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• W4313558992 abstract "Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) of a stressor, which defines the perturbation in a biological system (molecular initiating event, MIE), and a dependent series of key events (KEs), ending with an adverse outcome (AO). AOPs have recently become the subject of intense studies in a view to better understand the mechanisms of nanomaterial (NM) toxicity. Silver nanoparticles (Ag NPs) are one of the most explored nanostructures and are extensively used in various application. This, in turn, has increased the potential for interactions of Ag NPs with environments, and toxicity to human health. The aim of this study was to construct a putative AOPs (pAOP) related to reproductive toxicity of Ag NPs, in order to lay the groundwork for a better comprehension of mechanisms affecting both undesired toxicity (against human cell) and expected toxicity (against microorganisms).PubMed and Scopus were systematically searched for peer-reviewed studies examining reproductive toxicity potential of Ag NPs. The quality of selected studies was assessed through ToxRTool. Eventually, forty-eight studies published between 2005 and 2022 were selected to identify the mechanisms of Ag NPs impact on reproductive function in human male. The biological endpoints, measurements, and results were extracted from these studies. Where possible, endpoints were assigned to a potential KE and an AO using expert judgment. Then, KEs were classified at each major level of biological organization.We identified the impairment of intracellular SH-containing biomolecules, which are major cellular antioxidants, as a putative MIE, with subsequent KEs defined as ROS accumulation, mitochondrial damage, DNA damage and lipid peroxidation, apoptosis, reduced production of reproductive hormones and reduced quality of sperm. These successive KEs may result in impaired male fertility (AO).This research recapitulates and schematically represents complex literature data gathered from different biological levels and propose a pAOP related to the reproductive toxicity induced by AgNPs. The development of AOPs specific to NMs should be encouraged in order to provide new insights to gain a better understanding of NP toxicity." @default.
• W4313558992 created "2023-01-06" @default.
• W4313558992 creator A5004004582 @default.
• W4313558992 creator A5013251208 @default.
• W4313558992 creator A5058253553 @default.
• W4313558992 creator A5086999677 @default.
• W4313558992 date "2023-01-05" @default.
• W4313558992 modified "2023-10-17" @default.
• W4313558992 title "Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review" @default.
• W4313558992 cites W1218769666 @default.
• W4313558992 cites W133435692 @default.
• W4313558992 cites W1855207464 @default.
• W4313558992 cites W1958044292 @default.
• W4313558992 cites W1959991859 @default.
• W4313558992 cites W1965724633 @default.
• W4313558992 cites W1970158294 @default.
• W4313558992 cites W1972411412 @default.
• W4313558992 cites W1975121053 @default.
• W4313558992 cites W1976504036 @default.
• W4313558992 cites W1984140215 @default.
• W4313558992 cites W1987386891 @default.
• W4313558992 cites W1989644067 @default.
• W4313558992 cites W1995338662 @default.
• W4313558992 cites W1995618558 @default.
• W4313558992 cites W1996413994 @default.
• W4313558992 cites W2001278454 @default.
• W4313558992 cites W2001629471 @default.
• W4313558992 cites W2002060013 @default.
• W4313558992 cites W2008157182 @default.
• W4313558992 cites W2008472387 @default.
• W4313558992 cites W2009792330 @default.
• W4313558992 cites W2013262011 @default.
• W4313558992 cites W2024144146 @default.
• W4313558992 cites W2025088507 @default.
• W4313558992 cites W2027036579 @default.
• W4313558992 cites W2027502328 @default.
• W4313558992 cites W2031027059 @default.
• W4313558992 cites W2032314622 @default.
• W4313558992 cites W2034761114 @default.
• W4313558992 cites W2036098906 @default.
• W4313558992 cites W2042795875 @default.
• W4313558992 cites W2045095022 @default.
• W4313558992 cites W2049218865 @default.
• W4313558992 cites W2055608422 @default.
• W4313558992 cites W2058457363 @default.
• W4313558992 cites W2058831880 @default.
• W4313558992 cites W2062405692 @default.
• W4313558992 cites W2068025923 @default.
• W4313558992 cites W2072089379 @default.
• W4313558992 cites W2075565367 @default.
• W4313558992 cites W2078078000 @default.
• W4313558992 cites W2078287490 @default.
• W4313558992 cites W2081009582 @default.
• W4313558992 cites W2081934538 @default.
• W4313558992 cites W2082794635 @default.
• W4313558992 cites W2084456160 @default.
• W4313558992 cites W2085241772 @default.
• W4313558992 cites W2086809297 @default.
• W4313558992 cites W2087468617 @default.
• W4313558992 cites W2090929525 @default.
• W4313558992 cites W2091756261 @default.
• W4313558992 cites W2094262202 @default.
• W4313558992 cites W2095097473 @default.
• W4313558992 cites W2101479194 @default.
• W4313558992 cites W2104777847 @default.
• W4313558992 cites W2107061989 @default.
• W4313558992 cites W2111789942 @default.
• W4313558992 cites W2111812837 @default.
• W4313558992 cites W2117278034 @default.
• W4313558992 cites W2119347441 @default.
• W4313558992 cites W2119390239 @default.
• W4313558992 cites W2119682509 @default.
• W4313558992 cites W2126543287 @default.
• W4313558992 cites W2126661658 @default.
• W4313558992 cites W2128478608 @default.
• W4313558992 cites W2131122830 @default.
• W4313558992 cites W2132714700 @default.
• W4313558992 cites W2135736919 @default.
• W4313558992 cites W2137431771 @default.
• W4313558992 cites W2141237239 @default.
• W4313558992 cites W2142470460 @default.
• W4313558992 cites W2146482929 @default.
• W4313558992 cites W2148427274 @default.
• W4313558992 cites W2152005182 @default.
• W4313558992 cites W2156098321 @default.
• W4313558992 cites W2160569420 @default.
• W4313558992 cites W2161788422 @default.
• W4313558992 cites W2161946971 @default.
• W4313558992 cites W2163762391 @default.
• W4313558992 cites W2163769668 @default.
• W4313558992 cites W2169466952 @default.
• W4313558992 cites W2172101363 @default.
• W4313558992 cites W2281868145 @default.
• W4313558992 cites W2316002867 @default.
• W4313558992 cites W2317692628 @default.
• W4313558992 cites W2333223910 @default.
• W4313558992 cites W2337216790 @default.
• W4313558992 cites W246286872 @default.
• W4313558992 cites W2520304360 @default.
• W4313558992 cites W2521880295 @default.

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