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• W4313584551 abstract "Providencia rettgeri has recently gained increased importance owing to the New Delhi metallo-β-lactamase (NDM) and other β-lactamases produced by its clinical isolates. These enzymes reduce the efficiency of antimicrobial therapy. Herein, we reported the findings of whole-genome sequence analysis and a comprehensive pan-genome analysis performed on a multidrug-resistant P . rettgeri 18004577 clinical strain recovered from the urine of a hospitalized patient in Shandong, China, in 2018. Providencia rettgeri 18004577 was found to have a genome assembly size of 4.6 Mb with a G + C content of 41%; a circular plasmid p18004577_NDM of 273.3 Kb, harboring an accessory multidrug-resistant region; and a circular, stable IncT plasmid p18004577_Rts of 146.2 Kb. Additionally, various resistance genes were identified in its genome, including bla NDM-1 , bla OXA-10 , bla PER-4 , aph ( 3′ ) -VI , ant ( 2′′ ) -Ia , ant ( 3′ ) -Ia , sul1 , catB8 , catA1 , mph ( E ), and tet . Conjugation experiments and whole-genome sequencing revealed that the bla NDM-1 gene could be transferred to the transconjugant via the formation of pJ18004577_NDM, a novel hybrid plasmid. Based on the genetic comparison, the main possible formation process for pJ18004577_ NDM was the insertion of the [ ΔISKox2-IS26-ΔISKox2 ] -aph ( 3′ ) -VI-bla NDM-1 translocatable unit module from p18004577_ NDM into plasmid p18004577_Rts in the Russian doll insertion structure ( ΔISKox2-IS26-ΔISKox2 ), which played a role similar to that of IS26 using the “copy-in” route in the mobilization of [ aph ( 3′ ) -VI ] -bla NDM-1 . The array, multiplicity, and diversity of the resistance and virulence genes in this strain necessitate stringent infection control, antibiotic stewardship, and periodic resistance surveillance/monitoring policies to preempt further horizontal and vertical spread of the resistance genes. Roary analysis based on 30 P . rettgeri strains pan genome identified 415 core, 756 soft core, 5,744 shell, and 12,967 cloud genes, highlighting the “close” nature of P . rettgeri pan-genome. After a comprehensive pan-genome analysis, representative biological information was revealed that included phylogenetic distances, presence or absence of genes across the P . rettgeri bacteria clade, and functional distribution of proteins. Moreover, pan-genome analysis has been shown to be an effective approach to better understand P . rettgeri bacteria because it helps develop various tailored therapeutic strategies based on their biological similarities and differences." @default.
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• W4313584551 date "2023-01-04" @default.
• W4313584551 modified "2023-10-01" @default.
• W4313584551 title "Conjugation of plasmid harboring blaNDM-1 in a clinical Providencia rettgeri strain through the formation of a fusion plasmid" @default.
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• W4313584551 doi "https://doi.org/10.3389/fmicb.2022.1071385" @default.
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