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- W4313578554 startingPage "158" @default.
- W4313578554 abstract "The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae. Animal models have historically been important to study virus pathogenicity and to develop medical countermeasures. As these have inherent shortcomings, the rise of microphysiological systems and organoids able to recapitulate hallmarks of the diseases caused by these viruses may have enormous potential to add to or partially replace animal modeling in the future. Indeed, microphysiological systems and organoids are already used in the pharmaceutical R&D pipeline because they are prefigured to overcome the translational gap between model systems and clinical studies. Moreover, they may serve to alleviate ethical concerns related to animal research. In this review, we discuss the value of animal model alternatives in human pathogenic filovirus and bornavirus research. The current animal models and their limitations are presented followed by an overview of existing alternatives, such as organoids and microphysiological systems, which might help answering open research questions." @default.
- W4313578554 created "2023-01-06" @default.
- W4313578554 creator A5013082973 @default.
- W4313578554 creator A5055444631 @default.
- W4313578554 creator A5080168059 @default.
- W4313578554 creator A5090054057 @default.
- W4313578554 date "2023-01-04" @default.
- W4313578554 modified "2023-10-04" @default.
- W4313578554 title "Animal Model Alternatives in Filovirus and Bornavirus Research" @default.
- W4313578554 cites W1137112069 @default.
- W4313578554 cites W1269781284 @default.
- W4313578554 cites W136387051 @default.
- W4313578554 cites W143989284 @default.
- W4313578554 cites W1501367045 @default.
- W4313578554 cites W1504643362 @default.
- W4313578554 cites W1512126150 @default.
- W4313578554 cites W1538623570 @default.
- W4313578554 cites W1663828542 @default.
- W4313578554 cites W1781829305 @default.
- W4313578554 cites W1830906699 @default.
- W4313578554 cites W1848527143 @default.
- W4313578554 cites W1902122130 @default.
- W4313578554 cites W1937339698 @default.
- W4313578554 cites W1964355702 @default.
- W4313578554 cites W1966242477 @default.
- W4313578554 cites W1968782527 @default.
- W4313578554 cites W1969661655 @default.
- W4313578554 cites W1975525323 @default.
- W4313578554 cites W1978306018 @default.
- W4313578554 cites W1978825518 @default.
- W4313578554 cites W1979665070 @default.
- W4313578554 cites W1982336326 @default.
- W4313578554 cites W1982752306 @default.
- W4313578554 cites W1983352401 @default.
- W4313578554 cites W1986160182 @default.
- W4313578554 cites W1986492410 @default.
- W4313578554 cites W1990670176 @default.
- W4313578554 cites W1995116321 @default.
- W4313578554 cites W1995402852 @default.
- W4313578554 cites W1997519528 @default.
- W4313578554 cites W2002206719 @default.
- W4313578554 cites W2003342013 @default.
- W4313578554 cites W2004044377 @default.
- W4313578554 cites W2004688512 @default.
- W4313578554 cites W2008471607 @default.
- W4313578554 cites W2011395494 @default.
- W4313578554 cites W2013520568 @default.
- W4313578554 cites W2022659608 @default.
- W4313578554 cites W2024172223 @default.
- W4313578554 cites W2024711421 @default.
- W4313578554 cites W2024753278 @default.
- W4313578554 cites W2026908430 @default.
- W4313578554 cites W2028103767 @default.
- W4313578554 cites W2030154807 @default.
- W4313578554 cites W2030250036 @default.
- W4313578554 cites W2033117797 @default.
- W4313578554 cites W2034843298 @default.
- W4313578554 cites W2037151351 @default.
- W4313578554 cites W2038407322 @default.
- W4313578554 cites W2042912875 @default.
- W4313578554 cites W2043110438 @default.
- W4313578554 cites W2044928246 @default.
- W4313578554 cites W2049320958 @default.
- W4313578554 cites W2049611778 @default.
- W4313578554 cites W2049710454 @default.
- W4313578554 cites W2058238342 @default.
- W4313578554 cites W2061656901 @default.
- W4313578554 cites W2062279417 @default.
- W4313578554 cites W2063229757 @default.
- W4313578554 cites W2063277162 @default.
- W4313578554 cites W2065901519 @default.
- W4313578554 cites W2067949384 @default.
- W4313578554 cites W2073132779 @default.
- W4313578554 cites W2073332524 @default.
- W4313578554 cites W2077257157 @default.
- W4313578554 cites W2077925794 @default.
- W4313578554 cites W2078986818 @default.
- W4313578554 cites W2079928928 @default.
- W4313578554 cites W2081520626 @default.
- W4313578554 cites W2083357623 @default.
- W4313578554 cites W2087482145 @default.
- W4313578554 cites W2088980365 @default.
- W4313578554 cites W2090854729 @default.
- W4313578554 cites W2093082279 @default.
- W4313578554 cites W2098255809 @default.
- W4313578554 cites W2098764169 @default.
- W4313578554 cites W2098900577 @default.
- W4313578554 cites W2099191040 @default.
- W4313578554 cites W2101872019 @default.
- W4313578554 cites W2106430003 @default.
- W4313578554 cites W2107341969 @default.
- W4313578554 cites W2109152434 @default.
- W4313578554 cites W2113524394 @default.
- W4313578554 cites W2115174286 @default.
- W4313578554 cites W2115439758 @default.
- W4313578554 cites W2118891207 @default.
- W4313578554 cites W2121706409 @default.
- W4313578554 cites W2121895001 @default.