Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313584766> ?p ?o ?g. }
- W4313584766 endingPage "445" @default.
- W4313584766 startingPage "445" @default.
- W4313584766 abstract "Cannabidiol (CBD) from Cannabis sativa is used in cosmetics in North America due to its antibacterial and antioxidant properties, but has been prohibited in many countries except recently; so, finding a non-intoxicating CBD alternative and elucidating the structure–function relationship of CBD analogues is becoming increasingly relevant. Herein, a set of CBD analogues including 8,9-dihydrocannabidiol (H2CBD) was synthesized, and their antibacterial, bactericidal, and antioxidant activity, as well as their structure–function relationship, were studied. The results present a catalytic selectivity near 100% towards H2CBD with a production yield of 85%. Each CBD analogue presented different antibacterial and antioxidant activity. It is revealed that the phenolic hydroxyl moiety is an essential group for CBD analogues to perform antibacterial and antioxidant activities. Among them, H2CBD presented much stronger antibacterial activity than the assayed popular antibiotics. H2CBD and Compound 4 presented very similar radical scavenging activity and inhibition on lipid oxidation to vitamin C, but better thermostability. Moreover, H2CBD presented lower toxicity to human skin fibroblasts at concentrations up to 64-fold higher than its MIC value (1.25 μg/mL) against S. aureus. Above all, in all property experiments, H2CBD presented extremely similar performance to CBD (p < 0.05), including similar time–kill kinetics curves. This research finds H2CBD to be an alternative for CBD with very high potential in the aspects of antibacterial, bactericidal, and antioxidant activity, as well as lower toxicity to human skin fibroblasts." @default.
- W4313584766 created "2023-01-06" @default.
- W4313584766 creator A5017800332 @default.
- W4313584766 creator A5023702304 @default.
- W4313584766 creator A5062566198 @default.
- W4313584766 creator A5064666806 @default.
- W4313584766 creator A5079794110 @default.
- W4313584766 date "2023-01-03" @default.
- W4313584766 modified "2023-10-11" @default.
- W4313584766 title "8,9-Dihydrocannabidiol, an Alternative of Cannabidiol, Its Preparation, Antibacterial and Antioxidant Ability" @default.
- W4313584766 cites W1530296897 @default.
- W4313584766 cites W1941707323 @default.
- W4313584766 cites W1963709167 @default.
- W4313584766 cites W1966757486 @default.
- W4313584766 cites W1986671176 @default.
- W4313584766 cites W2040998189 @default.
- W4313584766 cites W2095350647 @default.
- W4313584766 cites W2114062911 @default.
- W4313584766 cites W2162405876 @default.
- W4313584766 cites W2165292984 @default.
- W4313584766 cites W2405977038 @default.
- W4313584766 cites W2593686382 @default.
- W4313584766 cites W2693016255 @default.
- W4313584766 cites W2944271715 @default.
- W4313584766 cites W2944770517 @default.
- W4313584766 cites W2953759557 @default.
- W4313584766 cites W2970129212 @default.
- W4313584766 cites W2998014803 @default.
- W4313584766 cites W3006624590 @default.
- W4313584766 cites W3009698941 @default.
- W4313584766 cites W3035513805 @default.
- W4313584766 cites W3085802627 @default.
- W4313584766 cites W3089713264 @default.
- W4313584766 cites W3092116360 @default.
- W4313584766 cites W3097067210 @default.
- W4313584766 cites W3111911269 @default.
- W4313584766 cites W3114876437 @default.
- W4313584766 cites W3124203334 @default.
- W4313584766 cites W3127918076 @default.
- W4313584766 cites W3134168081 @default.
- W4313584766 cites W3134268574 @default.
- W4313584766 cites W3135169005 @default.
- W4313584766 cites W3143124482 @default.
- W4313584766 cites W3156483946 @default.
- W4313584766 cites W3157775792 @default.
- W4313584766 cites W3177171375 @default.
- W4313584766 cites W4206476852 @default.
- W4313584766 cites W4224252364 @default.
- W4313584766 cites W4281260423 @default.
- W4313584766 cites W4296006128 @default.
- W4313584766 doi "https://doi.org/10.3390/molecules28010445" @default.
- W4313584766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36615636" @default.
- W4313584766 hasPublicationYear "2023" @default.
- W4313584766 type Work @default.
- W4313584766 citedByCount "6" @default.
- W4313584766 countsByYear W43135847662023 @default.
- W4313584766 crossrefType "journal-article" @default.
- W4313584766 hasAuthorship W4313584766A5017800332 @default.
- W4313584766 hasAuthorship W4313584766A5023702304 @default.
- W4313584766 hasAuthorship W4313584766A5062566198 @default.
- W4313584766 hasAuthorship W4313584766A5064666806 @default.
- W4313584766 hasAuthorship W4313584766A5079794110 @default.
- W4313584766 hasBestOaLocation W43135847661 @default.
- W4313584766 hasConcept C118552586 @default.
- W4313584766 hasConcept C150903083 @default.
- W4313584766 hasConcept C185592680 @default.
- W4313584766 hasConcept C2776895053 @default.
- W4313584766 hasConcept C2777056318 @default.
- W4313584766 hasConcept C2778004101 @default.
- W4313584766 hasConcept C2780104969 @default.
- W4313584766 hasConcept C2780532717 @default.
- W4313584766 hasConcept C523546767 @default.
- W4313584766 hasConcept C54355233 @default.
- W4313584766 hasConcept C55493867 @default.
- W4313584766 hasConcept C71924100 @default.
- W4313584766 hasConcept C86803240 @default.
- W4313584766 hasConceptScore W4313584766C118552586 @default.
- W4313584766 hasConceptScore W4313584766C150903083 @default.
- W4313584766 hasConceptScore W4313584766C185592680 @default.
- W4313584766 hasConceptScore W4313584766C2776895053 @default.
- W4313584766 hasConceptScore W4313584766C2777056318 @default.
- W4313584766 hasConceptScore W4313584766C2778004101 @default.
- W4313584766 hasConceptScore W4313584766C2780104969 @default.
- W4313584766 hasConceptScore W4313584766C2780532717 @default.
- W4313584766 hasConceptScore W4313584766C523546767 @default.
- W4313584766 hasConceptScore W4313584766C54355233 @default.
- W4313584766 hasConceptScore W4313584766C55493867 @default.
- W4313584766 hasConceptScore W4313584766C71924100 @default.
- W4313584766 hasConceptScore W4313584766C86803240 @default.
- W4313584766 hasFunder F4320321001 @default.
- W4313584766 hasIssue "1" @default.
- W4313584766 hasLocation W43135847661 @default.
- W4313584766 hasLocation W43135847662 @default.
- W4313584766 hasLocation W43135847663 @default.
- W4313584766 hasOpenAccess W4313584766 @default.
- W4313584766 hasPrimaryLocation W43135847661 @default.
- W4313584766 hasRelatedWork W1906062429 @default.
- W4313584766 hasRelatedWork W2049577874 @default.