FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313584747> ?p ?o ?g. }

• W4313584747 abstract "Background: Petite Integration Factor 1 (PIF1) is a multifunctional helicase and DNA processing enzyme that plays an important role in the process of several cancer types. However, the relationship between clear cell renal cell carcinoma (ccRCC) and PIF1 remains unclear. This study aims to explore the role of PIF1 in ccRCC tumorigenesis and prognosis. Methods: Based on The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database, we retrieved and verified the expression of PIF1 in ccRCC tissues as well as normal tissues. To assess the protein expression of PIF1 by using the Human Protein Atlas and the Clinical Proteomic Tumor Analysis Consortium (CPTAC). We also performed receiver operating characteristic (ROC) curve analysis to differentiate the effectiveness of PIF1 in ccRCC and adjacent normal tissues. To evaluate the value of PIF1 on clinical outcomes in ccRCC patients by using multivariate methods and Kaplan‒Meier survival curves. Protein‒protein interaction (PPI) networks were made with STRING. We determined the relationship between the expression of PIF1 and immune cell infiltration with single-sample gene set enrichment analysis (ssGSEA). Results: Compared with normal tissues, the expression of PIF1 was significantly elevated in ccRCC. The mRNA expression of PIF1 is correlated with high TNM stage and high pathologic stage. The receiver operating characteristic (ROC) curve analysis showed that PIF1 was related to an area under the curve (AUC) value of 0.928 to distinguish between ccRCC tissues and normal tissues. Kaplan‒Meier survival analysis showed that the overall survival (OS) of ccRCC patients with a high level of PIF1 was significantly shorter than that of those with a low level of PIF1. PIF1 may play an important role in the occurrence of tumors. Correlation analysis showed that PIF1-mediated carcinogenesis may participate in the process of tumor immune escape in ccRCC. Conclusion: PIF1 could be a reference biomarker to identify ccRCC patients with poor prognosis. PIF1 may play a distinct role in the microenvironment of ccRCC by regulating tumor infiltration of immune cells, which is a new therapeutic target to affect the growth of the tumor." @default.
• W4313584747 created "2023-01-06" @default.
• W4313584747 creator A5043354088 @default.
• W4313584747 creator A5043420288 @default.
• W4313584747 creator A5043839950 @default.
• W4313584747 creator A5061642965 @default.
• W4313584747 creator A5083890892 @default.
• W4313584747 date "2023-01-04" @default.
• W4313584747 modified "2023-10-14" @default.
• W4313584747 title "Up-regulated PIF1 predicts poor clinical outcomes and correlates with low immune infiltrates in clear cell renal cell carcinoma" @default.
• W4313584747 cites W1757407923 @default.
• W4313584747 cites W1910696387 @default.
• W4313584747 cites W1965087303 @default.
• W4313584747 cites W1966744160 @default.
• W4313584747 cites W1968493165 @default.
• W4313584747 cites W1977305809 @default.
• W4313584747 cites W1984276429 @default.
• W4313584747 cites W1989170090 @default.
• W4313584747 cites W1991365889 @default.
• W4313584747 cites W1999472367 @default.
• W4313584747 cites W2004099247 @default.
• W4313584747 cites W2006220727 @default.
• W4313584747 cites W2016177359 @default.
• W4313584747 cites W2020262431 @default.
• W4313584747 cites W2035170656 @default.
• W4313584747 cites W2077605689 @default.
• W4313584747 cites W2085557285 @default.
• W4313584747 cites W2100310707 @default.
• W4313584747 cites W2121371748 @default.
• W4313584747 cites W2133051107 @default.
• W4313584747 cites W2155001149 @default.
• W4313584747 cites W2158737337 @default.
• W4313584747 cites W2160336344 @default.
• W4313584747 cites W2160918055 @default.
• W4313584747 cites W2164317031 @default.
• W4313584747 cites W2340994994 @default.
• W4313584747 cites W2409657626 @default.
• W4313584747 cites W2578528809 @default.
• W4313584747 cites W2614480329 @default.
• W4313584747 cites W2796207353 @default.
• W4313584747 cites W2914556220 @default.
• W4313584747 cites W2919983752 @default.
• W4313584747 cites W2949791825 @default.
• W4313584747 cites W2952167957 @default.
• W4313584747 cites W3080153596 @default.
• W4313584747 cites W3203915612 @default.
• W4313584747 cites W4294358748 @default.
• W4313584747 doi "https://doi.org/10.3389/fgene.2022.1058040" @default.
• W4313584747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685888" @default.
• W4313584747 hasPublicationYear "2023" @default.
• W4313584747 type Work @default.
• W4313584747 citedByCount "1" @default.
• W4313584747 countsByYear W43135847472023 @default.
• W4313584747 crossrefType "journal-article" @default.
• W4313584747 hasAuthorship W4313584747A5043354088 @default.
• W4313584747 hasAuthorship W4313584747A5043420288 @default.
• W4313584747 hasAuthorship W4313584747A5043839950 @default.
• W4313584747 hasAuthorship W4313584747A5061642965 @default.
• W4313584747 hasAuthorship W4313584747A5083890892 @default.
• W4313584747 hasBestOaLocation W43135847471 @default.
• W4313584747 hasConcept C104317684 @default.
• W4313584747 hasConcept C10515644 @default.
• W4313584747 hasConcept C121608353 @default.
• W4313584747 hasConcept C126322002 @default.
• W4313584747 hasConcept C143998085 @default.
• W4313584747 hasConcept C146357865 @default.
• W4313584747 hasConcept C1491633281 @default.
• W4313584747 hasConcept C151730666 @default.
• W4313584747 hasConcept C158163496 @default.
• W4313584747 hasConcept C2777472916 @default.
• W4313584747 hasConcept C2781278892 @default.
• W4313584747 hasConcept C502942594 @default.
• W4313584747 hasConcept C54355233 @default.
• W4313584747 hasConcept C555283112 @default.
• W4313584747 hasConcept C58471807 @default.
• W4313584747 hasConcept C6856738 @default.
• W4313584747 hasConcept C71924100 @default.
• W4313584747 hasConcept C86803240 @default.
• W4313584747 hasConceptScore W4313584747C104317684 @default.
• W4313584747 hasConceptScore W4313584747C10515644 @default.
• W4313584747 hasConceptScore W4313584747C121608353 @default.
• W4313584747 hasConceptScore W4313584747C126322002 @default.
• W4313584747 hasConceptScore W4313584747C143998085 @default.
• W4313584747 hasConceptScore W4313584747C146357865 @default.
• W4313584747 hasConceptScore W4313584747C1491633281 @default.
• W4313584747 hasConceptScore W4313584747C151730666 @default.
• W4313584747 hasConceptScore W4313584747C158163496 @default.
• W4313584747 hasConceptScore W4313584747C2777472916 @default.
• W4313584747 hasConceptScore W4313584747C2781278892 @default.
• W4313584747 hasConceptScore W4313584747C502942594 @default.
• W4313584747 hasConceptScore W4313584747C54355233 @default.
• W4313584747 hasConceptScore W4313584747C555283112 @default.
• W4313584747 hasConceptScore W4313584747C58471807 @default.
• W4313584747 hasConceptScore W4313584747C6856738 @default.
• W4313584747 hasConceptScore W4313584747C71924100 @default.
• W4313584747 hasConceptScore W4313584747C86803240 @default.
• W4313584747 hasLocation W43135847471 @default.
• W4313584747 hasLocation W43135847472 @default.
• W4313584747 hasLocation W43135847473 @default.
• W4313584747 hasOpenAccess W4313584747 @default.

• next