Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313574248> ?p ?o ?g. }
- W4313574248 endingPage "1011" @default.
- W4313574248 startingPage "1011" @default.
- W4313574248 abstract "Tick-borne encephalitis (TBE) is an emerging zoonosis that may cause long-term neurological sequelae or even death. Thus, there is a growing interest in understanding the factors of TBE pathogenesis. Viral genetic determinants may greatly affect the severity and consequences of TBE. In this study, nonstructural protein 1 (NS1) of the tick-borne encephalitis virus (TBEV) was tested as such a determinant. NS1s of three strains with similar neuroinvasiveness belonging to the European, Siberian and Far-Eastern subtypes of TBEV were studied. Transfection of mouse cells with plasmids encoding NS1 of the three TBEV subtypes led to different levels of NS1 protein accumulation in and secretion from the cells. NS1s of TBEV were able to trigger cytokine production either in isolated mouse splenocytes or in mice after delivery of NS1 encoding plasmids. The profile and dynamics of TNF-α, IL-6, IL-10 and IFN-γ differed between the strains. These results demonstrated the involvement of TBEV NS1 in triggering an immune response and indicated the diversity of NS1 as one of the genetic factors of TBEV pathogenicity." @default.
- W4313574248 created "2023-01-06" @default.
- W4313574248 creator A5003457253 @default.
- W4313574248 creator A5017706397 @default.
- W4313574248 creator A5040361482 @default.
- W4313574248 creator A5043439939 @default.
- W4313574248 creator A5062168396 @default.
- W4313574248 creator A5080169726 @default.
- W4313574248 creator A5082818356 @default.
- W4313574248 date "2023-01-05" @default.
- W4313574248 modified "2023-09-27" @default.
- W4313574248 title "Activation of Early Proinflammatory Responses by TBEV NS1 Varies between the Strains of Various Subtypes" @default.
- W4313574248 cites W1551407310 @default.
- W4313574248 cites W1976308168 @default.
- W4313574248 cites W1977517545 @default.
- W4313574248 cites W1990130249 @default.
- W4313574248 cites W1993620610 @default.
- W4313574248 cites W2028562406 @default.
- W4313574248 cites W2030423864 @default.
- W4313574248 cites W2030481779 @default.
- W4313574248 cites W2034291473 @default.
- W4313574248 cites W2040407633 @default.
- W4313574248 cites W2041511615 @default.
- W4313574248 cites W2041656893 @default.
- W4313574248 cites W2073208133 @default.
- W4313574248 cites W2077946931 @default.
- W4313574248 cites W2081069064 @default.
- W4313574248 cites W2092486828 @default.
- W4313574248 cites W2102376962 @default.
- W4313574248 cites W2103052641 @default.
- W4313574248 cites W2114022608 @default.
- W4313574248 cites W2126129198 @default.
- W4313574248 cites W2128694535 @default.
- W4313574248 cites W2138357746 @default.
- W4313574248 cites W2159940244 @default.
- W4313574248 cites W2166505644 @default.
- W4313574248 cites W2172031283 @default.
- W4313574248 cites W2178559328 @default.
- W4313574248 cites W2198678042 @default.
- W4313574248 cites W2310945373 @default.
- W4313574248 cites W2328041195 @default.
- W4313574248 cites W2337614832 @default.
- W4313574248 cites W2345148984 @default.
- W4313574248 cites W2408955848 @default.
- W4313574248 cites W2418317794 @default.
- W4313574248 cites W2467212161 @default.
- W4313574248 cites W2504596968 @default.
- W4313574248 cites W2550595675 @default.
- W4313574248 cites W2579472273 @default.
- W4313574248 cites W2587183995 @default.
- W4313574248 cites W2806075828 @default.
- W4313574248 cites W2807576102 @default.
- W4313574248 cites W2808197656 @default.
- W4313574248 cites W2883034264 @default.
- W4313574248 cites W2883372641 @default.
- W4313574248 cites W2884914606 @default.
- W4313574248 cites W2912806520 @default.
- W4313574248 cites W2914167396 @default.
- W4313574248 cites W2946615038 @default.
- W4313574248 cites W2953534661 @default.
- W4313574248 cites W2982586220 @default.
- W4313574248 cites W3034554645 @default.
- W4313574248 cites W3095937362 @default.
- W4313574248 cites W3099200429 @default.
- W4313574248 cites W3164398008 @default.
- W4313574248 cites W3166525475 @default.
- W4313574248 cites W3186870402 @default.
- W4313574248 cites W4251714454 @default.
- W4313574248 cites W4281636067 @default.
- W4313574248 cites W4282924272 @default.
- W4313574248 cites W4295359186 @default.
- W4313574248 cites W4307623911 @default.
- W4313574248 cites W4376999661 @default.
- W4313574248 doi "https://doi.org/10.3390/ijms24021011" @default.
- W4313574248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36674524" @default.
- W4313574248 hasPublicationYear "2023" @default.
- W4313574248 type Work @default.
- W4313574248 citedByCount "0" @default.
- W4313574248 crossrefType "journal-article" @default.
- W4313574248 hasAuthorship W4313574248A5003457253 @default.
- W4313574248 hasAuthorship W4313574248A5017706397 @default.
- W4313574248 hasAuthorship W4313574248A5040361482 @default.
- W4313574248 hasAuthorship W4313574248A5043439939 @default.
- W4313574248 hasAuthorship W4313574248A5062168396 @default.
- W4313574248 hasAuthorship W4313574248A5080169726 @default.
- W4313574248 hasAuthorship W4313574248A5082818356 @default.
- W4313574248 hasBestOaLocation W43135742481 @default.
- W4313574248 hasConcept C159047783 @default.
- W4313574248 hasConcept C164027704 @default.
- W4313574248 hasConcept C203014093 @default.
- W4313574248 hasConcept C2522874641 @default.
- W4313574248 hasConcept C2776281056 @default.
- W4313574248 hasConcept C2776914184 @default.
- W4313574248 hasConcept C2779404267 @default.
- W4313574248 hasConcept C2780942790 @default.
- W4313574248 hasConcept C83455156 @default.
- W4313574248 hasConcept C86803240 @default.
- W4313574248 hasConcept C8891405 @default.