Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313559151> ?p ?o ?g. }
- W4313559151 endingPage "187" @default.
- W4313559151 startingPage "187" @default.
- W4313559151 abstract "Antibodies are not only an important class of biotherapeutic drugs, but also are targeting moieties for achieving active targeting drug delivery. Meanwhile, the rapidly increasing application of antibodies and Fc-fusion proteins has inspired the emerging development of downstream processing technologies. Thus, IgG Fc affinity ligands have come into being and have been widely exploited in antibody purification strategies. Given the high binding affinity and specificity to IgGs, binding stability in physiological medium conditions, and favorable toxicity and immunogenicity profiles, Fc affinity ligands are gradually applied to antibody delivery, non-covalent antibody–drug conjugates or antibody-mediated active-targeted drug delivery systems. In this review, we will briefly introduce IgG affinity ligands that are widely used at present and summarize their diverse applications in the field of antibody-involved drug delivery. The challenges and outlook of these systems are also discussed." @default.
- W4313559151 created "2023-01-06" @default.
- W4313559151 creator A5027351945 @default.
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- W4313559151 creator A5056450584 @default.
- W4313559151 creator A5069587361 @default.
- W4313559151 creator A5079412241 @default.
- W4313559151 date "2023-01-05" @default.
- W4313559151 modified "2023-09-27" @default.
- W4313559151 title "IgG Fc Affinity Ligands and Their Applications in Antibody-Involved Drug Delivery: A Brief Review" @default.
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