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• W4313582665 endingPage "956" @default.
• W4313582665 startingPage "956" @default.
• W4313582665 abstract "The use of small interfering RNA (siRNA) in the clinic gives a wide range of possibilities for the treatment of previously incurable diseases. However, the main limitation for biomedical applications is their delivery to target cells and organs. Currently, delivery of siRNA to liver cells is a solved problem due to the bioconjugation of siRNA with N-acetylgalactosamine; other organs remain challenging for siRNA delivery to them. Despite the important role of the ligand in the composition of the bioconjugate, the structure and molecular weight of siRNA also play an important role in the delivery of siRNA. The basic principle is that siRNAs with smaller molecular weights are more efficient at entering cells, whereas siRNAs with larger molecular weights have advantages at the organism level. Here we review the relationships between siRNA structure and its biodistribution and activity to find new strategies for improving siRNA performance." @default.
• W4313582665 created "2023-01-06" @default.
• W4313582665 creator A5028266747 @default.
• W4313582665 creator A5029456753 @default.
• W4313582665 creator A5043128490 @default.
• W4313582665 date "2023-01-04" @default.
• W4313582665 modified "2023-10-06" @default.
• W4313582665 title "Structural Modifications of siRNA Improve Its Performance In Vivo" @default.
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