Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313587309> ?p ?o ?g. }
- W4313587309 endingPage "156" @default.
- W4313587309 startingPage "156" @default.
- W4313587309 abstract "Aging processes, including immunosenescence, inflammation, inflammasome formation, genomic instability, telomeric attrition, and altered autophagy, are involved in viral infections and they may contribute to increased pathophysiological responses to the SARS-CoV-2 infection in the elderly; this poses additional risks of accelerated aging, which could be found even after recovery. Aging is associated with oxidative damage. Moreover, SARS-CoV-2 infections may increase the production of reactive oxygen species and such infections will disturb the Ca++ balance via an endoplasmic reticulum (ER) stress-mediated unfolded protein response. Although vaccine development and anti-inflammation therapy lower the severity of COVID-19, the prevalence and mortality rates are still alarming in some countries worldwide. In this review, we describe the involvement of viral proteins in activating ER stress transducers and their downstream signals and in inducing inflammation and inflammasome formation. Furthermore, we propose the potential of melatonin as an ER stress modulator, owing to its antioxidant, anti-inflammatory, and immunoregulatory effects in viral infections. Considering its strong safety profile, we suggest that additive melatonin supplementation in the elderly could be beneficial in treating COVID-19." @default.
- W4313587309 created "2023-01-06" @default.
- W4313587309 creator A5005381762 @default.
- W4313587309 creator A5008528850 @default.
- W4313587309 creator A5024578768 @default.
- W4313587309 creator A5040423746 @default.
- W4313587309 creator A5045238074 @default.
- W4313587309 creator A5073144245 @default.
- W4313587309 creator A5075292315 @default.
- W4313587309 creator A5079969784 @default.
- W4313587309 date "2023-01-04" @default.
- W4313587309 modified "2023-10-10" @default.
- W4313587309 title "Endoplasmic Reticulum Stress in Elderly Patients with COVID-19: Potential of Melatonin Treatment" @default.
- W4313587309 cites W1416364033 @default.
- W4313587309 cites W1573568265 @default.
- W4313587309 cites W1853052534 @default.
- W4313587309 cites W1901580941 @default.
- W4313587309 cites W1975915247 @default.
- W4313587309 cites W1987535382 @default.
- W4313587309 cites W1993688639 @default.
- W4313587309 cites W2002254994 @default.
- W4313587309 cites W2004083964 @default.
- W4313587309 cites W2023738340 @default.
- W4313587309 cites W2025216503 @default.
- W4313587309 cites W2029339804 @default.
- W4313587309 cites W2031509851 @default.
- W4313587309 cites W2031661979 @default.
- W4313587309 cites W2032051401 @default.
- W4313587309 cites W2032783993 @default.
- W4313587309 cites W2033023829 @default.
- W4313587309 cites W2033324724 @default.
- W4313587309 cites W2036701722 @default.
- W4313587309 cites W2037600884 @default.
- W4313587309 cites W2039689649 @default.
- W4313587309 cites W2044388785 @default.
- W4313587309 cites W2045009664 @default.
- W4313587309 cites W2052656918 @default.
- W4313587309 cites W2058058831 @default.
- W4313587309 cites W2058158581 @default.
- W4313587309 cites W2058599679 @default.
- W4313587309 cites W2059924886 @default.
- W4313587309 cites W2064138946 @default.
- W4313587309 cites W2065533930 @default.
- W4313587309 cites W2074259682 @default.
- W4313587309 cites W2078793932 @default.
- W4313587309 cites W2079663535 @default.
- W4313587309 cites W2081250015 @default.
- W4313587309 cites W2082402714 @default.
- W4313587309 cites W2085201901 @default.
- W4313587309 cites W2088988390 @default.
- W4313587309 cites W2089077392 @default.
- W4313587309 cites W2094875270 @default.
- W4313587309 cites W2105005820 @default.
- W4313587309 cites W2106248075 @default.
- W4313587309 cites W2109491705 @default.
- W4313587309 cites W2114144327 @default.
- W4313587309 cites W2126525177 @default.
- W4313587309 cites W2133644385 @default.
- W4313587309 cites W2135143264 @default.
- W4313587309 cites W2135256812 @default.
- W4313587309 cites W2137522359 @default.
- W4313587309 cites W2138065713 @default.
- W4313587309 cites W2142853998 @default.
- W4313587309 cites W2149766325 @default.
- W4313587309 cites W2155874562 @default.
- W4313587309 cites W2162679859 @default.
- W4313587309 cites W2162893658 @default.
- W4313587309 cites W2168704615 @default.
- W4313587309 cites W2168943979 @default.
- W4313587309 cites W2227929566 @default.
- W4313587309 cites W2285545553 @default.
- W4313587309 cites W2336451601 @default.
- W4313587309 cites W2345737547 @default.
- W4313587309 cites W2472765132 @default.
- W4313587309 cites W2516727366 @default.
- W4313587309 cites W2522054313 @default.
- W4313587309 cites W2567527531 @default.
- W4313587309 cites W2580419588 @default.
- W4313587309 cites W2616998305 @default.
- W4313587309 cites W2702831908 @default.
- W4313587309 cites W2766900039 @default.
- W4313587309 cites W2793350909 @default.
- W4313587309 cites W2793992104 @default.
- W4313587309 cites W2794250382 @default.
- W4313587309 cites W2799986334 @default.
- W4313587309 cites W2806777665 @default.
- W4313587309 cites W2885738092 @default.
- W4313587309 cites W2904342773 @default.
- W4313587309 cites W2905678967 @default.
- W4313587309 cites W2911043532 @default.
- W4313587309 cites W2921299578 @default.
- W4313587309 cites W2925300335 @default.
- W4313587309 cites W2937188981 @default.
- W4313587309 cites W2943222525 @default.
- W4313587309 cites W2945804322 @default.
- W4313587309 cites W2955284678 @default.
- W4313587309 cites W2962539274 @default.
- W4313587309 cites W2972334025 @default.