FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313582801> ?p ?o ?g. }

• W4313582801 endingPage "248" @default.
• W4313582801 startingPage "248" @default.
• W4313582801 abstract "The efficacy and safety of medications can be affected by alterations in gut microbiota in human beings. Among antidiabetic medications, incretin-based therapy such as dipeptidyl peptidase 4 inhibitors might affect gut microbiomes, which are related to glucose metabolism. This was a randomized, controlled, active-competitor study that aimed to compare the effects of combinations of gemigliptin−metformin vs. glimepiride−metformin as initial therapies on gut microbiota and glucose homeostasis in drug-naïve patients with type 2 diabetes. Seventy drug-naïve patients with type 2 diabetes (mean age, 52.2 years) with a glycated hemoglobin (HbA1c) level ≥7.5% were assigned to either gemigliptin−metformin or glimepiride−metformin combination therapies for 24 weeks. Changes in gut microbiota, biomarkers linked to glucose regulation, body composition, and amino acid blood levels were investigated. Although both treatments decreased the HbA1c levels significantly, the gemigliptin−metformin group achieved HbA1c ≤ 7.0% without hypoglycemia or weight gain more effectively than did the glimepiride−metformin group (59% vs. 24%; p < 0.05). At the phylum level, the Firmicutes/Bacteroidetes ratio tended to decrease after gemigliptin−metformin therapy (p = 0.065), with a notable depletion of taxa belonging to Firmicutes, including Lactobacillus, Ruminococcus torques, and Streptococcus (all p < 0.05). However, regardless of the treatment modality, a distinct difference in the overall gut microbiome composition was noted between patients who reached the HbA1c target goal and those who did not (p < 0.001). Treatment with gemigliptin−metformin resulted in a higher achievement of the glycemic target without hypoglycemia or weight gain, better than with glimepiride−metformin; these improvements might be related to beneficial changes in gut microbiota." @default.
• W4313582801 created "2023-01-06" @default.
• W4313582801 creator A5046318848 @default.
• W4313582801 creator A5047478353 @default.
• W4313582801 creator A5056443015 @default.
• W4313582801 creator A5067359287 @default.
• W4313582801 creator A5076935037 @default.
• W4313582801 date "2023-01-03" @default.
• W4313582801 modified "2023-10-18" @default.
• W4313582801 title "Effects of Initial Combinations of Gemigliptin Plus Metformin Compared with Glimepiride Plus Metformin on Gut Microbiota and Glucose Regulation in Obese Patients with Type 2 Diabetes: The INTESTINE Study" @default.
• W4313582801 cites W1877854700 @default.
• W4313582801 cites W2023615726 @default.
• W4313582801 cites W2026388701 @default.
• W4313582801 cites W2041375230 @default.
• W4313582801 cites W2045458218 @default.
• W4313582801 cites W2071841602 @default.
• W4313582801 cites W2073332363 @default.
• W4313582801 cites W2088822458 @default.
• W4313582801 cites W2118708320 @default.
• W4313582801 cites W2124234371 @default.
• W4313582801 cites W2139203772 @default.
• W4313582801 cites W2171294019 @default.
• W4313582801 cites W2173923871 @default.
• W4313582801 cites W2180946184 @default.
• W4313582801 cites W2188930066 @default.
• W4313582801 cites W2235603614 @default.
• W4313582801 cites W2293570834 @default.
• W4313582801 cites W2487142160 @default.
• W4313582801 cites W2510445216 @default.
• W4313582801 cites W2518629454 @default.
• W4313582801 cites W2519704960 @default.
• W4313582801 cites W2560679821 @default.
• W4313582801 cites W2607345063 @default.
• W4313582801 cites W2617940752 @default.
• W4313582801 cites W2756515329 @default.
• W4313582801 cites W2765808908 @default.
• W4313582801 cites W2768026039 @default.
• W4313582801 cites W2806093627 @default.
• W4313582801 cites W2809642430 @default.
• W4313582801 cites W2890120255 @default.
• W4313582801 cites W2898599254 @default.
• W4313582801 cites W2904078035 @default.
• W4313582801 cites W2921890802 @default.
• W4313582801 cites W2924869149 @default.
• W4313582801 cites W2949339806 @default.
• W4313582801 cites W2954211143 @default.
• W4313582801 cites W2974788498 @default.
• W4313582801 cites W2994801819 @default.
• W4313582801 cites W3000095198 @default.
• W4313582801 cites W3008756456 @default.
• W4313582801 cites W3041248404 @default.
• W4313582801 cites W3086213814 @default.
• W4313582801 cites W3097073631 @default.
• W4313582801 cites W3111703679 @default.
• W4313582801 cites W3112932318 @default.
• W4313582801 cites W3142792508 @default.
• W4313582801 cites W3152810664 @default.
• W4313582801 cites W3161603717 @default.
• W4313582801 cites W3174878740 @default.
• W4313582801 cites W3182455671 @default.
• W4313582801 doi "https://doi.org/10.3390/nu15010248" @default.
• W4313582801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36615904" @default.
• W4313582801 hasPublicationYear "2023" @default.
• W4313582801 type Work @default.
• W4313582801 citedByCount "1" @default.
• W4313582801 crossrefType "journal-article" @default.
• W4313582801 hasAuthorship W4313582801A5046318848 @default.
• W4313582801 hasAuthorship W4313582801A5047478353 @default.
• W4313582801 hasAuthorship W4313582801A5056443015 @default.
• W4313582801 hasAuthorship W4313582801A5067359287 @default.
• W4313582801 hasAuthorship W4313582801A5076935037 @default.
• W4313582801 hasBestOaLocation W43135828011 @default.
• W4313582801 hasConcept C126322002 @default.
• W4313582801 hasConcept C134018914 @default.
• W4313582801 hasConcept C203014093 @default.
• W4313582801 hasConcept C2776307423 @default.
• W4313582801 hasConcept C2777180221 @default.
• W4313582801 hasConcept C2777391703 @default.
• W4313582801 hasConcept C2780323712 @default.
• W4313582801 hasConcept C2780473172 @default.
• W4313582801 hasConcept C3018667095 @default.
• W4313582801 hasConcept C539455810 @default.
• W4313582801 hasConcept C555293320 @default.
• W4313582801 hasConcept C71924100 @default.
• W4313582801 hasConcept C98274493 @default.
• W4313582801 hasConceptScore W4313582801C126322002 @default.
• W4313582801 hasConceptScore W4313582801C134018914 @default.
• W4313582801 hasConceptScore W4313582801C203014093 @default.
• W4313582801 hasConceptScore W4313582801C2776307423 @default.
• W4313582801 hasConceptScore W4313582801C2777180221 @default.
• W4313582801 hasConceptScore W4313582801C2777391703 @default.
• W4313582801 hasConceptScore W4313582801C2780323712 @default.
• W4313582801 hasConceptScore W4313582801C2780473172 @default.
• W4313582801 hasConceptScore W4313582801C3018667095 @default.
• W4313582801 hasConceptScore W4313582801C539455810 @default.
• W4313582801 hasConceptScore W4313582801C555293320 @default.
• W4313582801 hasConceptScore W4313582801C71924100 @default.
• W4313582801 hasConceptScore W4313582801C98274493 @default.

• next