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- W4313561513 abstract "Abstract Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects including cytokine release syndrome and neurotoxicity. Gene depletion of GM-CSF in CAR-T cells was found preventive against adverse effects, but additional transfections were required to produce CAR-T cells. In this study, we interrupted GM-CSF expression in CAR-T cells by inserting the GM-CSF shRNA-expression cassette in the CAR vector. Reduction of GM-CSF in CAR-T cells could decrease the level of several proinflammatory cytokines without hampering the killing capacity. The manufacture of GM-CSF knockdown CAR-T cells does not require complicated transfections, which makes it more practical and feasible for clinical application." @default.
- W4313561513 created "2023-01-06" @default.
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- W4313561513 date "2023-01-05" @default.
- W4313561513 modified "2023-10-18" @default.
- W4313561513 title "RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines" @default.
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- W4313561513 doi "https://doi.org/10.21203/rs.3.rs-2429383/v1" @default.
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