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- W4313562099 endingPage "101842" @default.
- W4313562099 startingPage "101842" @default.
- W4313562099 abstract "With increasing age, bone tissue undergoes significant alterations in composition, architecture, and metabolic functions, probably causing senile osteoporosis. Osteoporosis possess the vast majority of bone disease and associates with a reduction in bone mass and increased fracture risk. Bone loss is on account of the disorder in osteoblast-induced bone formation and osteoclast-induced bone resorption. As a unique bone resorptive cell type, mature bone-resorbing osteoclasts exhibit dynamic actin-based cytoskeletal structures called podosomes that participate in cell-matrix adhesions specialized in the degradation of mineralized bone matrix. Podosomes share many of the same molecular constitutions as focal adhesions, but they have a unique structural organization, with a central core abundant in F-actin and encircled by scaffolding proteins, kinases and integrins. Here, we conclude recent advancements in our knowledge of the architecture and the functions of podosomes. We also discuss the regulatory pathways in osteoclast podosomes, providing a reference for future research on the podosomes of osteoclasts and considering podosomes as a therapeutic target for inhibiting bone resorption." @default.
- W4313562099 created "2023-01-06" @default.
- W4313562099 creator A5023658502 @default.
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- W4313562099 creator A5070992342 @default.
- W4313562099 creator A5073124245 @default.
- W4313562099 creator A5079738340 @default.
- W4313562099 creator A5087657348 @default.
- W4313562099 date "2023-03-01" @default.
- W4313562099 modified "2023-10-16" @default.
- W4313562099 title "Physiological functions of podosomes: From structure and function to therapy implications in osteoclast biology of bone resorption" @default.
- W4313562099 cites W1668085705 @default.
- W4313562099 cites W1757602702 @default.
- W4313562099 cites W1899517398 @default.
- W4313562099 cites W1966064911 @default.
- W4313562099 cites W1967502057 @default.
- W4313562099 cites W1968089570 @default.
- W4313562099 cites W1968832830 @default.
- W4313562099 cites W1971219606 @default.
- W4313562099 cites W1971887776 @default.
- W4313562099 cites W1973281035 @default.
- W4313562099 cites W1974688989 @default.
- W4313562099 cites W1975055486 @default.
- W4313562099 cites W1977461892 @default.
- W4313562099 cites W1985260515 @default.
- W4313562099 cites W1985318253 @default.
- W4313562099 cites W1986167683 @default.
- W4313562099 cites W1991227464 @default.
- W4313562099 cites W1991581759 @default.
- W4313562099 cites W1992166679 @default.
- W4313562099 cites W2000170431 @default.
- W4313562099 cites W2000304973 @default.
- W4313562099 cites W2000824711 @default.
- W4313562099 cites W2002779737 @default.
- W4313562099 cites W2005533362 @default.
- W4313562099 cites W2007925869 @default.
- W4313562099 cites W2008546340 @default.
- W4313562099 cites W2008753012 @default.
- W4313562099 cites W2010806001 @default.
- W4313562099 cites W2019146941 @default.
- W4313562099 cites W2019545214 @default.
- W4313562099 cites W2019731805 @default.
- W4313562099 cites W2019985975 @default.
- W4313562099 cites W2021673391 @default.
- W4313562099 cites W2021882134 @default.
- W4313562099 cites W2021996881 @default.
- W4313562099 cites W2023715743 @default.
- W4313562099 cites W2026266643 @default.
- W4313562099 cites W2034141383 @default.
- W4313562099 cites W2037602068 @default.
- W4313562099 cites W2038458678 @default.
- W4313562099 cites W2039325880 @default.
- W4313562099 cites W2041025244 @default.
- W4313562099 cites W2041119659 @default.
- W4313562099 cites W2041924766 @default.
- W4313562099 cites W2042491330 @default.
- W4313562099 cites W2046831018 @default.
- W4313562099 cites W2047169413 @default.
- W4313562099 cites W2051038367 @default.
- W4313562099 cites W2055206081 @default.
- W4313562099 cites W2057570836 @default.
- W4313562099 cites W2058844752 @default.
- W4313562099 cites W2059877441 @default.
- W4313562099 cites W2060370047 @default.
- W4313562099 cites W2061955515 @default.
- W4313562099 cites W2062191082 @default.
- W4313562099 cites W2063165196 @default.
- W4313562099 cites W2069475390 @default.
- W4313562099 cites W2069820450 @default.
- W4313562099 cites W2071236334 @default.
- W4313562099 cites W2071831995 @default.
- W4313562099 cites W2072941771 @default.
- W4313562099 cites W2075092432 @default.
- W4313562099 cites W2075356469 @default.
- W4313562099 cites W2076192047 @default.
- W4313562099 cites W2077386452 @default.
- W4313562099 cites W2079149769 @default.
- W4313562099 cites W2081301424 @default.
- W4313562099 cites W2082347093 @default.
- W4313562099 cites W2082869839 @default.
- W4313562099 cites W2084073099 @default.
- W4313562099 cites W2084819879 @default.
- W4313562099 cites W2087769364 @default.
- W4313562099 cites W2093944991 @default.
- W4313562099 cites W2096807425 @default.
- W4313562099 cites W2099925679 @default.
- W4313562099 cites W2118078689 @default.
- W4313562099 cites W2118567646 @default.
- W4313562099 cites W2119901759 @default.
- W4313562099 cites W2126838501 @default.
- W4313562099 cites W2130441255 @default.