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- W4313561271 abstract "RIPK3-ZBP1-MLKL-mediated necroptosis is a proinflammatory cell death process that is crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are prerequisites for executing necroptosis, yet the underlying mechanism of virus-induced RIPK3 activation remains elusive. Interferon-inducible 2'-5' oligoadenylate synthetase-like (OASL) protein is devoid of enzymatic function but displays potent antiviral activity. Here we describe a role of OASL as a virus-induced necroptosis promoter that scaffolds the RIPK3-ZBP1 non-canonical necrosome via liquid-like phase condensation. This liquid-like platform of OASL recruits RIPK3 and ZBP1 via protein-protein interactions to provide spatial segregation for RIPK3 nucleation. This process facilitates the amyloid-like fibril formation and activation of RIPK3 and thereby MLKL phosphorylation for necroptosis. Mice deficient in Oasl1 exhibit severely impaired necroptosis and attenuated inflammation after viral infection, resulting in uncontrolled viral dissemination and lethality. Our study demonstrates an interferon-induced innate response whereby OASL scaffolds RIPK3-ZBP1 assembly via its phase-separated liquid droplets to facilitate necroptosis-mediated antiviral immunity." @default.
- W4313561271 created "2023-01-06" @default.
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- W4313561271 date "2023-01-01" @default.
- W4313561271 modified "2023-10-09" @default.
- W4313561271 title "OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis" @default.
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- W4313561271 cites W1952608303 @default.
- W4313561271 cites W1965286266 @default.
- W4313561271 cites W1966977448 @default.
- W4313561271 cites W1972410570 @default.
- W4313561271 cites W1978527132 @default.
- W4313561271 cites W1979032223 @default.
- W4313561271 cites W1985411011 @default.
- W4313561271 cites W1987186266 @default.
- W4313561271 cites W1993613360 @default.
- W4313561271 cites W1998983498 @default.
- W4313561271 cites W2009958847 @default.
- W4313561271 cites W2015321393 @default.
- W4313561271 cites W2023122823 @default.
- W4313561271 cites W2034006241 @default.
- W4313561271 cites W2035509260 @default.
- W4313561271 cites W2038401000 @default.
- W4313561271 cites W2049476357 @default.
- W4313561271 cites W2052605153 @default.
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- W4313561271 cites W2057880516 @default.
- W4313561271 cites W2058277625 @default.
- W4313561271 cites W2060204808 @default.
- W4313561271 cites W2071769633 @default.
- W4313561271 cites W2076658768 @default.
- W4313561271 cites W2077317536 @default.
- W4313561271 cites W2078819049 @default.
- W4313561271 cites W2084414744 @default.
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- W4313561271 cites W2122550126 @default.
- W4313561271 cites W2132161879 @default.
- W4313561271 cites W2142153502 @default.
- W4313561271 cites W2150860983 @default.
- W4313561271 cites W2403526287 @default.
- W4313561271 cites W2429745182 @default.
- W4313561271 cites W2507605260 @default.
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- W4313561271 cites W2802914881 @default.
- W4313561271 cites W2854081253 @default.
- W4313561271 cites W2883756825 @default.
- W4313561271 cites W2884494766 @default.
- W4313561271 cites W2886143754 @default.
- W4313561271 cites W2902231393 @default.
- W4313561271 cites W2909530938 @default.
- W4313561271 cites W2914907359 @default.
- W4313561271 cites W2969279439 @default.
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- W4313561271 doi "https://doi.org/10.1038/s41556-022-01039-y" @default.
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