FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313561298> ?p ?o ?g. }

• W4313561298 abstract "Animal and human studies suggest the gut microbiome is linked to diabetes but additional data are needed on the associations of the gut microbiome to specific diabetes characteristics. The aim of this study was to examine the associations of gut microbiome composition to insulin resistance [Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)], duration of diabetes, and 4 stages of diabetes [normoglycemia, pre-diabetes, and diabetes with (+) and without (-) medication for diabetes].Data are from a sub-sample (n = 605) of Black and White participants from the 30-year follow-up exam of the prospectively followed community-based Coronary Artery Risk Development in Young Adults cohort (2015-2016; aged 48-60 years). Stool samples were collected and sequenced using the 16S ribosomal RNA method. Microbial measures included: α diversity (within-person), β diversity (between-person), and taxonomies. All analyses were adjusted for demographic, clinical, lifestyle factors, and use of relevant medications (full adjustment). Multivariate linear regression models were used to assess the association of diabetes characteristics with α diversity and genera abundance, while the association with β diversity was analyzed using permutational multivariate analysis of variance. Statistical significance was set to p-value < 0.05 for α and β diversity analyses and to q-value < 0.1 for genera abundance analyses.There were 16.7% of participants with pre-diabetes, and 14.4% with diabetes (9% diabetes+) with median (interquartile range) diabetes duration of 5 (5-10) years. In the fully adjusted models, compared to those with no diabetes, longer diabetes duration and the diabetes + group had a lower α diversity. There were significant differences in β diversity across diabetes-related characteristics. A significantly reduced abundance of butyrate-producing genera was associated with higher HOMA-IR (ex., Anaerostipes and Lachnospiraceae_UCG.004), longer diabetes duration (ex., Agathobacter and Ruminococcus), and diabetes + (ex., Faecalibacterium and Romboutsia).Our results suggest that an adverse alteration of gut microbiome composition is related to higher insulin resistance, longer diabetes duration, and is present in those persons with diabetes using medications. These diabetes-related characteristics were also associated with lower levels of certain butyrate-producing bacteria that produce health-promoting short-chain fatty acids. Understanding the role of gut microbiota in glucose regulation may provide new strategies to reduce the burden of diabetes." @default.
• W4313561298 created "2023-01-06" @default.
• W4313561298 creator A5012285927 @default.
• W4313561298 creator A5018596706 @default.
• W4313561298 creator A5018722034 @default.
• W4313561298 creator A5030750984 @default.
• W4313561298 creator A5033178523 @default.
• W4313561298 creator A5039309278 @default.
• W4313561298 creator A5041494330 @default.
• W4313561298 creator A5058511529 @default.
• W4313561298 creator A5069988352 @default.
• W4313561298 creator A5086915163 @default.
• W4313561298 date "2023-01-05" @default.
• W4313561298 modified "2023-09-25" @default.
• W4313561298 title "Gut microbiome and stages of diabetes in middle-aged adults: CARDIA microbiome study" @default.
• W4313561298 cites W1966921473 @default.
• W4313561298 cites W1975271432 @default.
• W4313561298 cites W1991737476 @default.
• W4313561298 cites W2004549986 @default.
• W4313561298 cites W2020210290 @default.
• W4313561298 cites W2027946048 @default.
• W4313561298 cites W2034285706 @default.
• W4313561298 cites W2055774080 @default.
• W4313561298 cites W2056295623 @default.
• W4313561298 cites W2061219514 @default.
• W4313561298 cites W2063158722 @default.
• W4313561298 cites W2071841602 @default.
• W4313561298 cites W2074036006 @default.
• W4313561298 cites W2074949233 @default.
• W4313561298 cites W2101209169 @default.
• W4313561298 cites W2111644178 @default.
• W4313561298 cites W2153700877 @default.
• W4313561298 cites W2160234571 @default.
• W4313561298 cites W2188930066 @default.
