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- W4313583872 abstract "Alzheimer’s disease (AD) is an incurable, age-related neurological disorder, the most common form of dementia. Considering that AD is a multifactorial complex disease, simplified experimental models are required for its analysis. For this purpose, genetically modified Yarrowia lipolytica yeast strains expressing Aβ42 (the main biomarker of AD), eGFP-Aβ42, Aβ40, and eGFP-Aβ40 were constructed and examined. In contrast to the cells expressing eGFP and eGFP-Aβ40, retaining “normal” mitochondrial reticulum, eGFP-Aβ42 cells possessed a disturbed mitochondrial reticulum with fragmented mitochondria; this was partially restored by preincubation with a mitochondria-targeted antioxidant SkQThy. Aβ42 expression also elevated ROS production and cell death; low concentrations of SkQThy mitigated these effects. Aβ42 expression caused mitochondrial dysfunction as inferred from a loose coupling of respiration and phosphorylation, the decreased level of ATP production, and the enhanced rate of hydrogen peroxide formation. Therefore, we have obtained the same results described for other AD models. Based on an analysis of these and earlier data, we suggest that the mitochondrial fragmentation might be a biomarker of the earliest preclinical stage of AD with an effective therapy based on mitochondria- targeted antioxidants. The simple yeast model constructed can be a useful platform for the rapid screening of such compounds." @default.
- W4313583872 created "2023-01-06" @default.
- W4313583872 creator A5019536709 @default.
- W4313583872 creator A5029070807 @default.
- W4313583872 creator A5036417465 @default.
- W4313583872 creator A5041557735 @default.
- W4313583872 creator A5069370037 @default.
- W4313583872 creator A5082323737 @default.
- W4313583872 date "2023-01-04" @default.
- W4313583872 modified "2023-10-06" @default.
- W4313583872 title "Altered Mitochondrial Morphology and Bioenergetics in a New Yeast Model Expressing Aβ42" @default.
- W4313583872 cites W1996981671 @default.
- W4313583872 cites W2010925911 @default.
- W4313583872 cites W2024673436 @default.
- W4313583872 cites W2037947871 @default.
- W4313583872 cites W2086783188 @default.
- W4313583872 cites W2088937171 @default.
- W4313583872 cites W2128635872 @default.
- W4313583872 cites W2200046622 @default.
- W4313583872 cites W2526341109 @default.
- W4313583872 cites W2527422074 @default.
- W4313583872 cites W2528945162 @default.
- W4313583872 cites W2602846991 @default.
- W4313583872 cites W2604387140 @default.
- W4313583872 cites W2606684494 @default.
- W4313583872 cites W2607009919 @default.
- W4313583872 cites W2607143731 @default.
- W4313583872 cites W2704196653 @default.
- W4313583872 cites W2735791958 @default.
- W4313583872 cites W2767902257 @default.
- W4313583872 cites W2796036472 @default.
- W4313583872 cites W2798054687 @default.
- W4313583872 cites W2802587814 @default.
- W4313583872 cites W2803794529 @default.
- W4313583872 cites W2811166885 @default.
- W4313583872 cites W2884185358 @default.
- W4313583872 cites W2895430781 @default.
- W4313583872 cites W2902944709 @default.
- W4313583872 cites W2904222299 @default.
- W4313583872 cites W2910576122 @default.
- W4313583872 cites W2911147760 @default.
- W4313583872 cites W2911493122 @default.
- W4313583872 cites W2913840646 @default.
- W4313583872 cites W2921231677 @default.
- W4313583872 cites W2922608917 @default.
- W4313583872 cites W2923105176 @default.
- W4313583872 cites W2925620762 @default.
- W4313583872 cites W2943230223 @default.
- W4313583872 cites W2943469513 @default.
- W4313583872 cites W2954123022 @default.
- W4313583872 cites W2956027385 @default.
- W4313583872 cites W2958163758 @default.
- W4313583872 cites W2965069278 @default.
- W4313583872 cites W2967522161 @default.
- W4313583872 cites W2969925933 @default.
- W4313583872 cites W2971925677 @default.
- W4313583872 cites W2972942048 @default.
- W4313583872 cites W2979180409 @default.
- W4313583872 cites W2979446366 @default.
- W4313583872 cites W2979733507 @default.
- W4313583872 cites W2988412209 @default.
- W4313583872 cites W2996674515 @default.
- W4313583872 cites W2997441766 @default.
- W4313583872 cites W3006131455 @default.
- W4313583872 cites W3006398177 @default.
- W4313583872 cites W3006557860 @default.
- W4313583872 cites W3006871825 @default.
- W4313583872 cites W3011252852 @default.
- W4313583872 cites W3011648583 @default.
- W4313583872 cites W3012955650 @default.
- W4313583872 cites W3015784636 @default.
- W4313583872 cites W3022539327 @default.
- W4313583872 cites W3026807498 @default.
- W4313583872 cites W3030743313 @default.
- W4313583872 cites W3048789142 @default.
- W4313583872 cites W3090426050 @default.
- W4313583872 cites W3091354748 @default.
- W4313583872 cites W3092088846 @default.
- W4313583872 cites W3092301437 @default.
- W4313583872 cites W3094515282 @default.
- W4313583872 cites W3096564080 @default.
- W4313583872 cites W3098909487 @default.
- W4313583872 cites W3111203418 @default.
- W4313583872 cites W3111968574 @default.
- W4313583872 cites W3113356730 @default.
- W4313583872 cites W3120339133 @default.
- W4313583872 cites W3129560832 @default.
- W4313583872 cites W3130988710 @default.
- W4313583872 cites W3132811621 @default.
- W4313583872 cites W3152913705 @default.
- W4313583872 cites W3157263362 @default.
- W4313583872 cites W3158546972 @default.
- W4313583872 cites W3160110415 @default.
- W4313583872 cites W3165307688 @default.
- W4313583872 cites W3165398906 @default.
- W4313583872 cites W3180069668 @default.
- W4313583872 cites W3188734243 @default.
- W4313583872 cites W3193397977 @default.