FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313574289> ?p ?o ?g. }

• W4313574289 abstract "Background: Shenxiong Glucose Injection (SGI) is a traditional Chinese medicine formula composed of ligustrazine hydrochloride and Danshen (Radix et rhizoma Salviae miltiorrhizae ; Salvia miltiorrhiza Bunge, Lamiaceae). Our previous studies and others have shown that SGI has excellent therapeutic effects on myocardial ischemia (MI). However, the potential mechanisms of action have yet to be elucidated. This study aimed to explore the molecular mechanism of SGI in MI treatment. Methods: Sprague-Dawley rats were treated with isoproterenol (ISO) to establish the MI model. Electrocardiograms, hemodynamic parameters, echocardiograms, reactive oxygen species (ROS) levels, and serum concentrations of cardiac troponin I (cTnI) and cardiac troponin T (cTnT) were analyzed to explore the protective effect of SGI on MI. In addition, a model of oxidative damage and apoptosis in human umbilical vein endothelial cells (HUVECs) was established using CoCl 2 . Cell viability, Ca 2+ concentration, mitochondrial membrane potential (MMP), apoptosis, intracellular ROS, and cell cycle parameters were detected in the HUVEC model. The expression of apoptosis-related proteins (Bcl-2, Caspase-3, PARP, cytoplasmic and mitochondrial Cyt-c and Bax, and p-ERK1/2) was determined by western blotting, and the expression of cleaved caspase-3 was analyzed by immunofluorescence. Results: SGI significantly reduced ROS production and serum concentrations of cTnI and cTnT, reversed ST-segment elevation, and attenuated the deterioration of left ventricular function in ISO-induced MI rats. In vitro , SGI treatment significantly inhibited intracellular ROS overexpression, Ca 2+ influx, MMP disruption, and G2/M arrest in the cell cycle. Additionally, SGI treatment markedly upregulated the expression of anti-apoptotic protein Bcl-2 and downregulated the expression of pro-apoptotic proteins p-ERK1/2, mitochondrial Bax, cytoplasmic Cyt-c, cleaved caspase-3, and PARP. Conclusion: SGI could improve MI by inhibiting the oxidative stress and apoptosis signaling pathways. These findings provide evidence to explain the pharmacological action and underlying molecular mechanisms of SGI in the treatment of MI." @default.
• W4313574289 created "2023-01-06" @default.
• W4313574289 creator A5000503487 @default.
• W4313574289 creator A5018884180 @default.
• W4313574289 creator A5025592380 @default.
• W4313574289 creator A5034711601 @default.
• W4313574289 creator A5036640081 @default.
• W4313574289 creator A5041974203 @default.
• W4313574289 creator A5063089557 @default.
• W4313574289 creator A5069213847 @default.
• W4313574289 creator A5076959779 @default.
• W4313574289 creator A5084135459 @default.
• W4313574289 date "2023-01-05" @default.
• W4313574289 modified "2023-10-14" @default.
• W4313574289 title "Shenxiong glucose injection inhibits oxidative stress and apoptosis to ameliorate isoproterenol-induced myocardial ischemia in rats and improve the function of HUVECs exposed to CoCl2" @default.
• W4313574289 cites W1990202700 @default.
• W4313574289 cites W2040141951 @default.
• W4313574289 cites W2060480383 @default.
• W4313574289 cites W2088056870 @default.
• W4313574289 cites W2157627870 @default.
• W4313574289 cites W2194357501 @default.
• W4313574289 cites W2285347461 @default.
• W4313574289 cites W2530199167 @default.
• W4313574289 cites W2564608154 @default.
• W4313574289 cites W2769416391 @default.
• W4313574289 cites W2773292660 @default.
• W4313574289 cites W2774414544 @default.
• W4313574289 cites W2789078779 @default.
• W4313574289 cites W2790745830 @default.
• W4313574289 cites W2800194932 @default.
• W4313574289 cites W2801071735 @default.
• W4313574289 cites W2807066155 @default.
• W4313574289 cites W2887900345 @default.
• W4313574289 cites W2888543854 @default.
• W4313574289 cites W2905039795 @default.
• W4313574289 cites W2908504121 @default.
• W4313574289 cites W2910412942 @default.
• W4313574289 cites W2922047730 @default.
• W4313574289 cites W2943705760 @default.
• W4313574289 cites W2946181872 @default.
• W4313574289 cites W2948336144 @default.
• W4313574289 cites W2955137120 @default.
• W4313574289 cites W2973533292 @default.
• W4313574289 cites W2974986275 @default.
• W4313574289 cites W2979340870 @default.
• W4313574289 cites W2984091023 @default.
• W4313574289 cites W3001853521 @default.
• W4313574289 cites W3011459566 @default.
• W4313574289 cites W3014321921 @default.
• W4313574289 cites W3083864564 @default.
• W4313574289 cites W3093372352 @default.
• W4313574289 cites W3093590247 @default.
• W4313574289 cites W3118523419 @default.
• W4313574289 cites W3136305307 @default.
• W4313574289 cites W3151800965 @default.
• W4313574289 cites W3180591818 @default.
• W4313574289 cites W3192043106 @default.
• W4313574289 cites W3211966702 @default.
• W4313574289 cites W3215428782 @default.
• W4313574289 cites W3216560702 @default.
• W4313574289 cites W4200091679 @default.
• W4313574289 cites W4205406986 @default.
• W4313574289 cites W4206618827 @default.
• W4313574289 cites W4230914943 @default.
• W4313574289 cites W4280551863 @default.
• W4313574289 cites W4283446835 @default.
• W4313574289 cites W4285030959 @default.
• W4313574289 doi "https://doi.org/10.3389/fphar.2022.931811" @default.
• W4313574289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36686658" @default.
• W4313574289 hasPublicationYear "2023" @default.
• W4313574289 type Work @default.
• W4313574289 citedByCount "0" @default.
• W4313574289 crossrefType "journal-article" @default.
• W4313574289 hasAuthorship W4313574289A5000503487 @default.
• W4313574289 hasAuthorship W4313574289A5018884180 @default.
• W4313574289 hasAuthorship W4313574289A5025592380 @default.
• W4313574289 hasAuthorship W4313574289A5034711601 @default.
• W4313574289 hasAuthorship W4313574289A5036640081 @default.
• W4313574289 hasAuthorship W4313574289A5041974203 @default.
• W4313574289 hasAuthorship W4313574289A5063089557 @default.
• W4313574289 hasAuthorship W4313574289A5069213847 @default.
• W4313574289 hasAuthorship W4313574289A5076959779 @default.
• W4313574289 hasAuthorship W4313574289A5084135459 @default.
• W4313574289 hasBestOaLocation W43135742891 @default.
• W4313574289 hasConcept C115725540 @default.
• W4313574289 hasConcept C126322002 @default.
• W4313574289 hasConcept C142724271 @default.
• W4313574289 hasConcept C185592680 @default.
• W4313574289 hasConcept C188947578 @default.
• W4313574289 hasConcept C190283241 @default.
• W4313574289 hasConcept C195794163 @default.
• W4313574289 hasConcept C204787440 @default.
• W4313574289 hasConcept C2776108454 @default.
• W4313574289 hasConcept C2776151105 @default.
• W4313574289 hasConcept C2776332195 @default.
• W4313574289 hasConcept C48349386 @default.
• W4313574289 hasConcept C500558357 @default.
• W4313574289 hasConcept C53227056 @default.
• W4313574289 hasConcept C55493867 @default.
• W4313574289 hasConcept C62478195 @default.

• next