FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313584079> ?p ?o ?g. }

• W4313584079 endingPage "933" @default.
• W4313584079 startingPage "933" @default.
• W4313584079 abstract "Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. In steroidogenic cells, the required cholesterol for steroidogenesis can be obtained from blood circulation or synthesized de novo from acetate. One of the key enzymes that control cholesterol synthesis is 24-dehydrocholesterol reductase (encoded by DHCR24). In humans and rats, DHCR24 is highly expressed in the adrenal gland, especially in the zona fasciculata. We recently reported that DHCR24 was expressed in the mouse adrenal gland’s inner cortex and also found that thyroid hormone treatment significantly upregulated the expression of Dhcr24 in the mouse adrenal gland. In the present study, we showed the cellular expression of DHCR24 in mouse adrenal glands in early postnatal stages. We found that the expression pattern of DHCR24 was similar to the X-zone marker gene 20αHSD in most developmental stages. This finding indicates that most steroidogenic adrenocortical cells in the mouse adrenal gland do not synthesize cholesterol locally. Unlike the 20αHSD-positive X-zone regresses during pregnancy, some DHCR24-positive cells remain present in parous females. Conditional knockout mice showed that the removal of Dhcr24 in steroidogenic cells did not affect the overall development of the adrenal gland or the secretion of corticosterone under acute stress. Whether DHCR24 plays a role in conditions where a continuous high amount of corticosterone production is needed requires further investigation." @default.
• W4313584079 created "2023-01-06" @default.
• W4313584079 creator A5023661274 @default.
• W4313584079 creator A5029663970 @default.
• W4313584079 creator A5043473548 @default.
• W4313584079 creator A5049141535 @default.
• W4313584079 creator A5067261920 @default.
• W4313584079 creator A5080367407 @default.
• W4313584079 creator A5085137039 @default.
• W4313584079 creator A5085440633 @default.
• W4313584079 creator A5085786569 @default.
• W4313584079 date "2023-01-04" @default.
• W4313584079 modified "2023-10-14" @default.
• W4313584079 title "DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex" @default.
• W4313584079 cites W1534278414 @default.
• W4313584079 cites W1806394871 @default.
• W4313584079 cites W1963827257 @default.
• W4313584079 cites W1974210533 @default.
• W4313584079 cites W1974677280 @default.
• W4313584079 cites W1987517713 @default.
• W4313584079 cites W1988449005 @default.
• W4313584079 cites W1996133111 @default.
• W4313584079 cites W1996778594 @default.
• W4313584079 cites W2004066763 @default.
• W4313584079 cites W2007846402 @default.
• W4313584079 cites W2027156901 @default.
• W4313584079 cites W2069008098 @default.
• W4313584079 cites W2075191006 @default.
• W4313584079 cites W2093801618 @default.
• W4313584079 cites W2094248542 @default.
• W4313584079 cites W2095750495 @default.
• W4313584079 cites W2110985070 @default.
• W4313584079 cites W2111049082 @default.
• W4313584079 cites W2112679085 @default.
• W4313584079 cites W2115190385 @default.
• W4313584079 cites W2125633864 @default.
• W4313584079 cites W2135963922 @default.
• W4313584079 cites W2139657513 @default.
• W4313584079 cites W2140723970 @default.
• W4313584079 cites W2154124976 @default.
• W4313584079 cites W2165451199 @default.
• W4313584079 cites W2737526799 @default.
• W4313584079 cites W2762528753 @default.
• W4313584079 cites W2767903781 @default.
• W4313584079 cites W2770888364 @default.
• W4313584079 cites W2917741054 @default.
• W4313584079 cites W3008434952 @default.
• W4313584079 cites W3045120467 @default.
• W4313584079 cites W3124473610 @default.
• W4313584079 cites W3126810552 @default.
• W4313584079 cites W3128800281 @default.
• W4313584079 cites W4205936314 @default.
• W4313584079 cites W4210994334 @default.
• W4313584079 cites W4247747154 @default.
• W4313584079 doi "https://doi.org/10.3390/ijms24020933" @default.
• W4313584079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36674444" @default.
• W4313584079 hasPublicationYear "2023" @default.
• W4313584079 type Work @default.
• W4313584079 citedByCount "1" @default.
• W4313584079 countsByYear W43135840792023 @default.
• W4313584079 crossrefType "journal-article" @default.
• W4313584079 hasAuthorship W4313584079A5023661274 @default.
• W4313584079 hasAuthorship W4313584079A5029663970 @default.
• W4313584079 hasAuthorship W4313584079A5043473548 @default.
• W4313584079 hasAuthorship W4313584079A5049141535 @default.
• W4313584079 hasAuthorship W4313584079A5067261920 @default.
• W4313584079 hasAuthorship W4313584079A5080367407 @default.
• W4313584079 hasAuthorship W4313584079A5085137039 @default.
• W4313584079 hasAuthorship W4313584079A5085440633 @default.
• W4313584079 hasAuthorship W4313584079A5085786569 @default.
• W4313584079 hasBestOaLocation W43135840791 @default.
• W4313584079 hasConcept C126322002 @default.
• W4313584079 hasConcept C134018914 @default.
• W4313584079 hasConcept C2777977426 @default.
• W4313584079 hasConcept C2778163477 @default.
• W4313584079 hasConcept C2778736161 @default.
• W4313584079 hasConcept C2780352252 @default.
• W4313584079 hasConcept C2780694816 @default.
• W4313584079 hasConcept C49039625 @default.
• W4313584079 hasConcept C71315377 @default.
• W4313584079 hasConcept C71924100 @default.
• W4313584079 hasConcept C86803240 @default.
• W4313584079 hasConceptScore W4313584079C126322002 @default.
• W4313584079 hasConceptScore W4313584079C134018914 @default.
• W4313584079 hasConceptScore W4313584079C2777977426 @default.
• W4313584079 hasConceptScore W4313584079C2778163477 @default.
• W4313584079 hasConceptScore W4313584079C2778736161 @default.
• W4313584079 hasConceptScore W4313584079C2780352252 @default.
• W4313584079 hasConceptScore W4313584079C2780694816 @default.
• W4313584079 hasConceptScore W4313584079C49039625 @default.
• W4313584079 hasConceptScore W4313584079C71315377 @default.
• W4313584079 hasConceptScore W4313584079C71924100 @default.
• W4313584079 hasConceptScore W4313584079C86803240 @default.
• W4313584079 hasIssue "2" @default.
• W4313584079 hasLocation W43135840791 @default.
• W4313584079 hasLocation W43135840792 @default.
• W4313584079 hasLocation W43135840793 @default.
• W4313584079 hasOpenAccess W4313584079 @default.

• next