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• W4313585902 abstract "Objective This study aims to compare the characteristics of early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) and non-ETP ALL patients and the outcomes of these patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Method A total of 57 patients with T-cell acute lymphoblastic leukemia/lymphoma receiving allo-HSCT at our center between January 2016 and March 2022 were enrolled in the study. Twenty-eight patients were diagnosed as ETP-ALL/LBL (28/57, 49.12%) in the cohort. Results The baseline characteristic was not significantly different between the two groups. The median time for myeloid engraftment was 14 days (ranged from 11 to 21) versus 14 days (ranged from 10 to 20) ( P = 0.067) and 18 days (ranged from 12 to 27) versus 15.5 days (ranged from 12 to 72) ( P = 0.183) for platelet engraftment in the ETP-ALL/LBL and non-ETP ALL groups, respectively. There was no significant difference in 5-year overall survival (54.74% ± 10.33% vs . 64.20% ± 10.30%, P = 0.786), relapse-free survival (56.22% ± 10.11% vs . 57.17% ± 12.71%, P = 0.841), cumulative incidence of relapse (30.14% ± 9.85% vs . 22.79% ± 8.24%, P = 0.774), and non-relapse mortality (19.52% ± 8.99% vs . 25.95% ± 14.44%, P = 0.967) between the two groups. The incidence of acute graft versus host disease (aGVHD) ( P = 0.922), II–IV aGVHD ( P = 0.940), III–IV aGVHD ( P = 0.664), cytomegalovirus infection ( P = 0.862), Epstein–Barr virus infection ( P = 0.610), and severe bacterial infection ( P = 0.145) was also similar. Conclusion The prognosis of patients with ETP-ALL/LBL was similar to non-ETP ALL patients when they received allo-HSCT." @default.
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• W4313585902 date "2023-01-04" @default.
• W4313585902 modified "2023-09-26" @default.
• W4313585902 title "Comparison of characteristics and outcomes on ETP-ALL/LBL and non-ETP ALL patients receiving allogeneic hematopoietic stem cell transplantation" @default.
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• W4313585902 doi "https://doi.org/10.3389/fonc.2022.1025885" @default.
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