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- W4313561944 abstract "In this research, sol gel method (xerogel) was utilized to investigate the release of encapsulated Montelukast drug in silica matrix. Encapsulation of montelukast was examined in the presence of various parameters such as temperature, loading rates and type of montelukast salt (Sodium or imidazolium). The findings showed that the best conditions for drug release are achieved in the presence of montelukast sodium salt and at room temperature. The releasing data of montelukast sodium and imidazolium were studied using mathematical kinetic models such as zero, first degree, Higuchi and Korsemeyer-Peppas. The results shown that the kinetic model of Montelukast sodium is Kerosmayer-Peppas, and montelukast imidazolium is Higuchi. For the characterization of sol–gel process and encapsulation of drug in silica matrix a number of different analyses including thermal decomposition (TGA), Fourier transform infrared spectroscopy (FT- IR), transient electron microscopy (TEM), and N2 adsorbtion-desorbtion (BET) were employed. UV spectrophotometry was utilized to determine releasing of drug at different times at 287 nm. The mechanism of drug release is a combination of dissolution and diffusion processes." @default.
- W4313561944 created "2023-01-06" @default.
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- W4313561944 date "2023-03-01" @default.
- W4313561944 modified "2023-10-18" @default.
- W4313561944 title "Silica xerogel carrier as encapsulating Material for the in-vitro controlled release of montelukast" @default.
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- W4313561944 doi "https://doi.org/10.1016/j.inoche.2022.110378" @default.
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