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- W4313574893 endingPage "105934" @default.
- W4313574893 startingPage "105934" @default.
- W4313574893 abstract "Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family of cytokines, is produced by inflammatory fibroblasts during acute colitis. However, the role of IL-11 in the development of colitis is still unclear. Herein, we showed that IL-11 ameliorated DSS-induced acute colitis in mouse models. We found that deletion of Il11ra1 or Il11 rendered mice highly susceptible to DSS-induced colitis compared to the respective control mice. The number of apoptotic epithelial cells was increased in DSS-treated Il11ra1- or Il11-deficient mice. Moreover, we showed that IL-11 production was regulated by reactive oxygen species (ROS) produced by lysozyme M-positive myeloid cells. These findings indicate that fibroblast-produced IL-11 plays an important role in protecting the mucosal epithelium in acute colitis. Myeloid cell-derived ROS contribute to the attenuation of colitis through the production of IL-11." @default.
- W4313574893 created "2023-01-06" @default.
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- W4313574893 date "2023-02-01" @default.
- W4313574893 modified "2023-09-30" @default.
- W4313574893 title "Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice" @default.
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- W4313574893 doi "https://doi.org/10.1016/j.isci.2023.105934" @default.
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- W4313574893 hasPublicationYear "2023" @default.
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