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- W4313571898 endingPage "348" @default.
- W4313571898 startingPage "348" @default.
- W4313571898 abstract "Tyrosine kinase inhibitors (TKIs) with antiangiogenic properties, such as sorafenib, have been the standard choice to systemically treat hepatocellular carcinoma for over a decade. More recently, encouraging results were obtained using immune checkpoint inhibitors, although head-to-head comparisons with sorafenib in phase 3 trials could not demonstrate superiority in terms of overall survival. The IMbrave150 was a breakthrough study that resulted in atezolizumab/bevacizumab, a combination of an antiangiogenic and an immune checkpoint inhibitor, as a new standard of care for advanced HCC. This review discusses the mode of action, clinical efficacy, and biomarker research for both drug classes and for the combination therapy. Moreover, the synergy between atezolizumab and bevacizumab is highlighted, unraveling pathophysiological mechanisms underlying an enhanced anticancer immunity by changing the immunosuppressed to a more immunoreactive tumor microenvironment (TME). This is achieved by upregulation of antigen presentation, upregulation of T-cell proliferation, trafficking and infiltration, impairing recruitment, and proliferation of immunosuppressive cells in the TME. However, more insights are needed to identify biomarkers of response that may improve patient selection and outcome." @default.
- W4313571898 created "2023-01-06" @default.
- W4313571898 creator A5001010553 @default.
- W4313571898 creator A5027723694 @default.
- W4313571898 creator A5036213851 @default.
- W4313571898 creator A5070524913 @default.
- W4313571898 creator A5086693486 @default.
- W4313571898 creator A5088674436 @default.
- W4313571898 date "2023-01-05" @default.
- W4313571898 modified "2023-09-26" @default.
- W4313571898 title "Unraveling the Synergy between Atezolizumab and Bevacizumab for the Treatment of Hepatocellular Carcinoma" @default.
- W4313571898 cites W1603230122 @default.
- W4313571898 cites W1723912710 @default.
- W4313571898 cites W1966726954 @default.
- W4313571898 cites W1971837077 @default.
- W4313571898 cites W1982906652 @default.
- W4313571898 cites W1983517349 @default.
- W4313571898 cites W1992112921 @default.
- W4313571898 cites W1994993231 @default.
- W4313571898 cites W2022914202 @default.
- W4313571898 cites W2028046471 @default.
- W4313571898 cites W2028525116 @default.
- W4313571898 cites W2046623913 @default.
- W4313571898 cites W2052730188 @default.
- W4313571898 cites W2054420426 @default.
- W4313571898 cites W2063342029 @default.
- W4313571898 cites W2067969350 @default.
- W4313571898 cites W2069027997 @default.
- W4313571898 cites W2101459399 @default.
- W4313571898 cites W2102942095 @default.
- W4313571898 cites W2108950512 @default.
- W4313571898 cites W2109666777 @default.
- W4313571898 cites W2115553491 @default.
- W4313571898 cites W2141444851 @default.
- W4313571898 cites W2144177534 @default.
- W4313571898 cites W2150452646 @default.
- W4313571898 cites W2156906256 @default.
- W4313571898 cites W2157262448 @default.
- W4313571898 cites W2163825883 @default.
- W4313571898 cites W2166788033 @default.
- W4313571898 cites W2170845559 @default.
- W4313571898 cites W2277004004 @default.
- W4313571898 cites W2315690141 @default.
- W4313571898 cites W2414943712 @default.
- W4313571898 cites W2494958745 @default.
- W4313571898 cites W2501650640 @default.
- W4313571898 cites W2508020951 @default.
- W4313571898 cites W2511951051 @default.
- W4313571898 cites W2551911481 @default.
- W4313571898 cites W2552346451 @default.
- W4313571898 cites W2560499218 @default.
- W4313571898 cites W2599822883 @default.
- W4313571898 cites W2606367731 @default.
- W4313571898 cites W2726542547 @default.
- W4313571898 cites W2728245744 @default.
- W4313571898 cites W2766865881 @default.
- W4313571898 cites W2775356055 @default.
- W4313571898 cites W2783295481 @default.
- W4313571898 cites W2787358630 @default.
- W4313571898 cites W2791328450 @default.
- W4313571898 cites W2792937256 @default.
- W4313571898 cites W2795100881 @default.
- W4313571898 cites W2804463612 @default.
- W4313571898 cites W2805302875 @default.
- W4313571898 cites W2805592007 @default.
- W4313571898 cites W2809889937 @default.
- W4313571898 cites W2892757136 @default.
- W4313571898 cites W2903104520 @default.
- W4313571898 cites W2908573150 @default.
- W4313571898 cites W2913384788 @default.
- W4313571898 cites W2913745075 @default.
- W4313571898 cites W2943887705 @default.
- W4313571898 cites W2946478054 @default.
- W4313571898 cites W2952311394 @default.
- W4313571898 cites W2957852424 @default.
- W4313571898 cites W2958131887 @default.
- W4313571898 cites W2976901627 @default.
- W4313571898 cites W2981672189 @default.
- W4313571898 cites W2990602950 @default.
- W4313571898 cites W2995515673 @default.
- W4313571898 cites W3011497962 @default.
- W4313571898 cites W3013078623 @default.
- W4313571898 cites W3013874260 @default.
- W4313571898 cites W3016115097 @default.
- W4313571898 cites W3018979351 @default.
- W4313571898 cites W3025022288 @default.
- W4313571898 cites W3033218405 @default.
- W4313571898 cites W3036426939 @default.
- W4313571898 cites W3042364418 @default.
- W4313571898 cites W3045946240 @default.
- W4313571898 cites W3081388035 @default.
- W4313571898 cites W3083058958 @default.
- W4313571898 cites W3089762019 @default.
- W4313571898 cites W3093785879 @default.
- W4313571898 cites W3094602125 @default.
- W4313571898 cites W3096339202 @default.
- W4313571898 cites W3096713247 @default.
- W4313571898 cites W3097074307 @default.