Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313561630> ?p ?o ?g. }
- W4313561630 endingPage "110588" @default.
- W4313561630 startingPage "110588" @default.
- W4313561630 abstract "The receptor tyrosine kinase orphan receptor 1 (ROR1) is a receptor for WNT5A and related Wnt proteins, that play an important role during embryonic development by regulating cell migration, cell polarity, neural patterning, and organogenesis. ROR1 exerts these functions by transducing signals from the Wnt secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways. Investigations in adult human cells, particularly cancer cells, have demonstrated that besides these two pathways, the WNT5A/ROR1 axis can activate a number of signaling pathways, including the PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways. Moreover, ROR1 is aberrantly expressed in cancer and was associated with tumor progression and poor survival by promoting cell proliferation, survival, invasion, epithelial to mesenchymal transition, and metastasis. Consequently, numerous therapeutic tools to target ROR1 are currently being evaluated in cancer patients. In this review, we will provide a detailed description of the signaling pathways regulated by ROR1 in cancer and their impact in tumor progression." @default.
- W4313561630 created "2023-01-06" @default.
- W4313561630 creator A5083437066 @default.
- W4313561630 creator A5090366670 @default.
- W4313561630 date "2023-04-01" @default.
- W4313561630 modified "2023-10-18" @default.
- W4313561630 title "The signaling pathways activated by ROR1 in cancer" @default.
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