Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313559179> ?p ?o ?g. }
- W4313559179 endingPage "993" @default.
- W4313559179 startingPage "993" @default.
- W4313559179 abstract "Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disease whose etiology remains unresolved; nonetheless, mutations of superoxide dismutase 1 (SOD1) have been associated with several variants of ALS. Currently available pharmacologic interventions are only symptomatic and palliative in effect; therefore, there is a pressing demand for more effective drugs. This study examined potential therapeutic effects of growth hormone secretagogues (GHSs), a large family of synthetic compounds, as possible candidates for the treatment of ALS. Human neuroblastoma cells expressing the SOD1-G93A mutated protein (SH-SY5Y SOD1G93A cells) were incubated for 24 h with H2O2 (150 µM) in the absence, or presence, of GHS (1 µM), in order to study the protective effect of GHS against increased oxidative stress. The two GHSs examined in this study, hexarelin and JMV2894, protected cells from H2O2-induced cytotoxicity by activating molecules that regulate apoptosis and promote cell survival processes. These findings suggest the possibility of developing new GHS-based anti-oxidant and neuroprotective drugs with improved therapeutic potential. Further investigations are required for the following: (i) to clarify GHS molecular mechanisms of action, and (ii) to envisage the development of new GHSs that may be useful in ALS therapy." @default.
- W4313559179 created "2023-01-06" @default.
- W4313559179 creator A5012769425 @default.
- W4313559179 creator A5017160244 @default.
- W4313559179 creator A5018263722 @default.
- W4313559179 creator A5026741989 @default.
- W4313559179 creator A5031711272 @default.
- W4313559179 creator A5049252544 @default.
- W4313559179 creator A5076609343 @default.
- W4313559179 creator A5076976446 @default.
- W4313559179 creator A5081375351 @default.
- W4313559179 date "2023-01-04" @default.
- W4313559179 modified "2023-10-03" @default.
- W4313559179 title "Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein" @default.
- W4313559179 cites W1668456947 @default.
- W4313559179 cites W1845459216 @default.
- W4313559179 cites W1933803332 @default.
- W4313559179 cites W1965681020 @default.
- W4313559179 cites W1968767714 @default.
- W4313559179 cites W1970390048 @default.
- W4313559179 cites W1975017942 @default.
- W4313559179 cites W1988779395 @default.
- W4313559179 cites W1993781471 @default.
- W4313559179 cites W1996024251 @default.
- W4313559179 cites W2015163544 @default.
- W4313559179 cites W2021247637 @default.
- W4313559179 cites W2040678584 @default.
- W4313559179 cites W2042326514 @default.
- W4313559179 cites W2044387885 @default.
- W4313559179 cites W2052018772 @default.
- W4313559179 cites W2052805063 @default.
- W4313559179 cites W2056540017 @default.
- W4313559179 cites W2069108649 @default.
- W4313559179 cites W2076359142 @default.
- W4313559179 cites W2081700231 @default.
- W4313559179 cites W2085143181 @default.
- W4313559179 cites W2089800528 @default.
- W4313559179 cites W2090205374 @default.
- W4313559179 cites W2104109524 @default.
- W4313559179 cites W2111934536 @default.
- W4313559179 cites W2123851034 @default.
- W4313559179 cites W2139597470 @default.
- W4313559179 cites W2146596365 @default.
- W4313559179 cites W2147622563 @default.
- W4313559179 cites W2152165298 @default.
- W4313559179 cites W2154581555 @default.
- W4313559179 cites W2160099189 @default.
- W4313559179 cites W2175296021 @default.
- W4313559179 cites W2195247023 @default.
- W4313559179 cites W2558567565 @default.
- W4313559179 cites W2568510753 @default.
- W4313559179 cites W2594925179 @default.
- W4313559179 cites W2612410326 @default.
- W4313559179 cites W2725805506 @default.
- W4313559179 cites W2742827847 @default.
- W4313559179 cites W2761242880 @default.
- W4313559179 cites W2761629122 @default.
- W4313559179 cites W2792470718 @default.
- W4313559179 cites W2891369976 @default.
- W4313559179 cites W2965860432 @default.
- W4313559179 cites W2971106694 @default.
- W4313559179 cites W2971699381 @default.
- W4313559179 cites W3005132674 @default.
- W4313559179 cites W3005286987 @default.
- W4313559179 cites W3006510973 @default.
- W4313559179 cites W3029492181 @default.
- W4313559179 cites W3138815959 @default.
- W4313559179 cites W3162008887 @default.
- W4313559179 cites W3164735937 @default.
- W4313559179 cites W3174251646 @default.
- W4313559179 cites W3197508563 @default.
- W4313559179 cites W3215818202 @default.
- W4313559179 cites W3217583879 @default.
- W4313559179 cites W4200012043 @default.
- W4313559179 cites W4211061743 @default.
- W4313559179 cites W4236884331 @default.
- W4313559179 cites W4296026214 @default.
- W4313559179 doi "https://doi.org/10.3390/ijms24020993" @default.
- W4313559179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36674509" @default.
- W4313559179 hasPublicationYear "2023" @default.
- W4313559179 type Work @default.
- W4313559179 citedByCount "1" @default.
- W4313559179 countsByYear W43135591792023 @default.
- W4313559179 crossrefType "journal-article" @default.
- W4313559179 hasAuthorship W4313559179A5012769425 @default.
- W4313559179 hasAuthorship W4313559179A5017160244 @default.
- W4313559179 hasAuthorship W4313559179A5018263722 @default.
- W4313559179 hasAuthorship W4313559179A5026741989 @default.
- W4313559179 hasAuthorship W4313559179A5031711272 @default.
- W4313559179 hasAuthorship W4313559179A5049252544 @default.
- W4313559179 hasAuthorship W4313559179A5076609343 @default.
- W4313559179 hasAuthorship W4313559179A5076976446 @default.
- W4313559179 hasAuthorship W4313559179A5081375351 @default.
- W4313559179 hasBestOaLocation W43135591791 @default.
- W4313559179 hasConcept C126322002 @default.
- W4313559179 hasConcept C185592680 @default.
- W4313559179 hasConcept C190283241 @default.
- W4313559179 hasConcept C25498285 @default.