Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313582045> ?p ?o ?g. }
- W4313582045 endingPage "443" @default.
- W4313582045 startingPage "443" @default.
- W4313582045 abstract "Osthole, a coumarin derivative, is found in several medicinal herbs. However, the protective effects of osthole against D-galactose (D-Gal)-induced liver injury still remain unclear. In this study, osthole treatment effectively reversed D-Gal-induced liver injury, according to the results of liver HE staining, and improved ALT and AST activities. Feeding with D-Gal significantly increased MDA content, and reduced the level or activity of SOD, CAT and GSH-Px, which were all alleviated by osthole intervention. Meanwhile, osthole treatment significantly inhibited the D-Gal-induced secretion of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, in both serum and liver tissue. Investigations revealed that osthole ameliorated the D-Gal-induced activation of TLR4, MYD88 and its downstream signaling pathways of MAPK (p38 and JNK) and NF-κB (nucleus p65). Therefore, osthole mediates a protective effect against D-Gal-induced liver injury via the TLR4/MAPK/NF-κB pathways, and this coumarin derivative could be developed as a candidate bioactive component for functional food." @default.
- W4313582045 created "2023-01-06" @default.
- W4313582045 creator A5007947573 @default.
- W4313582045 creator A5011171384 @default.
- W4313582045 creator A5033631664 @default.
- W4313582045 creator A5068084061 @default.
- W4313582045 creator A5069612314 @default.
- W4313582045 date "2023-01-03" @default.
- W4313582045 modified "2023-10-12" @default.
- W4313582045 title "Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways" @default.
- W4313582045 cites W1995654460 @default.
- W4313582045 cites W1998762886 @default.
- W4313582045 cites W2006856548 @default.
- W4313582045 cites W2031876291 @default.
- W4313582045 cites W2090263578 @default.
- W4313582045 cites W2129381718 @default.
- W4313582045 cites W2135919238 @default.
- W4313582045 cites W2402937561 @default.
- W4313582045 cites W2512859534 @default.
- W4313582045 cites W2526925916 @default.
- W4313582045 cites W2590703851 @default.
- W4313582045 cites W2595165596 @default.
- W4313582045 cites W2787055018 @default.
- W4313582045 cites W2790750213 @default.
- W4313582045 cites W2799962298 @default.
- W4313582045 cites W2888480811 @default.
- W4313582045 cites W2915204262 @default.
- W4313582045 cites W2936381173 @default.
- W4313582045 cites W2940052832 @default.
- W4313582045 cites W2944718957 @default.
- W4313582045 cites W2955374005 @default.
- W4313582045 cites W2965856393 @default.
- W4313582045 cites W2969248757 @default.
- W4313582045 cites W3003064060 @default.
- W4313582045 cites W3003425809 @default.
- W4313582045 cites W3004016745 @default.
- W4313582045 cites W3008188366 @default.
- W4313582045 cites W3038015203 @default.
- W4313582045 cites W3187682326 @default.
- W4313582045 cites W4200545780 @default.
- W4313582045 cites W784225791 @default.
- W4313582045 doi "https://doi.org/10.3390/molecules28010443" @default.
- W4313582045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36615637" @default.
- W4313582045 hasPublicationYear "2023" @default.
- W4313582045 type Work @default.
- W4313582045 citedByCount "3" @default.
- W4313582045 countsByYear W43135820452023 @default.
- W4313582045 crossrefType "journal-article" @default.
- W4313582045 hasAuthorship W4313582045A5007947573 @default.
- W4313582045 hasAuthorship W4313582045A5011171384 @default.
- W4313582045 hasAuthorship W4313582045A5033631664 @default.
- W4313582045 hasAuthorship W4313582045A5068084061 @default.
- W4313582045 hasAuthorship W4313582045A5069612314 @default.
- W4313582045 hasBestOaLocation W43135820451 @default.
- W4313582045 hasConcept C134018914 @default.
- W4313582045 hasConcept C150903083 @default.
- W4313582045 hasConcept C178790620 @default.
- W4313582045 hasConcept C17991360 @default.
- W4313582045 hasConcept C185592680 @default.
- W4313582045 hasConcept C207001950 @default.
- W4313582045 hasConcept C2776070231 @default.
- W4313582045 hasConcept C2776637226 @default.
- W4313582045 hasConcept C2777730290 @default.
- W4313582045 hasConcept C2778173381 @default.
- W4313582045 hasConcept C2781338262 @default.
- W4313582045 hasConcept C51551487 @default.
- W4313582045 hasConcept C55493867 @default.
- W4313582045 hasConcept C57074206 @default.
- W4313582045 hasConcept C62478195 @default.
- W4313582045 hasConcept C71924100 @default.
- W4313582045 hasConcept C86803240 @default.
- W4313582045 hasConcept C98274493 @default.
- W4313582045 hasConceptScore W4313582045C134018914 @default.
- W4313582045 hasConceptScore W4313582045C150903083 @default.
- W4313582045 hasConceptScore W4313582045C178790620 @default.
- W4313582045 hasConceptScore W4313582045C17991360 @default.
- W4313582045 hasConceptScore W4313582045C185592680 @default.
- W4313582045 hasConceptScore W4313582045C207001950 @default.
- W4313582045 hasConceptScore W4313582045C2776070231 @default.
- W4313582045 hasConceptScore W4313582045C2776637226 @default.
- W4313582045 hasConceptScore W4313582045C2777730290 @default.
- W4313582045 hasConceptScore W4313582045C2778173381 @default.
- W4313582045 hasConceptScore W4313582045C2781338262 @default.
- W4313582045 hasConceptScore W4313582045C51551487 @default.
- W4313582045 hasConceptScore W4313582045C55493867 @default.
- W4313582045 hasConceptScore W4313582045C57074206 @default.
- W4313582045 hasConceptScore W4313582045C62478195 @default.
- W4313582045 hasConceptScore W4313582045C71924100 @default.
- W4313582045 hasConceptScore W4313582045C86803240 @default.
- W4313582045 hasConceptScore W4313582045C98274493 @default.
- W4313582045 hasFunder F4320336614 @default.
- W4313582045 hasFunder F4320338464 @default.
- W4313582045 hasIssue "1" @default.
- W4313582045 hasLocation W43135820451 @default.
- W4313582045 hasLocation W43135820452 @default.
- W4313582045 hasLocation W43135820453 @default.
- W4313582045 hasOpenAccess W4313582045 @default.
- W4313582045 hasPrimaryLocation W43135820451 @default.