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• W4313550136 abstract "L-piperazic acid (L-Piz) is one of components in many bioactive compounds synthesized by Streptomyces spp. Therefore, it is very important to develop a sustainable and eco-friendly bioprocess to produce L-Piz from renewable glucose. In this study, it was found that the engineered Aureobasidium melanogenum DFAK-ArgB6 strain overexpressing the ArgB gene encoding N-acetylglutamate kinase could produce 3.0 g/L L-Piz from glucose during the fed-batch fermentation. The yield was 55.6 mg L-Piz/g of glucose and the productivity was 24.8 mg/L/h. This was the highest amount of L-Piz produced by microorganisms so far. Finally, the partially purified L-Piz had purity of 86.4%." @default.
• W4313550136 created "2023-01-06" @default.
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• W4313550136 date "2023-03-01" @default.
• W4313550136 modified "2023-10-18" @default.
• W4313550136 title "Overproduction of L-piperazic acid by overexpression of ArgB gene in Aureobasidium melanogenum DFAK1" @default.
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• W4313550136 doi "https://doi.org/10.1016/j.procbio.2022.12.035" @default.
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