FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313559062> ?p ?o ?g. }

• W4313559062 endingPage "77" @default.
• W4313559062 startingPage "77" @default.
• W4313559062 abstract "The GluR3 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) has been identified as a target for autoantibodies (Aabs) in autoimmune encephalopathy and other diseases. Recent studies have proposed mechanisms by which these Aabs act, but their exact role in neuronal excitability is yet to be established. Patient Aabs have been shown to bind to specific regions within the GluR3 subunit. GLUR3B peptides were designed based on described (ELISA) immunogenic epitopes for Aabs and an immunisation strategy was used to generate novel anti-AMPAR Aabs. Target-specific binding and specificity of affinity-purified anti-AMPAR Aabs was confirmed using enzyme-linked immunosorbent assay, immunocytochemistry and Western blot. Functional anti-AMPAR Aab effects were determined on excitatory postsynaptic currents (EPSCs) from primary hippocampal neurons using whole-cell patch-clamp electrophysiology. Acute (10 or 30 min) or longer-term (24 h) application of anti-AMPAR Aabs caused a significant reduction in the mean frequency of spontaneous and miniature EPSCs in hippocampal neurons. Our data demonstrate that anti-AMPAR Aabs targeting peptides linked to auto-immune diseases mediate inhibitory effects on neuronal excitability at the synaptic level, such effects may lead to disruption of the excitatory/inhibitory balance at a network level." @default.
• W4313559062 created "2023-01-06" @default.
• W4313559062 creator A5018085400 @default.
• W4313559062 creator A5027679218 @default.
• W4313559062 creator A5039650196 @default.
• W4313559062 creator A5041519854 @default.
• W4313559062 creator A5054838144 @default.
• W4313559062 creator A5073130854 @default.
• W4313559062 creator A5080342871 @default.
• W4313559062 date "2023-01-04" @default.
• W4313559062 modified "2023-10-18" @default.
• W4313559062 title "Anti-AMPA Receptor Autoantibodies Reduce Excitatory Currents in Rat Hippocampal Neurons" @default.
• W4313559062 cites W1563208041 @default.
• W4313559062 cites W1979266787 @default.
• W4313559062 cites W1982043728 @default.
• W4313559062 cites W1996743365 @default.
• W4313559062 cites W2012412453 @default.
• W4313559062 cites W2012678641 @default.
• W4313559062 cites W2019019017 @default.
• W4313559062 cites W2028943752 @default.
• W4313559062 cites W2030795964 @default.
• W4313559062 cites W2031172241 @default.
• W4313559062 cites W2031264052 @default.
• W4313559062 cites W2036946642 @default.
• W4313559062 cites W2041525670 @default.
• W4313559062 cites W2044997440 @default.
• W4313559062 cites W2061056490 @default.
• W4313559062 cites W2087797354 @default.
• W4313559062 cites W2112882116 @default.
• W4313559062 cites W2112927743 @default.
• W4313559062 cites W2137421560 @default.
• W4313559062 cites W2165804863 @default.
• W4313559062 cites W2169578249 @default.
• W4313559062 cites W2252363813 @default.
• W4313559062 cites W2409215019 @default.
• W4313559062 cites W2566931670 @default.
• W4313559062 cites W2595114075 @default.
• W4313559062 cites W2617402993 @default.
• W4313559062 cites W2738142604 @default.
• W4313559062 cites W2740449411 @default.
• W4313559062 cites W2888669082 @default.
• W4313559062 cites W2988216296 @default.
• W4313559062 cites W3047879827 @default.
• W4313559062 cites W3119454518 @default.
• W4313559062 cites W3177655109 @default.
• W4313559062 cites W3196372177 @default.
• W4313559062 cites W4211135869 @default.
• W4313559062 doi "https://doi.org/10.3390/ph16010077" @default.
• W4313559062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36678574" @default.
• W4313559062 hasPublicationYear "2023" @default.
• W4313559062 type Work @default.
• W4313559062 citedByCount "1" @default.
• W4313559062 crossrefType "journal-article" @default.
• W4313559062 hasAuthorship W4313559062A5018085400 @default.
• W4313559062 hasAuthorship W4313559062A5027679218 @default.
• W4313559062 hasAuthorship W4313559062A5039650196 @default.
• W4313559062 hasAuthorship W4313559062A5041519854 @default.
• W4313559062 hasAuthorship W4313559062A5054838144 @default.
• W4313559062 hasAuthorship W4313559062A5073130854 @default.
• W4313559062 hasAuthorship W4313559062A5080342871 @default.
• W4313559062 hasBestOaLocation W43135590621 @default.
• W4313559062 hasConcept C112592302 @default.
• W4313559062 hasConcept C126322002 @default.
• W4313559062 hasConcept C147944092 @default.
• W4313559062 hasConcept C148762608 @default.
• W4313559062 hasConcept C160268369 @default.
• W4313559062 hasConcept C169760540 @default.
• W4313559062 hasConcept C170493617 @default.
• W4313559062 hasConcept C17077164 @default.
• W4313559062 hasConcept C185263204 @default.
• W4313559062 hasConcept C185592680 @default.
• W4313559062 hasConcept C197341189 @default.
• W4313559062 hasConcept C2780648746 @default.
• W4313559062 hasConcept C61174792 @default.
• W4313559062 hasConcept C71924100 @default.
• W4313559062 hasConcept C86803240 @default.
• W4313559062 hasConceptScore W4313559062C112592302 @default.
• W4313559062 hasConceptScore W4313559062C126322002 @default.
• W4313559062 hasConceptScore W4313559062C147944092 @default.
• W4313559062 hasConceptScore W4313559062C148762608 @default.
• W4313559062 hasConceptScore W4313559062C160268369 @default.
• W4313559062 hasConceptScore W4313559062C169760540 @default.
• W4313559062 hasConceptScore W4313559062C170493617 @default.
• W4313559062 hasConceptScore W4313559062C17077164 @default.
• W4313559062 hasConceptScore W4313559062C185263204 @default.
• W4313559062 hasConceptScore W4313559062C185592680 @default.
• W4313559062 hasConceptScore W4313559062C197341189 @default.
• W4313559062 hasConceptScore W4313559062C2780648746 @default.
• W4313559062 hasConceptScore W4313559062C61174792 @default.
• W4313559062 hasConceptScore W4313559062C71924100 @default.
• W4313559062 hasConceptScore W4313559062C86803240 @default.
• W4313559062 hasIssue "1" @default.
• W4313559062 hasLocation W43135590621 @default.
• W4313559062 hasLocation W43135590622 @default.
• W4313559062 hasLocation W43135590623 @default.
• W4313559062 hasLocation W43135590624 @default.
• W4313559062 hasOpenAccess W4313559062 @default.
• W4313559062 hasPrimaryLocation W43135590621 @default.

• next