FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313585227> ?p ?o ?g. }

• W4313585227 abstract "The serum level of cholesterol and its biosynthetic intermediates are critical indicators to access metabolism-related disorders in humans and animals. However, the molecular actions of these intermediates on gene functions and regulation remained elusive. Here, we show that desmosterol (DES) is the most abundant intermediate involved in cholesterol biosynthesis and is highly enriched in red/brown algae. It exerts a pivotal role in modulating core genes involved in oxidative stress and inflammatory response processes in the ileum epithelial cells (IPI-2I). We observed that the DES extracted from red algae did not affect IPI-2I cell growth or survival. A transcriptomic measurement revealed that the genes enrolled in the oxidative process and cholesterol homeostasis pathway were significantly down-regulated by DES treatment. Consistent with this notion, cellular reactive oxygen species (ROS) levels were markedly decreased in response to DES treatment. In contrast, key inflammatory genes including IL-6 , TNF-α , and IFN-γ were remarkably upregulated in the RNA-seq analysis, as further confirmed by qRT-PCR. Given that DES is a specific agonist of nuclear receptor RORγ, we also found that DES caused the elevated expression of RORγ at mRNA and protein levels, suggesting it is a potential mediator under DES administration. Together, these results underscore the vital physiological actions of DES in inflammatory and oxidative processes possibly via RORγ, and may be helpful in anti-oxidation treatment and immunotherapy in the future." @default.
• W4313585227 created "2023-01-06" @default.
• W4313585227 creator A5011012416 @default.
• W4313585227 creator A5019693172 @default.
• W4313585227 creator A5035391673 @default.
• W4313585227 creator A5037274043 @default.
• W4313585227 creator A5039621489 @default.
• W4313585227 creator A5058466469 @default.
• W4313585227 creator A5076376944 @default.
• W4313585227 creator A5079286251 @default.
• W4313585227 creator A5079623442 @default.
• W4313585227 date "2023-01-04" @default.
• W4313585227 modified "2023-09-30" @default.
• W4313585227 title "Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells" @default.
• W4313585227 cites W1947355021 @default.
• W4313585227 cites W1979189704 @default.
• W4313585227 cites W1996228271 @default.
• W4313585227 cites W2011868525 @default.
• W4313585227 cites W2018002734 @default.
• W4313585227 cites W2021154596 @default.
• W4313585227 cites W2033883349 @default.
• W4313585227 cites W2049169935 @default.
• W4313585227 cites W2067226772 @default.
• W4313585227 cites W2084183927 @default.
• W4313585227 cites W2125786873 @default.
• W4313585227 cites W2160681814 @default.
• W4313585227 cites W2283906695 @default.
• W4313585227 cites W2409057459 @default.
• W4313585227 cites W2549049593 @default.
• W4313585227 cites W2934151230 @default.
• W4313585227 cites W2941241726 @default.
• W4313585227 cites W2951609462 @default.
• W4313585227 cites W2980147314 @default.
• W4313585227 cites W3004526380 @default.
• W4313585227 cites W3012377065 @default.
• W4313585227 cites W3163296545 @default.
• W4313585227 cites W3186966241 @default.
• W4313585227 cites W3193797930 @default.
• W4313585227 cites W3211901466 @default.
• W4313585227 cites W3213215676 @default.
• W4313585227 cites W3217324349 @default.
• W4313585227 cites W4200050535 @default.
• W4313585227 cites W4213317022 @default.
• W4313585227 cites W4285732123 @default.
• W4313585227 cites W4303579144 @default.
• W4313585227 doi "https://doi.org/10.3389/fimmu.2022.1101643" @default.
• W4313585227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685553" @default.
• W4313585227 hasPublicationYear "2023" @default.
• W4313585227 type Work @default.
• W4313585227 citedByCount "0" @default.
• W4313585227 crossrefType "journal-article" @default.
• W4313585227 hasAuthorship W4313585227A5011012416 @default.
• W4313585227 hasAuthorship W4313585227A5019693172 @default.
• W4313585227 hasAuthorship W4313585227A5035391673 @default.
• W4313585227 hasAuthorship W4313585227A5037274043 @default.
• W4313585227 hasAuthorship W4313585227A5039621489 @default.
• W4313585227 hasAuthorship W4313585227A5058466469 @default.
• W4313585227 hasAuthorship W4313585227A5076376944 @default.
• W4313585227 hasAuthorship W4313585227A5079286251 @default.
• W4313585227 hasAuthorship W4313585227A5079623442 @default.
• W4313585227 hasBestOaLocation W43135852271 @default.
• W4313585227 hasConcept C104317684 @default.
• W4313585227 hasConcept C150194340 @default.
• W4313585227 hasConcept C162317418 @default.
• W4313585227 hasConcept C167400880 @default.
• W4313585227 hasConcept C185592680 @default.
• W4313585227 hasConcept C203014093 @default.
• W4313585227 hasConcept C2776151105 @default.
• W4313585227 hasConcept C2776914184 @default.
• W4313585227 hasConcept C48349386 @default.
• W4313585227 hasConcept C55493867 @default.
• W4313585227 hasConcept C57600042 @default.
• W4313585227 hasConcept C63932345 @default.
• W4313585227 hasConcept C86339819 @default.
• W4313585227 hasConcept C86803240 @default.
• W4313585227 hasConcept C95444343 @default.
• W4313585227 hasConceptScore W4313585227C104317684 @default.
• W4313585227 hasConceptScore W4313585227C150194340 @default.
• W4313585227 hasConceptScore W4313585227C162317418 @default.
• W4313585227 hasConceptScore W4313585227C167400880 @default.
• W4313585227 hasConceptScore W4313585227C185592680 @default.
• W4313585227 hasConceptScore W4313585227C203014093 @default.
• W4313585227 hasConceptScore W4313585227C2776151105 @default.
• W4313585227 hasConceptScore W4313585227C2776914184 @default.
• W4313585227 hasConceptScore W4313585227C48349386 @default.
• W4313585227 hasConceptScore W4313585227C55493867 @default.
• W4313585227 hasConceptScore W4313585227C57600042 @default.
• W4313585227 hasConceptScore W4313585227C63932345 @default.
• W4313585227 hasConceptScore W4313585227C86339819 @default.
• W4313585227 hasConceptScore W4313585227C86803240 @default.
• W4313585227 hasConceptScore W4313585227C95444343 @default.
• W4313585227 hasFunder F4320321001 @default.
• W4313585227 hasFunder F4320322769 @default.
• W4313585227 hasLocation W43135852271 @default.
• W4313585227 hasLocation W43135852272 @default.
• W4313585227 hasLocation W43135852273 @default.
• W4313585227 hasOpenAccess W4313585227 @default.
• W4313585227 hasPrimaryLocation W43135852271 @default.
• W4313585227 hasRelatedWork W1990840232 @default.
• W4313585227 hasRelatedWork W1994113916 @default.

• next