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• W4313575392 abstract "Abstract Background Atrophic papulosis (Köhlmeier–Degos disease, Degos disease) is a rare thrombo‐obliterative microangiopathy of unknown pathogenesis. It usually affects people between the ages of 20 and 50. However, it can occur at any age. The condition is considered uncommon in children. Objective Clinical characterization of paediatric patients with atrophic papulosis. Methods Single‐centre prospective cohort study with data derived from the international Degos Disease Registry collected between 2000 and 2021. Results Among 96 registered patients with atrophic papulosis fulfilling the criteria, 19 were aged 0 to completed 17 years at the time of onset. The median age at the time of onset was 5 years, ranging from 0 to 1 years for girls to 8 years for boys. In contrast to adult patients (male‐to‐female ratio 1:2.2), there was a male predominance in paediatric patients with a male‐to‐female ratio of 1.7:1. Systemic involvement, in particular gastrointestinal, central nervous system and cardiac, was more frequent in children than in adult patients. There were no statistically significant differences between family history, multisystem involvement, mortality and median survival time in the two groups. Conclusions Atrophic papulosis has some distinct features in the paediatric population. It presents an important and still under‐recognized problem. Therefore, it is mandatory to pay attention to the typical skin lesions in combination with neurological or gastrointestinal symptoms in order to make a prompt and accurate diagnosis." @default.
• W4313575392 created "2023-01-06" @default.
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• W4313575392 date "2023-01-14" @default.
• W4313575392 modified "2023-09-26" @default.
• W4313575392 title "Atrophic papulosis (Köhlmeier–Degos disease) in children and adolescents—A cross–sectional study and literature review" @default.
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• W4313575392 doi "https://doi.org/10.1111/jdv.18844" @default.
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