FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313561581> ?p ?o ?g. }

• W4313561581 abstract "Abstract Triple negative breast cancer (TNBC) is a most aggressive type of breast cancer without effective therapies. Cyclodextrin, a cyclic oligosaccharide is used as drug delivery carrier with cholesterol lowering property. However, whether cyclodextrin can inhibit the proliferation and migration of TNBC as well as the underlying mechanisms are unclear. In the present study, we demonstrated that 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) inhibited the growth and metastasis of TNBC both in vitro and in vivo . Meanwhile, the antitumor effects of HP-β-CD were also observed in a mouse melanoma model. Mechanistically, we initially determined that cholesterol supplementation can attenuate HP-b-CD-inhibited TNBC growth and metastasis both in vitro and in vivo . In vivo , HP-β-CD promoted the infiltration of T cells into the tumor microenvironment (TME) and improved exhaustion of CD8 + T cells via reducing endoplasmic reticulum (ER) stress and immune checkpoint molecules. Additionally, HP-β-CD inhibited the recruitment of tumor associated macrophages to the TME via reducing CCL2-p38MAPK-NF-kB axis. HP-β-CD also inhibited the epithelial mesenchymal transition (EMT) of TNBC cells mediated by transforming growth factor-b (TGF-b) signaling pathway. In summary, the data in the current study suggest that HP-β-CD effectively inhibited proliferation and metastasis of TNBC and melanoma, highlighting HP-β-CD may be a potential general antitumor clinical drug." @default.
• W4313561581 created "2023-01-06" @default.
• W4313561581 creator A5002744113 @default.
• W4313561581 creator A5002891743 @default.
• W4313561581 creator A5005205790 @default.
• W4313561581 creator A5007205089 @default.
• W4313561581 creator A5028875731 @default.
• W4313561581 creator A5031178029 @default.
• W4313561581 creator A5036478960 @default.
• W4313561581 creator A5046898991 @default.
• W4313561581 creator A5052588320 @default.
• W4313561581 creator A5064844254 @default.
• W4313561581 date "2023-01-05" @default.
• W4313561581 modified "2023-09-26" @default.
• W4313561581 title "Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunity" @default.
• W4313561581 cites W1961768905 @default.
• W4313561581 cites W1966095387 @default.
• W4313561581 cites W2001015862 @default.
• W4313561581 cites W2023348062 @default.
• W4313561581 cites W2025850821 @default.
• W4313561581 cites W2033296706 @default.
• W4313561581 cites W2037078880 @default.
• W4313561581 cites W2096027508 @default.
• W4313561581 cites W2118605519 @default.
• W4313561581 cites W2119549339 @default.
• W4313561581 cites W2123528875 @default.
• W4313561581 cites W2136998170 @default.
• W4313561581 cites W2138929540 @default.
• W4313561581 cites W2149914697 @default.
• W4313561581 cites W2359219670 @default.
• W4313561581 cites W2555771555 @default.
• W4313561581 cites W2796494566 @default.
• W4313561581 cites W2803503605 @default.
• W4313561581 cites W2884050374 @default.
• W4313561581 cites W2895926103 @default.
• W4313561581 cites W2896305851 @default.
• W4313561581 cites W2904875558 @default.
• W4313561581 cites W2941036215 @default.
• W4313561581 cites W2955172440 @default.
• W4313561581 cites W3003289748 @default.
• W4313561581 cites W3004336560 @default.
• W4313561581 cites W3045080797 @default.
• W4313561581 cites W3045450469 @default.
• W4313561581 cites W3046751515 @default.
• W4313561581 cites W3094416881 @default.
• W4313561581 cites W3134959125 @default.
• W4313561581 cites W3164212230 @default.
• W4313561581 cites W3171264437 @default.
• W4313561581 cites W4296816736 @default.
• W4313561581 cites W4306649977 @default.
• W4313561581 cites W80971072 @default.
• W4313561581 doi "https://doi.org/10.21203/rs.3.rs-2392210/v1" @default.
• W4313561581 hasPublicationYear "2023" @default.
• W4313561581 type Work @default.
• W4313561581 citedByCount "0" @default.
• W4313561581 crossrefType "posted-content" @default.
• W4313561581 hasAuthorship W4313561581A5002744113 @default.
• W4313561581 hasAuthorship W4313561581A5002891743 @default.
• W4313561581 hasAuthorship W4313561581A5005205790 @default.
• W4313561581 hasAuthorship W4313561581A5007205089 @default.
• W4313561581 hasAuthorship W4313561581A5028875731 @default.
• W4313561581 hasAuthorship W4313561581A5031178029 @default.
• W4313561581 hasAuthorship W4313561581A5036478960 @default.
• W4313561581 hasAuthorship W4313561581A5046898991 @default.
• W4313561581 hasAuthorship W4313561581A5052588320 @default.
• W4313561581 hasAuthorship W4313561581A5064844254 @default.
• W4313561581 hasBestOaLocation W43135615811 @default.
• W4313561581 hasConcept C121608353 @default.
• W4313561581 hasConcept C126322002 @default.
• W4313561581 hasConcept C150903083 @default.
• W4313561581 hasConcept C185592680 @default.
• W4313561581 hasConcept C203014093 @default.
• W4313561581 hasConcept C207001950 @default.
• W4313561581 hasConcept C2776107976 @default.
• W4313561581 hasConcept C2779013556 @default.
• W4313561581 hasConcept C2780110267 @default.
• W4313561581 hasConcept C3020616263 @default.
• W4313561581 hasConcept C502942594 @default.
• W4313561581 hasConcept C530470458 @default.
• W4313561581 hasConcept C71924100 @default.
• W4313561581 hasConcept C76419328 @default.
• W4313561581 hasConcept C86803240 @default.
• W4313561581 hasConcept C8891405 @default.
• W4313561581 hasConceptScore W4313561581C121608353 @default.
• W4313561581 hasConceptScore W4313561581C126322002 @default.
• W4313561581 hasConceptScore W4313561581C150903083 @default.
• W4313561581 hasConceptScore W4313561581C185592680 @default.
• W4313561581 hasConceptScore W4313561581C203014093 @default.
• W4313561581 hasConceptScore W4313561581C207001950 @default.
• W4313561581 hasConceptScore W4313561581C2776107976 @default.
• W4313561581 hasConceptScore W4313561581C2779013556 @default.
• W4313561581 hasConceptScore W4313561581C2780110267 @default.
• W4313561581 hasConceptScore W4313561581C3020616263 @default.
• W4313561581 hasConceptScore W4313561581C502942594 @default.
• W4313561581 hasConceptScore W4313561581C530470458 @default.
• W4313561581 hasConceptScore W4313561581C71924100 @default.
• W4313561581 hasConceptScore W4313561581C76419328 @default.
• W4313561581 hasConceptScore W4313561581C86803240 @default.
• W4313561581 hasConceptScore W4313561581C8891405 @default.
• W4313561581 hasLocation W43135615811 @default.

• next