510 @default.
- W4313550094 cites W1993990835 @default.
- W4313550094 cites W2003867975 @default.
- W4313550094 cites W2006566638 @default.
- W4313550094 cites W2026026508 @default.
- W4313550094 cites W2042938039 @default.
- W4313550094 cites W2043344789 @default.
- W4313550094 cites W2048150179 @default.
- W4313550094 cites W2051155342 @default.
- W4313550094 cites W2053188169 @default.
- W4313550094 cites W2062106607 @default.
- W4313550094 cites W2065569607 @default.
- W4313550094 cites W2086619532 @default.
- W4313550094 cites W2087375532 @default.
- W4313550094 cites W2087958138 @default.
- W4313550094 cites W2094183877 @default.
- W4313550094 cites W2094371980 @default.
- W4313550094 cites W2099427592 @default.
- W4313550094 cites W2108888253 @default.
- W4313550094 cites W2126674282 @default.
- W4313550094 cites W2274971583 @default.
- W4313550094 cites W2293808269 @default.
- W4313550094 cites W2507683743 @default.
- W4313550094 cites W2560355162 @default.
- W4313550094 cites W2596302024 @default.
- W4313550094 cites W2604174049 @default.
- W4313550094 cites W2742147437 @default.
- W4313550094 cites W2764075483 @default.
- W4313550094 cites W2767813923 @default.
- W4313550094 cites W2805257547 @default.
- W4313550094 cites W2883019022 @default.
- W4313550094 cites W2889131448 @default.
- W4313550094 cites W2891184420 @default.
- W4313550094 cites W2898585678 @default.
- W4313550094 cites W2900550641 @default.
- W4313550094 cites W2915488153 @default.
- W4313550094 cites W2947624537 @default.
- W4313550094 cites W2961082130 @default.
- W4313550094 cites W2981289337 @default.
- W4313550094 cites W2992672711 @default.
- W4313550094 cites W3003221459 @default.
- W4313550094 cites W3007541218 @default.
- W4313550094 cites W3046230663 @default.
- W4313550094 cites W3097157407 @default.
- W4313550094 cites W3107991803 @default.
- W4313550094 cites W3107998825 @default.
- W4313550094 cites W3112090459 @default.
- W4313550094 cites W3113653410 @default.
- W4313550094 cites W3128044437 @default.
- W4313550094 cites W3133530486 @default.
- W4313550094 cites W3139450778 @default.
- W4313550094 cites W3175873868 @default.
- W4313550094 cites W3184506046 @default.
- W4313550094 cites W3196108076 @default.
- W4313550094 cites W3208697890 @default.
- W4313550094 cites W3215497458 @default.
- W4313550094 cites W4206209892 @default.
- W4313550094 cites W4211069396 @default.
- W4313550094 cites W4283742640 @default.
- W4313550094 cites W4288884897 @default.
- W4313550094 cites W4310490265 @default.
- W4313550094 doi "https://doi.org/10.1016/j.isci.2023.105936" @default.
- W4313550094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36698724" @default.
- W4313550094 hasPublicationYear "2023" @default.
- W4313550094 type Work @default.
- W4313550094 citedByCount "1" @default.
- W4313550094 countsByYear W43135500942023 @default.
- W4313550094 crossrefType "journal-article" @default.
- W4313550094 hasAuthorship W4313550094A5008561132 @default.
- W4313550094 hasAuthorship W4313550094A5012457731 @default.
- W4313550094 hasAuthorship W4313550094A5013206062 @default.
- W4313550094 hasAuthorship W4313550094A5026405111 @default.
- W4313550094 hasAuthorship W4313550094A5035633948 @default.
- W4313550094 hasAuthorship W4313550094A5036899667 @default.
- W4313550094 hasAuthorship W4313550094A5043136018 @default.
- W4313550094 hasAuthorship W4313550094A5048167307 @default.
- W4313550094 hasAuthorship W4313550094A5080746380 @default.
- W4313550094 hasAuthorship W4313550094A5080805747 @default.
- W4313550094 hasAuthorship W4313550094A5085340509 @default.