FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313555589> ?p ?o ?g. }

• W4313555589 abstract "Abstract Histone deacetylase (HDAC) is a kind of protease that modifies histone to regulate gene expression, and is usually abnormally activated in tumors. The approved pan-HDAC inhibitors have demonstrated clinical benefits for patients in some hematologic malignancies. Only limited therapeutic success in breast cancer has been observed in clinical trials. In this study, we declare that pan-HDAC inhibitors targeting NEDD9-FAK pathway exacerbate breast cancer metastasis in preclinical models, which may severely impede their clinical success. NEDD9 is not an oncogene, however, it has been demonstrated recently that there are high level or activity changes of NEDD9 in a variety of cancer, including leukemia, colon cancer, and breast cancer. Mechanistically, pan-HDAC inhibitors enhance H3K9 acetylation at the nedd9 gene promoter via inhibition of HDAC4 activity, thus increase NEDD9 expression, and then activate FAK phosphorylation. The realization that pan-HDAC inhibitors can alter the natural history of breast cancer by increasing invasion warrants clinical attention. In addition, although NEDD9 has been reported to have a hand in breast cancer metastasis, it has not received much attention, and no therapeutic strategies have been developed. Notably, we demonstrate that FAK inhibitors can reverse breast cancer metastasis induced by upregulation of NEDD9 via pan-HDAC inhibitors, which may offer a potential combination therapy for breast cancer." @default.
• W4313555589 created "2023-01-06" @default.
• W4313555589 creator A5006459982 @default.
• W4313555589 creator A5029508998 @default.
• W4313555589 creator A5046393760 @default.
• W4313555589 creator A5060316862 @default.
• W4313555589 creator A5060848619 @default.
• W4313555589 creator A5063800558 @default.
• W4313555589 creator A5067595213 @default.
• W4313555589 creator A5089348951 @default.
• W4313555589 date "2023-01-06" @default.
• W4313555589 modified "2023-10-12" @default.
• W4313555589 title "Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression" @default.
• W4313555589 cites W1897784532 @default.
• W4313555589 cites W1941548156 @default.
• W4313555589 cites W1964473274 @default.
• W4313555589 cites W1967018540 @default.
• W4313555589 cites W1968428572 @default.
• W4313555589 cites W1982280065 @default.
• W4313555589 cites W1983607673 @default.
• W4313555589 cites W1988616072 @default.
• W4313555589 cites W1989854110 @default.
• W4313555589 cites W1991086228 @default.
• W4313555589 cites W1998957807 @default.
• W4313555589 cites W1999782534 @default.
• W4313555589 cites W2009707750 @default.
• W4313555589 cites W2013870404 @default.
• W4313555589 cites W2018460886 @default.
• W4313555589 cites W2020649532 @default.
• W4313555589 cites W2028236537 @default.
• W4313555589 cites W2036694038 @default.
• W4313555589 cites W2038311942 @default.
• W4313555589 cites W2047530075 @default.
• W4313555589 cites W2061820978 @default.
• W4313555589 cites W2063507014 @default.
• W4313555589 cites W2082833890 @default.
• W4313555589 cites W2089189552 @default.
• W4313555589 cites W2096896583 @default.
• W4313555589 cites W2114913135 @default.
• W4313555589 cites W2117691193 @default.
• W4313555589 cites W2149419525 @default.
• W4313555589 cites W2157293274 @default.
• W4313555589 cites W2159963557 @default.
• W4313555589 cites W2166311434 @default.
• W4313555589 cites W2181788738 @default.
• W4313555589 cites W2408743616 @default.
• W4313555589 cites W2479346408 @default.
• W4313555589 cites W2510601685 @default.
• W4313555589 cites W2511667040 @default.
• W4313555589 cites W2521868444 @default.
• W4313555589 cites W2757067487 @default.
• W4313555589 cites W2793181604 @default.
• W4313555589 cites W2804042947 @default.
• W4313555589 cites W2808128543 @default.
• W4313555589 cites W2892712216 @default.
• W4313555589 cites W2963709649 @default.
• W4313555589 cites W3215180146 @default.
• W4313555589 cites W4200495356 @default.
• W4313555589 cites W4280537797 @default.
• W4313555589 cites W4280539088 @default.
• W4313555589 cites W650407107 @default.
• W4313555589 doi "https://doi.org/10.1038/s41392-022-01221-6" @default.
• W4313555589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36604412" @default.
• W4313555589 hasPublicationYear "2023" @default.
• W4313555589 type Work @default.
• W4313555589 citedByCount "3" @default.
• W4313555589 countsByYear W43135555892023 @default.
• W4313555589 crossrefType "journal-article" @default.
• W4313555589 hasAuthorship W4313555589A5006459982 @default.
• W4313555589 hasAuthorship W4313555589A5029508998 @default.
• W4313555589 hasAuthorship W4313555589A5046393760 @default.
• W4313555589 hasAuthorship W4313555589A5060316862 @default.
• W4313555589 hasAuthorship W4313555589A5060848619 @default.
• W4313555589 hasAuthorship W4313555589A5063800558 @default.
• W4313555589 hasAuthorship W4313555589A5067595213 @default.
• W4313555589 hasAuthorship W4313555589A5089348951 @default.
• W4313555589 hasBestOaLocation W43135555891 @default.
• W4313555589 hasConcept C104317684 @default.
• W4313555589 hasConcept C121608353 @default.
• W4313555589 hasConcept C126322002 @default.
• W4313555589 hasConcept C2778305200 @default.
• W4313555589 hasConcept C2779013556 @default.
• W4313555589 hasConcept C2781018059 @default.
• W4313555589 hasConcept C29537977 @default.
• W4313555589 hasConcept C502942594 @default.
• W4313555589 hasConcept C530470458 @default.
• W4313555589 hasConcept C55493867 @default.
• W4313555589 hasConcept C64927066 @default.
• W4313555589 hasConcept C71924100 @default.
• W4313555589 hasConcept C86803240 @default.
• W4313555589 hasConceptScore W4313555589C104317684 @default.
• W4313555589 hasConceptScore W4313555589C121608353 @default.
• W4313555589 hasConceptScore W4313555589C126322002 @default.
• W4313555589 hasConceptScore W4313555589C2778305200 @default.
• W4313555589 hasConceptScore W4313555589C2779013556 @default.
• W4313555589 hasConceptScore W4313555589C2781018059 @default.
• W4313555589 hasConceptScore W4313555589C29537977 @default.
• W4313555589 hasConceptScore W4313555589C502942594 @default.
• W4313555589 hasConceptScore W4313555589C530470458 @default.
• W4313555589 hasConceptScore W4313555589C55493867 @default.

• next