Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313561610> ?p ?o ?g. }
- W4313561610 endingPage "308" @default.
- W4313561610 startingPage "295" @default.
- W4313561610 abstract "Abstract It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane pore-forming molecule that has been shown to execute pyroptotic cell death and thus to serve as a potential cancer checkpoint. In the present study, we show that human T cells express GSDME and, surprisingly, that this expression is associated with durable viability and repurposed for the release of the alarmin interleukin (IL)-1α. This property was restricted to a subset of human helper type 17 T cells with specificity for Candida albicans and regulated by a T cell-intrinsic NLRP3 inflammasome, and its engagement of a proteolytic cascade of successive caspase-8, caspase-3 and GSDME cleavage after T cell receptor stimulation and calcium-licensed calpain maturation of the pro-IL-1α form. Our results indicate that GSDME pore formation in T cells is a mechanism of unconventional cytokine release. This finding diversifies our understanding of the functional repertoire and mechanistic equipment of T cells and has implications for antifungal immunity." @default.
- W4313561610 created "2023-01-06" @default.
- W4313561610 creator A5006091846 @default.
- W4313561610 creator A5006344666 @default.
- W4313561610 creator A5009266687 @default.
- W4313561610 creator A5020507966 @default.
- W4313561610 creator A5025197980 @default.
- W4313561610 creator A5031606054 @default.
- W4313561610 creator A5034120381 @default.
- W4313561610 creator A5037927181 @default.
- W4313561610 creator A5039660156 @default.
- W4313561610 creator A5050352383 @default.
- W4313561610 creator A5050413394 @default.
- W4313561610 creator A5053221129 @default.
- W4313561610 creator A5053257775 @default.
- W4313561610 creator A5062221037 @default.
- W4313561610 creator A5066175032 @default.
- W4313561610 creator A5074989047 @default.
- W4313561610 creator A5083436454 @default.
- W4313561610 creator A5083894549 @default.
- W4313561610 creator A5087283331 @default.
- W4313561610 creator A5091410216 @default.
- W4313561610 date "2023-01-05" @default.
- W4313561610 modified "2023-10-10" @default.
- W4313561610 title "Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation" @default.
- W4313561610 cites W1571384054 @default.
- W4313561610 cites W1588614670 @default.
- W4313561610 cites W1594893804 @default.
- W4313561610 cites W1813258042 @default.
- W4313561610 cites W1864325817 @default.
- W4313561610 cites W1928540112 @default.
- W4313561610 cites W1971915082 @default.
- W4313561610 cites W1987329700 @default.
- W4313561610 cites W1988043250 @default.
- W4313561610 cites W1995194119 @default.
- W4313561610 cites W2012680181 @default.
- W4313561610 cites W2015347941 @default.
- W4313561610 cites W2033945320 @default.
- W4313561610 cites W2034453891 @default.
- W4313561610 cites W2036012609 @default.
- W4313561610 cites W2043897997 @default.
- W4313561610 cites W2063781137 @default.
- W4313561610 cites W2065330071 @default.
- W4313561610 cites W2076063079 @default.
- W4313561610 cites W2090147735 @default.
- W4313561610 cites W2091145069 @default.
- W4313561610 cites W2112837750 @default.
- W4313561610 cites W2116634113 @default.
- W4313561610 cites W2123093300 @default.
- W4313561610 cites W2142017607 @default.
- W4313561610 cites W2144288685 @default.
- W4313561610 cites W2146512944 @default.
- W4313561610 cites W2179438025 @default.
- W4313561610 cites W2182226868 @default.
- W4313561610 cites W2305577863 @default.
- W4313561610 cites W2328548852 @default.
- W4313561610 cites W2346799309 @default.
- W4313561610 cites W2420118023 @default.
- W4313561610 cites W2439698816 @default.
- W4313561610 cites W2462773201 @default.
- W4313561610 cites W2468316178 @default.
- W4313561610 cites W2608687752 @default.
- W4313561610 cites W2616875005 @default.
- W4313561610 cites W2778820157 @default.
- W4313561610 cites W2780834529 @default.
- W4313561610 cites W2885770511 @default.
- W4313561610 cites W2890228312 @default.
- W4313561610 cites W2898598946 @default.
- W4313561610 cites W2900968222 @default.
- W4313561610 cites W2906713427 @default.
- W4313561610 cites W2919260269 @default.
- W4313561610 cites W2983652778 @default.
- W4313561610 cites W2984573112 @default.
- W4313561610 cites W3001655988 @default.
- W4313561610 cites W3011500848 @default.
- W4313561610 cites W3029533837 @default.
- W4313561610 cites W3122547302 @default.
- W4313561610 cites W3152675680 @default.
- W4313561610 cites W4205247356 @default.
- W4313561610 cites W4210362116 @default.
- W4313561610 cites W4220831425 @default.
- W4313561610 doi "https://doi.org/10.1038/s41590-022-01386-w" @default.
- W4313561610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36604548" @default.
- W4313561610 hasPublicationYear "2023" @default.
- W4313561610 type Work @default.
- W4313561610 citedByCount "13" @default.
- W4313561610 countsByYear W43135616102023 @default.
- W4313561610 crossrefType "journal-article" @default.
- W4313561610 hasAuthorship W4313561610A5006091846 @default.
- W4313561610 hasAuthorship W4313561610A5006344666 @default.
- W4313561610 hasAuthorship W4313561610A5009266687 @default.
- W4313561610 hasAuthorship W4313561610A5020507966 @default.
- W4313561610 hasAuthorship W4313561610A5025197980 @default.
- W4313561610 hasAuthorship W4313561610A5031606054 @default.
- W4313561610 hasAuthorship W4313561610A5034120381 @default.
- W4313561610 hasAuthorship W4313561610A5037927181 @default.
- W4313561610 hasAuthorship W4313561610A5039660156 @default.
- W4313561610 hasAuthorship W4313561610A5050352383 @default.