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• W4313585546 abstract "The concept of dedifferentiation and reprogramming of mature somatic cells holds much promise for the three-front war against tissue damage, cancer, and aging. It was hoped that reprogramming human somatic cells into the induced pluripotent state, along with the use of embryonic stem cells, would transform regenerative medicine. However, despite global efforts, clinical applications remain a distant dream, due to associated factors such as genomic instability, tumorigenicity, immunogenicity, and heterogeneity. Meanwhile, the expression of embryonic (pluripotent) markers in multiple cancers has baffled the scientific community, and it has been suggested that somatic cells dedifferentiate and reprogram into the pluripotent state in vivo to initiate cancer. It has also been suggested that aging can be reversed by partial reprogramming in vivo. However, better methods are needed; using vectors or Yamanaka factors in vivo, for example, is dangerous, and many potential anti-aging therapies carry the same risks as those using induced pluripotent cells, as described above. The present perspective examines the potential of endogenous, pluripotent very small embryonic-like stem cells (VSELs). These cells are naturally present in multiple tissues; they routinely replace diseased tissue and ensure regeneration to maintain life-long homeostasis, and they have the ability to differentiate into adult counterparts. Recent evidence suggests that cancers initiate due to the selective expansion of epigenetically altered VSELs and their blocked differentiation. Furthermore, VSEL numbers have been directly linked to lifespan in studies of long- and short-lived transgenic mice, and VSEL dysfunction has been found in the ovaries of aged mice. To conclude, a greater interest in VSELs, with their potential to address all three fronts of this war, could be the light at the end of the tunnel." @default.
• W4313585546 created "2023-01-06" @default.
• W4313585546 creator A5028028831 @default.
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• W4313585546 creator A5062331398 @default.
• W4313585546 creator A5063899367 @default.
• W4313585546 date "2023-01-04" @default.
• W4313585546 modified "2023-10-18" @default.
• W4313585546 title "Very small embryonic-like stem cells have the potential to win the three-front war on tissue damage, cancer, and aging" @default.
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• W4313585546 doi "https://doi.org/10.3389/fcell.2022.1061022" @default.
• W4313585546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36684436" @default.
• W4313585546 hasPublicationYear "2023" @default.
• W4313585546 type Work @default.
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