FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313566098> ?p ?o ?g. }

• W4313566098 endingPage "32" @default.
• W4313566098 startingPage "19" @default.
• W4313566098 abstract "Background. Drug delivery systems (DDS) have demonstrated a significant ability to overcome many of the challenges associated with the delivery of hydrophobic chemotherapeutic compounds to tumor tissues. However, hepatotoxicity and suppression of the hematopoietic system are the key problems in the clinical treatment of cancer by nanoparticle-based DDS that can limit their medical exposure. The aim of this work was to investigate the effect of thiazole derivative N-(5-benzyl-1,3-thiazol-2-yl)-3,5-dimethyl-1-benzofuran-2-carboxamide (BF1) conjugated with PEG-based polymeric nanoparticles (PEG-PN – Th1) on the hepatocytes and blood hematological parameters of mice with grafted NK/Ly. Materials and Methods. The experiments were conducted on white wild-type male mice with grafted NK/Ly lymphoma. Investigated compounds BF1, PEG-PN Th1, and combination of PEG-PN + BF1 (Th2) at a final concentration of 10 μM were added to the liver samples and incubated for 10 minutes. The level of lipid peroxidation products and the level of antioxidant defense system (AOS) enzymes were determined according to the techniques described below. The cytological parameters of blood were investigated after the treatment of mice with BF1 in concentrations of 10 and 20 mg/kg, PEG-PN (20 mg/kg) and Th2 complex (10 mg/kg). On the 14th day of the experiment, blood was taken from all groups and the number of erythrocytes, leukocytes and leukocyte formula were counted. Results. It was reported that neither BF1, PEG-PN, nor their complex Th2 changed the content of lipid peroxidation products or the level of AOS enzymes in hepatocytes from mice with NK/Ly. BF1 (in concentration 10 mg/kg) and PEG-PN + BF1 complex did not change the level of murine erythrocytes compared to Doxorubicin. All investigated compounds, except free PEG-PN, significantly decreased the NK/Ly-triggered leukocytosis and increased the level of small lymphocytes. The NK/Ly lymphoma development led to an increase in the number of neutrophils, while BF1 and its complex with PEG-PN reduced it significantly. Conclusions. BF1 and PEG-PN + BF1 complex had limited negative side effects in the mice with NK/Ly. The investigated compounds were not hepatotoxic toward murine liver cells. Both BF1 and its complex with PEG-PN did not cause any major side effects on the murine blood cells." @default.
• W4313566098 created "2023-01-06" @default.
• W4313566098 creator A5004401140 @default.
• W4313566098 creator A5005178571 @default.
• W4313566098 creator A5054846306 @default.
• W4313566098 creator A5076544769 @default.
• W4313566098 creator A5083145502 @default.
• W4313566098 creator A5084742990 @default.
• W4313566098 date "2022-01-01" @default.
• W4313566098 modified "2023-10-17" @default.
• W4313566098 title "Safety profile of thiazole derivative and its complex with PEG-based polymeric nanoparticles on liver and blood cells in tumor-bearing mice" @default.
• W4313566098 cites W1775749144 @default.
• W4313566098 cites W2047718984 @default.
• W4313566098 cites W2152979527 @default.
• W4313566098 cites W2323418370 @default.
• W4313566098 cites W2526755011 @default.
• W4313566098 cites W2736681439 @default.
• W4313566098 cites W2765372360 @default.
• W4313566098 cites W2977681251 @default.
• W4313566098 cites W2996578935 @default.
• W4313566098 cites W3046431635 @default.
• W4313566098 cites W3088718953 @default.
• W4313566098 cites W3095622147 @default.
• W4313566098 cites W3127444983 @default.
• W4313566098 cites W3164577482 @default.
• W4313566098 cites W3171607833 @default.
• W4313566098 cites W3182248717 @default.
• W4313566098 cites W3216230939 @default.
• W4313566098 cites W4210927047 @default.
• W4313566098 cites W4225565073 @default.
• W4313566098 cites W4283712609 @default.
• W4313566098 doi "https://doi.org/10.30970/sbi.1604.696" @default.
• W4313566098 hasPublicationYear "2022" @default.
• W4313566098 type Work @default.
• W4313566098 citedByCount "0" @default.
• W4313566098 crossrefType "journal-article" @default.
• W4313566098 hasAuthorship W4313566098A5004401140 @default.
• W4313566098 hasAuthorship W4313566098A5005178571 @default.
• W4313566098 hasAuthorship W4313566098A5054846306 @default.
• W4313566098 hasAuthorship W4313566098A5076544769 @default.
• W4313566098 hasAuthorship W4313566098A5083145502 @default.
• W4313566098 hasAuthorship W4313566098A5084742990 @default.
• W4313566098 hasBestOaLocation W43135660981 @default.
• W4313566098 hasConcept C10138342 @default.
• W4313566098 hasConcept C109159458 @default.
• W4313566098 hasConcept C162324750 @default.
• W4313566098 hasConcept C185592680 @default.
• W4313566098 hasConcept C2778004101 @default.
• W4313566098 hasConcept C2778464347 @default.
• W4313566098 hasConcept C2780829032 @default.
• W4313566098 hasConcept C28328180 @default.
• W4313566098 hasConcept C54355233 @default.
• W4313566098 hasConcept C54400483 @default.
• W4313566098 hasConcept C55493867 @default.
• W4313566098 hasConcept C71240020 @default.
• W4313566098 hasConcept C71924100 @default.
• W4313566098 hasConcept C86803240 @default.
• W4313566098 hasConcept C98274493 @default.
• W4313566098 hasConceptScore W4313566098C10138342 @default.
• W4313566098 hasConceptScore W4313566098C109159458 @default.
• W4313566098 hasConceptScore W4313566098C162324750 @default.
• W4313566098 hasConceptScore W4313566098C185592680 @default.
• W4313566098 hasConceptScore W4313566098C2778004101 @default.
• W4313566098 hasConceptScore W4313566098C2778464347 @default.
• W4313566098 hasConceptScore W4313566098C2780829032 @default.
• W4313566098 hasConceptScore W4313566098C28328180 @default.
• W4313566098 hasConceptScore W4313566098C54355233 @default.
• W4313566098 hasConceptScore W4313566098C54400483 @default.
• W4313566098 hasConceptScore W4313566098C55493867 @default.
• W4313566098 hasConceptScore W4313566098C71240020 @default.
• W4313566098 hasConceptScore W4313566098C71924100 @default.
• W4313566098 hasConceptScore W4313566098C86803240 @default.
• W4313566098 hasConceptScore W4313566098C98274493 @default.
• W4313566098 hasIssue "4" @default.
• W4313566098 hasLocation W43135660981 @default.
• W4313566098 hasOpenAccess W4313566098 @default.
• W4313566098 hasPrimaryLocation W43135660981 @default.
• W4313566098 hasRelatedWork W2104324630 @default.
• W4313566098 hasRelatedWork W2121396455 @default.
• W4313566098 hasRelatedWork W2130686696 @default.
• W4313566098 hasRelatedWork W2339842412 @default.
• W4313566098 hasRelatedWork W2396791681 @default.
• W4313566098 hasRelatedWork W2950162592 @default.
• W4313566098 hasRelatedWork W2952177341 @default.
• W4313566098 hasRelatedWork W2953379326 @default.
• W4313566098 hasRelatedWork W3200563672 @default.
• W4313566098 hasRelatedWork W2057087622 @default.
• W4313566098 hasVolume "16" @default.
• W4313566098 isParatext "false" @default.
• W4313566098 isRetracted "false" @default.
• W4313566098 workType "article" @default.