FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313562260> ?p ?o ?g. }

• W4313562260 endingPage "327756" @default.
• W4313562260 startingPage "gutjnl" @default.
• W4313562260 abstract "Objective Gut microbiota dysbiosis is closely linked to the pathogenesis of rheumatoid arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the development of RA. Design Microbiota profiling in patients with RA and healthy individuals was investigated via 16S rDNA bacterial gene sequencing and shotgun metagenomics. Collagen-induced arthritic mice and TNF-α transgenic mice were used to evaluate the roles of the gut commensal Parabacteroides distasonis in RA. The effects of P. distasonis -derived microbial metabolites on the differentiation of CD4 + T cells and macrophage polarisation were also investigated. Results The relative abundance of P. distasonis in new-onset patients with RA and patients with RA with history of the disease was downregulated and this decrease was negatively correlated with Disease Activity Score-28 (DAS28). Oral treatment of arthritic mice with live P. distasonis (LPD) considerably ameliorated RA pathogenesis. LPD-derived lithocholic acid (LCA), deoxycholic acid (DCA), isolithocholic acid (isoLCA) and 3-oxolithocholic acid (3-oxoLCA) had similar and synergistic effects on the treatment of RA. In addition to directly inhibiting the differentiation of Th17 cells, 3-oxoLCA and isoLCA were identified as TGR5 agonists that promoted the M2 polarisation of macrophages. A specific synthetic inhibitor of bile salt hydrolase attenuated the antiarthritic effects of LPD by reducing the production of these four bile acids. The natural product ginsenoside Rg2 exhibited its anti-RA effects by promoting the growth of P. distasonis . Conclusions P. distasonis and ginsenoside Rg2 might represent probiotic and prebiotic agents in the treatment of RA." @default.
• W4313562260 created "2023-01-06" @default.
• W4313562260 creator A5001618242 @default.
• W4313562260 creator A5011982597 @default.
• W4313562260 creator A5013817406 @default.
• W4313562260 creator A5014451088 @default.
• W4313562260 creator A5014662453 @default.
• W4313562260 creator A5019633223 @default.
• W4313562260 creator A5022682576 @default.
• W4313562260 creator A5024836712 @default.
• W4313562260 creator A5025526709 @default.
• W4313562260 creator A5033803412 @default.
• W4313562260 creator A5037986178 @default.
• W4313562260 creator A5043329797 @default.
• W4313562260 creator A5043778993 @default.
• W4313562260 creator A5049524126 @default.
• W4313562260 creator A5057535469 @default.
• W4313562260 creator A5058437556 @default.
• W4313562260 creator A5058696745 @default.
• W4313562260 creator A5063103434 @default.
• W4313562260 creator A5063511354 @default.
• W4313562260 creator A5067652312 @default.
• W4313562260 creator A5071093853 @default.
• W4313562260 creator A5078581882 @default.
• W4313562260 creator A5079444629 @default.
• W4313562260 creator A5080706041 @default.
• W4313562260 creator A5085418650 @default.
• W4313562260 date "2023-01-05" @default.
• W4313562260 modified "2023-10-01" @default.
• W4313562260 title "Gut commensal<i>Parabacteroides distasonis</i>alleviates inflammatory arthritis" @default.
• W4313562260 cites W1484372612 @default.
• W4313562260 cites W1984242962 @default.
• W4313562260 cites W1984877985 @default.
• W4313562260 cites W1997430037 @default.
• W4313562260 cites W2025375121 @default.
• W4313562260 cites W2134153423 @default.
• W4313562260 cites W2155402987 @default.
• W4313562260 cites W2156730364 @default.
• W4313562260 cites W2169364567 @default.
• W4313562260 cites W2428595929 @default.
• W4313562260 cites W2461427666 @default.
• W4313562260 cites W2554128311 @default.
• W4313562260 cites W2559003643 @default.
• W4313562260 cites W2559113078 @default.
• W4313562260 cites W2790669451 @default.
• W4313562260 cites W2800669841 @default.
• W4313562260 cites W2906742147 @default.
• W4313562260 cites W2959117623 @default.
• W4313562260 cites W2990182987 @default.
• W4313562260 cites W3004986543 @default.
• W4313562260 cites W3032894666 @default.
• W4313562260 cites W3112849870 @default.
• W4313562260 cites W3134475720 @default.
• W4313562260 cites W3136554380 @default.
• W4313562260 cites W3177595964 @default.
• W4313562260 cites W3184541229 @default.
• W4313562260 cites W3212845047 @default.
• W4313562260 cites W4200186639 @default.
• W4313562260 cites W4210642610 @default.
• W4313562260 cites W4214671658 @default.
• W4313562260 cites W4221131751 @default.
• W4313562260 cites W4294204323 @default.
• W4313562260 doi "https://doi.org/10.1136/gutjnl-2022-327756" @default.
• W4313562260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36604114" @default.
• W4313562260 hasPublicationYear "2023" @default.
• W4313562260 type Work @default.
• W4313562260 citedByCount "14" @default.
• W4313562260 countsByYear W43135622602023 @default.
• W4313562260 crossrefType "journal-article" @default.
• W4313562260 hasAuthorship W4313562260A5001618242 @default.
• W4313562260 hasAuthorship W4313562260A5011982597 @default.
• W4313562260 hasAuthorship W4313562260A5013817406 @default.
• W4313562260 hasAuthorship W4313562260A5014451088 @default.
• W4313562260 hasAuthorship W4313562260A5014662453 @default.
• W4313562260 hasAuthorship W4313562260A5019633223 @default.
• W4313562260 hasAuthorship W4313562260A5022682576 @default.
• W4313562260 hasAuthorship W4313562260A5024836712 @default.
• W4313562260 hasAuthorship W4313562260A5025526709 @default.
• W4313562260 hasAuthorship W4313562260A5033803412 @default.
• W4313562260 hasAuthorship W4313562260A5037986178 @default.
• W4313562260 hasAuthorship W4313562260A5043329797 @default.
• W4313562260 hasAuthorship W4313562260A5043778993 @default.
• W4313562260 hasAuthorship W4313562260A5049524126 @default.
• W4313562260 hasAuthorship W4313562260A5057535469 @default.
• W4313562260 hasAuthorship W4313562260A5058437556 @default.
• W4313562260 hasAuthorship W4313562260A5058696745 @default.
• W4313562260 hasAuthorship W4313562260A5063103434 @default.
• W4313562260 hasAuthorship W4313562260A5063511354 @default.
• W4313562260 hasAuthorship W4313562260A5067652312 @default.
• W4313562260 hasAuthorship W4313562260A5071093853 @default.
• W4313562260 hasAuthorship W4313562260A5078581882 @default.
• W4313562260 hasAuthorship W4313562260A5079444629 @default.
• W4313562260 hasAuthorship W4313562260A5080706041 @default.
• W4313562260 hasAuthorship W4313562260A5085418650 @default.
• W4313562260 hasConcept C203014093 @default.
• W4313562260 hasConcept C2777165150 @default.
• W4313562260 hasConcept C2780255968 @default.
• W4313562260 hasConcept C523546767 @default.

• next