• W4313561298 cites W2606953164 @default.
• W4313561298 cites W2607031541 @default.
• W4313561298 cites W2782658100 @default.
• W4313561298 cites W2808457437 @default.
• W4313561298 cites W2900352306 @default.
• W4313561298 cites W2923028972 @default.
• W4313561298 cites W2945947930 @default.
• W4313561298 cites W2947422914 @default.
• W4313561298 cites W2981160806 @default.
• W4313561298 cites W2998420978 @default.
• W4313561298 cites W3000095198 @default.
• W4313561298 cites W3012071280 @default.
• W4313561298 cites W3016889019 @default.
• W4313561298 cites W3041248404 @default.
• W4313561298 cites W3172756128 @default.
• W4313561298 cites W3183631533 @default.
• W4313561298 cites W3189204301 @default.
• W4313561298 cites W4238714725 @default.
• W4313561298 doi "https://doi.org/10.1186/s12986-022-00721-0" @default.
• W4313561298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36604708" @default.
• W4313561298 hasPublicationYear "2023" @default.
• W4313561298 type Work @default.
• W4313561298 citedByCount "3" @default.
• W4313561298 countsByYear W43135612982018 @default.
• W4313561298 countsByYear W43135612982023 @default.
• W4313561298 crossrefType "journal-article" @default.
• W4313561298 hasAuthorship W4313561298A5012285927 @default.
• W4313561298 hasAuthorship W4313561298A5018596706 @default.
• W4313561298 hasAuthorship W4313561298A5018722034 @default.
• W4313561298 hasAuthorship W4313561298A5030750984 @default.
• W4313561298 hasAuthorship W4313561298A5033178523 @default.
• W4313561298 hasAuthorship W4313561298A5039309278 @default.
• W4313561298 hasAuthorship W4313561298A5041494330 @default.
• W4313561298 hasAuthorship W4313561298A5058511529 @default.
• W4313561298 hasAuthorship W4313561298A5069988352 @default.
• W4313561298 hasAuthorship W4313561298A5086915163 @default.
• W4313561298 hasBestOaLocation W43135612981 @default.
• W4313561298 hasConcept C119060515 @default.
• W4313561298 hasConcept C126322002 @default.
• W4313561298 hasConcept C134018914 @default.
• W4313561298 hasConcept C143121216 @default.
• W4313561298 hasConcept C2777180221 @default.
• W4313561298 hasConcept C2777391703 @default.
• W4313561298 hasConcept C555293320 @default.
• W4313561298 hasConcept C60644358 @default.
• W4313561298 hasConcept C71924100 @default.
• W4313561298 hasConcept C86803240 @default.
• W4313561298 hasConceptScore W4313561298C119060515 @default.
• W4313561298 hasConceptScore W4313561298C126322002 @default.
• W4313561298 hasConceptScore W4313561298C134018914 @default.
• W4313561298 hasConceptScore W4313561298C143121216 @default.
• W4313561298 hasConceptScore W4313561298C2777180221 @default.
• W4313561298 hasConceptScore W4313561298C2777391703 @default.
• W4313561298 hasConceptScore W4313561298C555293320 @default.
• W4313561298 hasConceptScore W4313561298C60644358 @default.
• W4313561298 hasConceptScore W4313561298C71924100 @default.
• W4313561298 hasConceptScore W4313561298C86803240 @default.
• W4313561298 hasFunder F4320332161 @default.
• W4313561298 hasIssue "1" @default.
• W4313561298 hasLocation W43135612981 @default.
• W4313561298 hasLocation W43135612982 @default.
• W4313561298 hasLocation W43135612983 @default.
• W4313561298 hasOpenAccess W4313561298 @default.
• W4313561298 hasPrimaryLocation W43135612981 @default.
• W4313561298 hasRelatedWork W1563850031 @default.
• W4313561298 hasRelatedWork W2061253854 @default.

• next