Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313558864> ?p ?o ?g. }
- W4313558864 abstract "Ovarian cancer (OV) is the most lethal form of gynecological malignancy worldwide, with limited therapeutic options and high recurrence rates. However, research focusing on prognostic patterns of ferroptosis-related genes (FRGs) in ovarian cancer is still lacking. From the 6,406 differentially expressed genes (DEGs) between TCGA-OV (n = 376) and GTEx cohort (n = 180), we identified 63 potential ferroptosis-related genes. Through the LASSO-penalized Cox analysis, 3 prognostic genes, SLC7A11, ZFP36, and TTBK2, were finally distinguished. The time-dependent ROC curves and K-M survival analysis performed powerful prognostic ability of the 3-gene signature. Stepwise, we constructed and validated the nomogram based on the 3-gene signature and clinical features, with promising prognostic value in both TCGA (p-value < .0001) and ICGC cohort (p-value = .0064). Gene Set Enrichment Analysis elucidated several potential pathways between the groups stratified by 3-gene signature, while the m6A gene analysis implied higher m6A level in the high-risk group. We applied the CIBERSORT algorithm to distinct tumor immune microenvironment between two groups, with less activated dendritic cells (DCs) and plasma cells, more M0 macrophages infiltration, and higher expression of key immune checkpoint molecules (CD274, CTLA4, HAVCR2, and PDCD1LG2) in the high-risk group. In addition, the low-risk group exhibited more favorable immunotherapy and chemotherapy responses. Collectively, our findings provided new prospects in the role of ferroptosis-related genes, as a promising prediction tool for prognosis and immune responses, in order to assist personalized treatment decision-making among ovarian cancer patients." @default.
- W4313558864 created "2023-01-06" @default.
- W4313558864 creator A5009318195 @default.
- W4313558864 creator A5010776860 @default.
- W4313558864 creator A5052702561 @default.
- W4313558864 creator A5055838753 @default.
- W4313558864 creator A5061102034 @default.
- W4313558864 creator A5079594267 @default.
- W4313558864 creator A5090063533 @default.
- W4313558864 date "2023-01-05" @default.
- W4313558864 modified "2023-10-11" @default.
- W4313558864 title "Construction and validation of a novel ferroptosis-related signature for evaluating prognosis and immune microenvironment in ovarian cancer" @default.
- W4313558864 cites W1011684177 @default.
- W4313558864 cites W1985987855 @default.
- W4313558864 cites W2045868505 @default.
- W4313558864 cites W2091931130 @default.
- W4313558864 cites W2106391842 @default.
- W4313558864 cites W2123696077 @default.
- W4313558864 cites W2133464976 @default.
- W4313558864 cites W2134576998 @default.
- W4313558864 cites W2214802907 @default.
- W4313558864 cites W2217355440 @default.
- W4313558864 cites W2234923158 @default.
- W4313558864 cites W2280016334 @default.
- W4313558864 cites W2529607059 @default.
- W4313558864 cites W2561499686 @default.
- W4313558864 cites W2790898945 @default.
- W4313558864 cites W2886498337 @default.
- W4313558864 cites W2889646458 @default.
- W4313558864 cites W2928665623 @default.
- W4313558864 cites W2939322913 @default.
- W4313558864 cites W2939543377 @default.
- W4313558864 cites W2943584912 @default.
- W4313558864 cites W2943793201 @default.
- W4313558864 cites W2945357020 @default.
- W4313558864 cites W2946217053 @default.
- W4313558864 cites W2950891099 @default.
- W4313558864 cites W2965406966 @default.
- W4313558864 cites W2972917142 @default.
- W4313558864 cites W2975105312 @default.
- W4313558864 cites W2979937337 @default.
- W4313558864 cites W2981179816 @default.
- W4313558864 cites W2990647996 @default.
- W4313558864 cites W3010943409 @default.
- W4313558864 cites W3019038073 @default.
- W4313558864 cites W3036375967 @default.
- W4313558864 cites W3092122627 @default.
- W4313558864 cites W3106235644 @default.
- W4313558864 cites W3108960632 @default.
- W4313558864 cites W3118255995 @default.
- W4313558864 cites W3119376173 @default.
- W4313558864 cites W3134087839 @default.
- W4313558864 cites W3134427986 @default.
- W4313558864 cites W3158754692 @default.
- W4313558864 cites W3165230273 @default.
- W4313558864 cites W3186649896 @default.
- W4313558864 cites W4205308127 @default.
- W4313558864 cites W4206841660 @default.
- W4313558864 cites W4210867925 @default.
- W4313558864 cites W4223949718 @default.
- W4313558864 cites W4288069643 @default.
- W4313558864 doi "https://doi.org/10.3389/fgene.2022.1094474" @default.
- W4313558864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685851" @default.
- W4313558864 hasPublicationYear "2023" @default.
- W4313558864 type Work @default.
- W4313558864 citedByCount "2" @default.
- W4313558864 countsByYear W43135588642023 @default.
- W4313558864 crossrefType "journal-article" @default.
- W4313558864 hasAuthorship W4313558864A5009318195 @default.
- W4313558864 hasAuthorship W4313558864A5010776860 @default.
- W4313558864 hasAuthorship W4313558864A5052702561 @default.
- W4313558864 hasAuthorship W4313558864A5055838753 @default.
- W4313558864 hasAuthorship W4313558864A5061102034 @default.
- W4313558864 hasAuthorship W4313558864A5079594267 @default.
- W4313558864 hasAuthorship W4313558864A5090063533 @default.
- W4313558864 hasBestOaLocation W43135588641 @default.
- W4313558864 hasConcept C104317684 @default.
- W4313558864 hasConcept C121608353 @default.
- W4313558864 hasConcept C143998085 @default.
- W4313558864 hasConcept C150194340 @default.
- W4313558864 hasConcept C162317418 @default.
- W4313558864 hasConcept C203014093 @default.
- W4313558864 hasConcept C2776107976 @default.
- W4313558864 hasConcept C2777701055 @default.
- W4313558864 hasConcept C2779399171 @default.
- W4313558864 hasConcept C2779733811 @default.
- W4313558864 hasConcept C2780427987 @default.
- W4313558864 hasConcept C34626388 @default.
- W4313558864 hasConcept C502942594 @default.
- W4313558864 hasConcept C54355233 @default.
- W4313558864 hasConcept C70721500 @default.
- W4313558864 hasConcept C71924100 @default.
- W4313558864 hasConcept C86803240 @default.
- W4313558864 hasConcept C8891405 @default.
- W4313558864 hasConceptScore W4313558864C104317684 @default.
- W4313558864 hasConceptScore W4313558864C121608353 @default.
- W4313558864 hasConceptScore W4313558864C143998085 @default.
- W4313558864 hasConceptScore W4313558864C150194340 @default.
- W4313558864 hasConceptScore W4313558864C162317418 @default.
- W4313558864 hasConceptScore W4313558864C203014093 @default.