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• W4313561276 abstract "Abstract The occurrence of suicidal behaviors increases during adolescence. Hypersensitivity to negative social signals and deficits in cognitive control are putative mechanisms of suicidal behaviors, which necessitate confirmation in youths. Multidomain functional neuroimaging could enhance the identification of patients at suicidal risk beyond standard clinical measures. Three groups of adolescents (N = 96; 78% females, age = 11.6–18.1) were included: patients with depressive disorders and previous suicide attempts (SA, n = 29); patient controls with depressive disorders but without suicide attempt (PC, n = 35); and healthy controls (HC, n = 32). We scanned participants with 3T-MRI during social inclusion/exclusion (Cyberball Game) and response inhibition (Go-NoGo) tasks. Neural activation was indexed by the blood-oxygenation-level dependent (BOLD) of the hemodynamic response during three conditions in the Cyberball Game (“Control condition”, “Social Inclusion”, and “Social Exclusion”), and two conditions in Go-NoGo task (“Go” and “NoGo” blocks). ANCOVA-style analysis identified group effects across three whole-brain contrasts: 1) NoGo vs. Go, 2) Social inclusion vs. control condition, 3) Social inclusion vs. control condition). Normalized contrasts in significant clusters were used to train a support vector machine-based classifier with a stratified 5-fold cross-validation, and diagnostic performance was assessed. In line with previous adult studies, we found that SA had lower activation in the left insula during social inclusion vs. control condition compared to PC and HC. We also found that SA compared to PC had higher activity in the right middle prefrontal gyrus during social exclusion vs. control condition, and in bilateral precentral gyri during NoGo vs. Go conditions. Task-related measures (Self-reported emotional reactivity in the Cyberball Game, response times and number of errors in the Go-NoGo Task) did not discriminate between groups. Moreover, while clinical data (Self-reported depression and impulsivity scores) yielded moderate accuracy (Accuracy: 70%/ Area Under Curve: 0.81), activity during Go-NoGo (81%/0.90), Cyberball Game (89%/0.90), or a combination (88%/0.95) significantly enhanced identification of past suicidal behaviors. In conclusion, adolescent suicidal behaviors are likely associated with neural alterations across multiple domains. Alterations in the processing of social perception and response inhibition may underlie the development of suicidal crises, from onset with social triggers to susceptibility to act out. Neuroimaging should be further tested as a tool to predict suicidal behavior." @default.
• W4313561276 created "2023-01-06" @default.
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• W4313561276 date "2023-01-05" @default.
• W4313561276 modified "2023-10-16" @default.
• W4313561276 title "Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multimodal task-based fMRI study" @default.
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• W4313561276 doi "https://doi.org/10.21203/rs.3.rs-2271723/v1" @default.
• W4313561276 hasPublicationYear "2023" @default.
• W4313561276 type Work @default.

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