FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313584809> ?p ?o ?g. }

• W4313584809 endingPage "839" @default.
• W4313584809 startingPage "839" @default.
• W4313584809 abstract "Chondrosarcoma is the second most common type of bone cancer. Surgical resection is the best choice for clinical treatment. High-grade chondrosarcoma is destructive and is more possible to metastasis, which is difficult to remove using surgery. Doxorubicin (Dox) is the most commonly used chemotherapy drug in the clinical setting; however, drug resistance is a major obstacle to effective treatment. In the present study, we compared Dox-resistant SW1353 cells to their parental cells using RNA sequencing (RNA-Seq). We found that the apelin (APLN) pathway was highly activated in resistant cells. In addition, tissue array analysis also showed that APLN was higher in high-grade tissues compared to low-grade tissues. APLN is a member of the adipokine family, which is a novel secreted peptide with multifunctional and biological activities. Previously, studies have shown that inhibition of the APLN axis may have a therapeutic benefit in cancers. However, the role of APLN in chondrosarcoma is completely unclear, and no related studies have been reported. During in vitro experiments, APLN was also observed to be highly expressed and secreted in Dox-resistant cells. Once APLN was knocked down, it could effectively improve its sensitivity to Dox. We also explored possible upstream regulatory microRNAs (miRNAs) of APLN through bioinformatics tools and the results disclosed that miR-631 was the most likely regulator of APLN. Furthermore, the expression of miR-631 was lower in the resistant cells, but overexpression of miR-631 in the Dox-resistant cell lines significantly increased the Dox sensitivity. These results were also observed in another chondrosarcoma cell line, JJ012 cells. Taken together, these findings will provide rationale for the development of drug resistance biomarkers and therapeutic strategies for APLN pathway inhibitors to improve the survival of patients with chondrosarcoma." @default.
• W4313584809 created "2023-01-06" @default.
• W4313584809 creator A5002915176 @default.
• W4313584809 creator A5026337340 @default.
• W4313584809 creator A5030949828 @default.
• W4313584809 creator A5047079076 @default.
• W4313584809 creator A5076096342 @default.
• W4313584809 creator A5079022979 @default.
• W4313584809 creator A5080760900 @default.
• W4313584809 creator A5081629472 @default.
• W4313584809 date "2023-01-03" @default.
• W4313584809 modified "2023-09-26" @default.
• W4313584809 title "MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin" @default.
• W4313584809 cites W1481822065 @default.
• W4313584809 cites W1648301895 @default.
• W4313584809 cites W1978260566 @default.
• W4313584809 cites W1999025555 @default.
• W4313584809 cites W2017777108 @default.
• W4313584809 cites W2018991117 @default.
• W4313584809 cites W2028273450 @default.
• W4313584809 cites W2037513882 @default.
• W4313584809 cites W2048085798 @default.
• W4313584809 cites W2050394253 @default.
• W4313584809 cites W2055624262 @default.
• W4313584809 cites W2058135511 @default.
• W4313584809 cites W2060660919 @default.
• W4313584809 cites W2063865968 @default.
• W4313584809 cites W2064295299 @default.
• W4313584809 cites W2075714512 @default.
• W4313584809 cites W2079088649 @default.
• W4313584809 cites W2080551186 @default.
• W4313584809 cites W2083381199 @default.
• W4313584809 cites W2087867260 @default.
• W4313584809 cites W2100243692 @default.
• W4313584809 cites W2102897174 @default.
• W4313584809 cites W2102950426 @default.
• W4313584809 cites W2109120098 @default.
• W4313584809 cites W2110792972 @default.
• W4313584809 cites W2117391818 @default.
• W4313584809 cites W2140182328 @default.
• W4313584809 cites W2150312029 @default.
• W4313584809 cites W2151832198 @default.
• W4313584809 cites W2159252822 @default.
• W4313584809 cites W2163577941 @default.
• W4313584809 cites W2463843208 @default.
• W4313584809 cites W2530539774 @default.
• W4313584809 cites W2552471888 @default.
• W4313584809 cites W2591863096 @default.
• W4313584809 cites W2606328160 @default.
• W4313584809 cites W2618873270 @default.
• W4313584809 cites W2744762533 @default.
• W4313584809 cites W2767185614 @default.
• W4313584809 cites W2802924594 @default.
• W4313584809 cites W2805669297 @default.
• W4313584809 cites W2897500321 @default.
• W4313584809 cites W2908713273 @default.
• W4313584809 cites W2909017711 @default.
• W4313584809 cites W2920852015 @default.
• W4313584809 cites W2937718212 @default.
• W4313584809 cites W2944145978 @default.
• W4313584809 cites W2944216054 @default.
• W4313584809 cites W3006682034 @default.
• W4313584809 cites W3008043126 @default.
• W4313584809 cites W3155496868 @default.
• W4313584809 cites W3166812294 @default.
• W4313584809 cites W4220659440 @default.
• W4313584809 cites W4296916383 @default.
• W4313584809 doi "https://doi.org/10.3390/ijms24010839" @default.
• W4313584809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36614283" @default.
• W4313584809 hasPublicationYear "2023" @default.
• W4313584809 type Work @default.
• W4313584809 citedByCount "2" @default.
• W4313584809 countsByYear W43135848092023 @default.
• W4313584809 crossrefType "journal-article" @default.
• W4313584809 hasAuthorship W4313584809A5002915176 @default.
• W4313584809 hasAuthorship W4313584809A5026337340 @default.
• W4313584809 hasAuthorship W4313584809A5030949828 @default.
• W4313584809 hasAuthorship W4313584809A5047079076 @default.
• W4313584809 hasAuthorship W4313584809A5076096342 @default.
• W4313584809 hasAuthorship W4313584809A5079022979 @default.
• W4313584809 hasAuthorship W4313584809A5080760900 @default.
• W4313584809 hasAuthorship W4313584809A5081629472 @default.
• W4313584809 hasBestOaLocation W43135848091 @default.
• W4313584809 hasConcept C104317684 @default.
• W4313584809 hasConcept C114851261 @default.
• W4313584809 hasConcept C126322002 @default.
• W4313584809 hasConcept C137620995 @default.
• W4313584809 hasConcept C142724271 @default.
• W4313584809 hasConcept C145059251 @default.
• W4313584809 hasConcept C170493617 @default.
• W4313584809 hasConcept C2776302905 @default.
• W4313584809 hasConcept C2776694085 @default.
• W4313584809 hasConcept C2779546753 @default.
• W4313584809 hasConcept C2781303535 @default.
• W4313584809 hasConcept C502942594 @default.
• W4313584809 hasConcept C54355233 @default.
• W4313584809 hasConcept C60644358 @default.
• W4313584809 hasConcept C71924100 @default.

• next