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- W4313577897 endingPage "204" @default.
- W4313577897 startingPage "204" @default.
- W4313577897 abstract "Numerous recent advancements in T-cell based immunotherapies have revolutionized the treatment of hematologic malignancies. In the race towards the first approved allogeneic cellular therapy product, there is growing interest in utilizing natural killer (NK) cells as a platform for off-the-shelf cellular therapies due to their scalable manufacturing potential, potent anti-tumor efficacy, and superior safety profile. Allogeneic NK cell therapies are now being actively explored in the setting of hematopoietic stem cell transplantation and adoptive transfer. Increasingly sophisticated gene editing techniques have permitted the engineering of chimeric antigen receptors, ectopic cytokine expression, and tumor recognition signals to improve the overall cytotoxicity of NK cell therapies. Furthermore, the enhancement of antibody-dependent cellular cytotoxicity has been achieved through the use of NK cell engagers and combination regimens with monoclonal antibodies that act synergistically with CD16-expressing NK cells. Finally, a greater understanding of NK cell biology and the mechanisms of resistance have allowed the preclinical development of NK checkpoint blockade and methods to modulate the tumor microenvironment, which have been evaluated in early phase trials. This review will discuss the recent clinical advancements in NK cell therapies in hematologic malignancies as well as promising avenues of future research." @default.
- W4313577897 created "2023-01-06" @default.
- W4313577897 creator A5018922885 @default.
- W4313577897 creator A5034639636 @default.
- W4313577897 creator A5071583079 @default.
- W4313577897 date "2022-12-22" @default.
- W4313577897 modified "2023-09-25" @default.
- W4313577897 title "Leveraging Natural Killer Cell Innate Immunity against Hematologic Malignancies: From Stem Cell Transplant to Adoptive Transfer and Beyond" @default.
- W4313577897 cites W1134938859 @default.
- W4313577897 cites W1547437950 @default.
- W4313577897 cites W1828402880 @default.
- W4313577897 cites W1838155222 @default.
- W4313577897 cites W1908894798 @default.
- W4313577897 cites W1965962344 @default.
- W4313577897 cites W1981137720 @default.
- W4313577897 cites W1984515197 @default.
- W4313577897 cites W1989238658 @default.
- W4313577897 cites W1989993418 @default.
- W4313577897 cites W1995224930 @default.
- W4313577897 cites W1998007325 @default.
- W4313577897 cites W2018580749 @default.
- W4313577897 cites W2019813857 @default.
- W4313577897 cites W2023082289 @default.
- W4313577897 cites W2025141198 @default.
- W4313577897 cites W2026654377 @default.
- W4313577897 cites W2043969722 @default.
- W4313577897 cites W2048849656 @default.
- W4313577897 cites W2059208538 @default.
- W4313577897 cites W2075873658 @default.
- W4313577897 cites W2077217249 @default.
- W4313577897 cites W2080826082 @default.
- W4313577897 cites W2090858884 @default.
- W4313577897 cites W2094668841 @default.
- W4313577897 cites W2098394317 @default.
- W4313577897 cites W2102478114 @default.
- W4313577897 cites W2105396692 @default.
- W4313577897 cites W2129003119 @default.
- W4313577897 cites W2146116512 @default.
- W4313577897 cites W2147068163 @default.
- W4313577897 cites W2163255830 @default.
- W4313577897 cites W2164296311 @default.
- W4313577897 cites W2165635676 @default.
- W4313577897 cites W2165813814 @default.
- W4313577897 cites W2165920713 @default.
- W4313577897 cites W2211008635 @default.
- W4313577897 cites W2253944138 @default.
- W4313577897 cites W2258216786 @default.
- W4313577897 cites W2260702256 @default.
- W4313577897 cites W2264802194 @default.
- W4313577897 cites W2333306614 @default.
- W4313577897 cites W2399278955 @default.
- W4313577897 cites W2417517756 @default.
- W4313577897 cites W2427220064 @default.
- W4313577897 cites W2483403462 @default.
- W4313577897 cites W2501460328 @default.
- W4313577897 cites W2515527586 @default.
- W4313577897 cites W2521461373 @default.
- W4313577897 cites W2546678429 @default.
- W4313577897 cites W2556149828 @default.
- W4313577897 cites W2559827832 @default.
- W4313577897 cites W2572765595 @default.
- W4313577897 cites W2576002405 @default.
- W4313577897 cites W2594882747 @default.
- W4313577897 cites W2599506479 @default.
- W4313577897 cites W2671342613 @default.
- W4313577897 cites W2735011415 @default.
- W4313577897 cites W2738977754 @default.
- W4313577897 cites W2750168879 @default.
- W4313577897 cites W2753081026 @default.
- W4313577897 cites W2763653175 @default.
- W4313577897 cites W2766229434 @default.
- W4313577897 cites W2768639020 @default.
- W4313577897 cites W2774014792 @default.
- W4313577897 cites W2788914092 @default.
- W4313577897 cites W2789533682 @default.
- W4313577897 cites W2791048627 @default.
- W4313577897 cites W2794185992 @default.
- W4313577897 cites W2795056814 @default.
- W4313577897 cites W2800095326 @default.
- W4313577897 cites W2801354368 @default.
- W4313577897 cites W2808265051 @default.
- W4313577897 cites W2808601843 @default.
- W4313577897 cites W2808995183 @default.
- W4313577897 cites W2810715813 @default.
- W4313577897 cites W2885605094 @default.
- W4313577897 cites W2890056446 @default.
- W4313577897 cites W2890113688 @default.
- W4313577897 cites W2890499629 @default.
- W4313577897 cites W2893585523 @default.
- W4313577897 cites W2903062212 @default.
- W4313577897 cites W2909334052 @default.
- W4313577897 cites W2909867289 @default.
- W4313577897 cites W2910701797 @default.
- W4313577897 cites W2912113425 @default.
- W4313577897 cites W2913250085 @default.
- W4313577897 cites W2913289941 @default.
- W4313577897 cites W2913598126 @default.
- W4313577897 cites W2915026453 @default.