Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313588411> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4313588411 abstract "Purpose：Chronic corneal pain is the most common symptom of dry eye disease (DED), while the central sensitization mechanisms underlying remain unclear. Methods：Excision of extra orbital lacrimal glands was used to establish dry eye (DE) model. Tear volume measurements, corneal fluorescein staining, corneal hypersensitivity and anxiety behavior were tested after surgery. The amplitude of low-frequency fluctuation (ALFF) by fMRI was used for determining brain functional activity. C-Fos, Brain-derived neurotrophic factor (BDNF), and cytokine levels in corresponding brain regions were tested. Results：Compared to the Sham group, the ALFF signals in the supplemental somatosensory area, secondary auditory cortex, agranular insular cortex, temporal association areas, and ectorhinal cortex brain areas were enhanced in DE group. ALFF signal in the insular cortex was related to corneal hypersensitivity (p < 0.01). C-Fos (P < 0.001), BDNF (P < 0.01), TNF-α, IL-6 and IL-1β (P < 0.05) increased, while IL-10 levels (P < 0.05) decreased in the insular cortex in the DE group. Surgery-induced corneal hypersensitivity and upregulation of inflammatory cytokines, but not anxiety, could be blocked by insular cortex injection of Tyrosine Kinase receptor B (TrkB) agonist cyclotraxin-B (P< 0.01). Conclusions ：This research presents the map of functional brain by ALFF through rs-fMRI associated with chronic corneal pain. BDNF-TrkB signaling-related neuroinflammation in the insular cortex might contribute to dry eye-related chronic corneal pain. This measure could potentially help clinicians improve therapeutic approach to pain control and development of diagnostic approach." @default.
- W4313588411 created "2023-01-06" @default.
- W4313588411 creator A5007371559 @default.
- W4313588411 creator A5011349472 @default.
- W4313588411 creator A5016861429 @default.
- W4313588411 creator A5040786366 @default.
- W4313588411 creator A5042671636 @default.
- W4313588411 creator A5046779818 @default.
- W4313588411 creator A5047284901 @default.
- W4313588411 creator A5075558392 @default.
- W4313588411 creator A5078925242 @default.
- W4313588411 creator A5082309662 @default.
- W4313588411 date "2023-01-04" @default.
- W4313588411 modified "2023-09-26" @default.
- W4313588411 title "Brain Function Activity Changes and Contribution of Neuroinflammatory Factors in Insular Cortex of Mice with Dry Eye-Related Chronic Corneal Pain." @default.
- W4313588411 doi "https://doi.org/10.22541/au.167285905.53186769/v1" @default.
- W4313588411 hasPublicationYear "2023" @default.
- W4313588411 type Work @default.
- W4313588411 citedByCount "0" @default.
- W4313588411 crossrefType "posted-content" @default.
- W4313588411 hasAuthorship W4313588411A5007371559 @default.
- W4313588411 hasAuthorship W4313588411A5011349472 @default.
- W4313588411 hasAuthorship W4313588411A5016861429 @default.
- W4313588411 hasAuthorship W4313588411A5040786366 @default.
- W4313588411 hasAuthorship W4313588411A5042671636 @default.
- W4313588411 hasAuthorship W4313588411A5046779818 @default.
- W4313588411 hasAuthorship W4313588411A5047284901 @default.
- W4313588411 hasAuthorship W4313588411A5075558392 @default.
- W4313588411 hasAuthorship W4313588411A5078925242 @default.
- W4313588411 hasAuthorship W4313588411A5082309662 @default.
- W4313588411 hasBestOaLocation W43135884111 @default.
- W4313588411 hasConcept C126322002 @default.
- W4313588411 hasConcept C15744967 @default.
- W4313588411 hasConcept C160539049 @default.
- W4313588411 hasConcept C169760540 @default.
- W4313588411 hasConcept C170493617 @default.
- W4313588411 hasConcept C2777348757 @default.
- W4313588411 hasConcept C2780539906 @default.
- W4313588411 hasConcept C71924100 @default.
- W4313588411 hasConcept C97124661 @default.
- W4313588411 hasConceptScore W4313588411C126322002 @default.
- W4313588411 hasConceptScore W4313588411C15744967 @default.
- W4313588411 hasConceptScore W4313588411C160539049 @default.
- W4313588411 hasConceptScore W4313588411C169760540 @default.
- W4313588411 hasConceptScore W4313588411C170493617 @default.
- W4313588411 hasConceptScore W4313588411C2777348757 @default.
- W4313588411 hasConceptScore W4313588411C2780539906 @default.
- W4313588411 hasConceptScore W4313588411C71924100 @default.
- W4313588411 hasConceptScore W4313588411C97124661 @default.
- W4313588411 hasLocation W43135884111 @default.
- W4313588411 hasOpenAccess W4313588411 @default.
- W4313588411 hasPrimaryLocation W43135884111 @default.
- W4313588411 hasRelatedWork W1761493996 @default.
- W4313588411 hasRelatedWork W205881385 @default.
- W4313588411 hasRelatedWork W2088964232 @default.
- W4313588411 hasRelatedWork W2114058712 @default.
- W4313588411 hasRelatedWork W2158506678 @default.
- W4313588411 hasRelatedWork W2162390635 @default.
- W4313588411 hasRelatedWork W2748952813 @default.
- W4313588411 hasRelatedWork W2899084033 @default.
- W4313588411 hasRelatedWork W2941893136 @default.
- W4313588411 hasRelatedWork W4320038812 @default.
- W4313588411 isParatext "false" @default.
- W4313588411 isRetracted "false" @default.
- W4313588411 workType "article" @default.