Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313584525> ?p ?o ?g. }
- W4313584525 abstract "Introduction: Venlafaxine is one of the most commonly used anti-depressant and antineoplastic drug. Previous studies have predicted venlafaxine as an anti-cancer compound, but the therapeutic effects of venlafaxine in melanoma have not yet been demonstrated. Nur77 is an orphan nuclear receptor that highly expressed in melanoma cells and can interact with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic protein. Method: We examined the effects of venlafaxine in MV3 cells in vitro and MV3 xenograft tumor in nude mice. Western-blot, PCR, TUNEL assay and immunofluorescence were used to reveal the growth of melanoma cells. Results: Here, our data revealed that venlafaxine could reduce the growth, and induce apoptosis of melanoma cells through a Nur77-dependent way. Our results also showed that treatment with venlafaxine (20 mg/kg, i.p.) potently inhibited the growth of melanoma cells in nude mice. Mechanistically, venlafaxine activated JNK1/2 signaling, induced Nur77 expressions and mitochondrial localization, thereby promoting apoptosis of melanoma cells. Knockdown of Nur77 and JNK1/2, or inhibition of JNK1/2 signaling with its inhibitor SP600125 attenuated the anti-cancer effects of venlafaxine. Conclusion: In summary, our results suggested venlafaxine as a potential therapy for melanoma." @default.
- W4313584525 created "2023-01-06" @default.
- W4313584525 creator A5018866860 @default.
- W4313584525 creator A5026905317 @default.
- W4313584525 creator A5034616532 @default.
- W4313584525 creator A5053737183 @default.
- W4313584525 creator A5069802652 @default.
- W4313584525 creator A5070778210 @default.
- W4313584525 creator A5077666079 @default.
- W4313584525 date "2023-01-04" @default.
- W4313584525 modified "2023-09-27" @default.
- W4313584525 title "Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway" @default.
- W4313584525 cites W1898702228 @default.
- W4313584525 cites W1965225612 @default.
- W4313584525 cites W1978580089 @default.
- W4313584525 cites W1994785159 @default.
- W4313584525 cites W2021973620 @default.
- W4313584525 cites W2021979251 @default.
- W4313584525 cites W2033161660 @default.
- W4313584525 cites W2067343408 @default.
- W4313584525 cites W2078822172 @default.
- W4313584525 cites W2095466199 @default.
- W4313584525 cites W2102185138 @default.
- W4313584525 cites W2108804546 @default.
- W4313584525 cites W2123715909 @default.
- W4313584525 cites W2135919935 @default.
- W4313584525 cites W2153940938 @default.
- W4313584525 cites W2155235678 @default.
- W4313584525 cites W2399987572 @default.
- W4313584525 cites W2604143793 @default.
- W4313584525 cites W2736058010 @default.
- W4313584525 cites W2787217481 @default.
- W4313584525 cites W2793987554 @default.
- W4313584525 cites W2797956345 @default.
- W4313584525 cites W2888950310 @default.
- W4313584525 cites W2893404020 @default.
- W4313584525 cites W2900211185 @default.
- W4313584525 cites W2926463281 @default.
- W4313584525 cites W2932310957 @default.
- W4313584525 cites W2945360501 @default.
- W4313584525 cites W2987691085 @default.
- W4313584525 cites W3009047251 @default.
- W4313584525 cites W3009963727 @default.
- W4313584525 cites W3023743671 @default.
- W4313584525 cites W3033593903 @default.
- W4313584525 cites W3033841343 @default.
- W4313584525 cites W3044659637 @default.
- W4313584525 cites W3093909108 @default.
- W4313584525 cites W3126779411 @default.
- W4313584525 cites W3193836708 @default.
- W4313584525 cites W3201412466 @default.
- W4313584525 cites W3207168347 @default.
- W4313584525 cites W3216879828 @default.
- W4313584525 cites W4200013035 @default.
- W4313584525 cites W4200168827 @default.
- W4313584525 cites W4205710174 @default.
- W4313584525 cites W4205925743 @default.
- W4313584525 cites W4210243667 @default.
- W4313584525 cites W4210854533 @default.
- W4313584525 cites W4224278124 @default.
- W4313584525 cites W4280541187 @default.
- W4313584525 cites W4283275343 @default.
- W4313584525 cites W4294668778 @default.
- W4313584525 cites W4296817123 @default.
- W4313584525 cites W4297541838 @default.
- W4313584525 cites W4308148180 @default.
- W4313584525 cites W4309797616 @default.
- W4313584525 cites W3164735464 @default.
- W4313584525 doi "https://doi.org/10.3389/fphar.2022.1080412" @default.
- W4313584525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36686679" @default.
- W4313584525 hasPublicationYear "2023" @default.
- W4313584525 type Work @default.
- W4313584525 citedByCount "0" @default.
- W4313584525 crossrefType "journal-article" @default.
- W4313584525 hasAuthorship W4313584525A5018866860 @default.
- W4313584525 hasAuthorship W4313584525A5026905317 @default.
- W4313584525 hasAuthorship W4313584525A5034616532 @default.
- W4313584525 hasAuthorship W4313584525A5053737183 @default.
- W4313584525 hasAuthorship W4313584525A5069802652 @default.
- W4313584525 hasAuthorship W4313584525A5070778210 @default.
- W4313584525 hasAuthorship W4313584525A5077666079 @default.
- W4313584525 hasBestOaLocation W43135845251 @default.
- W4313584525 hasConcept C104317684 @default.
- W4313584525 hasConcept C134018914 @default.
- W4313584525 hasConcept C185592680 @default.
- W4313584525 hasConcept C190283241 @default.
- W4313584525 hasConcept C2776466888 @default.
- W4313584525 hasConcept C2777658100 @default.
- W4313584525 hasConcept C2779177272 @default.
- W4313584525 hasConcept C2781161787 @default.
- W4313584525 hasConcept C35552991 @default.
- W4313584525 hasConcept C502942594 @default.
- W4313584525 hasConcept C55493867 @default.
- W4313584525 hasConcept C63932345 @default.
- W4313584525 hasConcept C71924100 @default.
- W4313584525 hasConcept C86339819 @default.
- W4313584525 hasConcept C98274493 @default.
- W4313584525 hasConceptScore W4313584525C104317684 @default.
- W4313584525 hasConceptScore W4313584525C134018914 @default.
- W4313584525 hasConceptScore W4313584525C185592680 @default.