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- W4313556627 endingPage "e12829" @default.
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- W4313556627 abstract "Curcumin, from the rhizome of turmeric (Curcuma longa L.), has a wide variety of biological activities. Unfortunately, its poor water-solubility greatly limits its bioavailability. The purpose of this study was to evaluate CUMINUP60®, a novel preparation utilizing a solvent-free, co-grinding method designed to improve curcumin’s bioavailability. We performed a single-center crossover experiment to compare the new product with standard 95% curcumin in the blood plasma of twelve healthy adults (10 males, 2 females). Total bioavailability of curcumin and its sulfate and glucuronide conjugates from the test product, measured by their areas under the curve over 12 h (AUC0-T), showed a combined increase of 178-fold over standard curcumin and its conjugates from the reference product. The new product represents a significant improvement for providing greater bioavailability of curcumin, as compared with several other branded preparations. It therefore has broad applications for preparing curcumin as a more effective health ingredient in functional foods, beverages, and nutraceuticals." @default.
- W4313556627 created "2023-01-06" @default.
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- W4313556627 date "2023-01-01" @default.
- W4313556627 modified "2023-09-26" @default.
- W4313556627 title "A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study" @default.
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- W4313556627 doi "https://doi.org/10.1016/j.heliyon.2023.e12829" @default.
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- W4313556627 hasPublicationYear "2023" @default.
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