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- W4313555845 abstract "Abstract The association between long-term exposure to e-waste and poor health is well established, but how e-waste exposure affects DNA methylation is understudied. In this study, we investigated the concentration of PCBs in environmental samples around the e-waste area and measured the DNA damage levels and the alternation of DNA methylation in peripheral blood mononuclear cells (PBMCs) collected from a population exposed to e-waste. There was serious PCB contamination in the soil, water, and plants around the e-waste recycling area. The concentration of 28 PCB congeners in blood samples of e-waste recycling workers was elevated than those of the reference group. DNA damage levels were significantly higher than that of samples from the reference group by detecting the SCGE, CA, and CBMN assay. Eventually, we found that the methylation level of 1233 gene loci was changed in the exposure group. Bioinformatic analysis of differential genes revealed that the hypermethylated genes were enriched in cell component movement and regulation of cell function, and hypomethylated genes were involved in the cellular metabolic process. Among the 30 genes we tested, 14 genes showed a negative correlation between methylation level and expression level. Therefore, e-waste exposure potentially increased levels of DNA damage and alters DNA methylation, which would likely impact human health." @default.
- W4313555845 created "2023-01-06" @default.
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- W4313555845 date "2023-01-05" @default.
- W4313555845 modified "2023-10-17" @default.
- W4313555845 title "Influence of e-waste exposure on DNA damage and DNA methylation in people living near recycling sites" @default.
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- W4313555845 doi "https://doi.org/10.21203/rs.3.rs-2283897/v1" @default.
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