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- W4313558964 abstract "Lophatherum gracile (L. gracile) has long been used as a functional food and herbal medicine. Previous studies have demonstrated that extracts of L. gracile attenuate inflammatory response and inhibit SARS-CoV-2 replication; however, the underlying active constituents have yet to be identified. This study investigated the bioactive components of L. gracile. Flavone C-glycosides of L. gracile were found to dominate both anti-inflammatory and antiviral effects. A simple chromatography-based method was developed to obtain flavone C-glycoside-enriched extract (FlavoLG) from L. gracile. FlavoLG and its major flavone C-glycoside isoorientin were shown to restrict respiratory bursts and the formation of neutrophil extracellular traps in activated human neutrophils. FlavoLG and isoorientin were also shown to inhibit SARS-CoV-2 pseudovirus infection by interfering with the binding of the SARS-CoV-2 spike on ACE2. These results provide scientific evidence indicating the efficacy of L. gracile as a potential supplement for treating neutrophil-associated COVID-19." @default.
- W4313558964 created "2023-01-06" @default.
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- W4313558964 date "2023-02-01" @default.
- W4313558964 modified "2023-10-14" @default.
- W4313558964 title "Anti-inflammatory and antiviral activities of flavone C-glycosides of Lophatherum gracile for COVID-19" @default.
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- W4313558964 doi "https://doi.org/10.1016/j.jff.2023.105407" @default.
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