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- W4313561945 abstract "Abstract Objective We aim to summarized and analyzed characteristics of Multiple Endocrine Neoplasia type 1 (MEN-1) or Multiple Endocrine Neoplasia type 2 (MEN-2) cases with other malignant tumors which not belong to MEN components. Methods The clinical data from patients with MEN-1 or MEN-2 in Peking Union Medical College Hospital from April 2012 to April 2022 were collected. Mutations of MEN1 or RET were identified by Sanger sequencing or MLPA in MEN-1 or MEN-2 patients who were diagnosed with malignant tumors which not belong to MEN-1 components. Results A total of 221 patients were diagnosed of MEN-1, in which, 23(11.61%) patients were found to have malignant tumors not belong to MEN-1 components, including papillary thyroid carcinoma (4.52%), breast cancer (1.81%), urologic neoplasms (1.35%), Primary hepatic carcinoma (0.09%), meningeal sarcoma(0.05%), glioblastoma(0.05%), cervical cancer (0.05%), lung carcinoma（0.05%. The prevalence of endocrine neoplasm especially gastroenteropancreatic neuroendocrine tumors were higher in MEN-1 patients with other malignant tumors compared to MEN-1 patients without malignant tumors. 76 patients were diagnosed of MEN-2, 2 (2.63%) patients were identified with papillary thyroid carcinoma and lung cancer respectively. Conclusion MEN-1 patients have a higher risk of developing malignant tumors than the general population, especially breast cancer, papillary thyroid carcinoma and urologic neoplasms. The specific mechanism is still unclear, but the clinical manifestations of MEN-1 patients with malignant tumors were more severe than those without malignant tumors." @default.
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- W4313561945 date "2023-01-05" @default.
- W4313561945 modified "2023-09-27" @default.
- W4313561945 title "Multiple endocrine neoplasia may have an increased risk of other cancers？—Clinical characteristics of Multiple endocrine neoplasia type 1 or 2 patients with malignant tumors" @default.
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- W4313561945 doi "https://doi.org/10.21203/rs.3.rs-2388785/v1" @default.
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