FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313588531> ?p ?o ?g. }

• W4313588531 abstract "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a persistent negative impact on both the public health and the global economy. To comprehend the origin, transmission routes and discover the mutations that alter the virus’s transmissibility and pathogenicity, full-length SARS-CoV-2 genomes have to be molecularly characterized. Focusing on a two-year time frame (2020-2021), we provide an in-depth virologic and epidemiological overview of the SARS-CoV-2 pandemic in the Republic of North Macedonia by assessing the frequency and distribution of the circulating SARS-CoV-2 variants. Using genetic characterization and phylogenetic analysis we shed light on the molecular evolution of the virus as well as test for a possible connection between specific SARS-CoV-2 haplotypes and the severity of the clinical symptoms. Our results show that one fifth (21.51%) of the tested respiratory samples for SARS-CoV-2 were positive. A noticeable trend in the incidence and severity of the COVID-19 infections was observed in the 60+ age group between males and females. Of the total number of positive cases, the highest incidence of SARS-CoV-2 was noticed in 60+ males (4,170.4/100,000), with a statistically significant (0,0001) difference between the two sexes. Additionally, a 1.8x increase in male mortality and consequentially significantly higher number of death cases was observed compared to females of the same age group (0.001). A total of 327 samples were sequenced in the period March 2020 - August 2021, showing the temporal distribution of SARS-CoV-2 variants circulating in North Macedonia. The phylogenetic analysis showed that most of the viral genomes were closely related and clustered in four distinctive lineages, B.1, B.1.1.7, B.1.351 and B.1.617.2. A statistically significant difference was observed in the 2C_1 haplotype (p=0.0013), where 10.5% of the patients were hospitalized due to severe clinical condition. By employing genetic sequencing, coupled with epidemiological investigations, we investigated viral distribution patterns, identified emerging variants and detected vaccine breakthrough infections. The present work is the first molecular study giving a comprehensive overview of the genetic landscape of circulating SARS-CoV-2 viruses in North Macedonia in a period of two years." @default.
• W4313588531 created "2023-01-06" @default.
• W4313588531 creator A5008225392 @default.
• W4313588531 creator A5008727892 @default.
• W4313588531 creator A5014292136 @default.
• W4313588531 creator A5044196253 @default.
• W4313588531 creator A5058654124 @default.
• W4313588531 creator A5062389020 @default.
• W4313588531 creator A5066499432 @default.
• W4313588531 creator A5073101243 @default.
• W4313588531 creator A5078648045 @default.
• W4313588531 creator A5081071773 @default.
• W4313588531 creator A5081773437 @default.
• W4313588531 date "2023-01-04" @default.
• W4313588531 modified "2023-09-26" @default.
• W4313588531 title "In-depth genetic characterization of the SARS-CoV-2 pandemic in a two-year frame in North Macedonia using second and third generation sequencing technologies" @default.
• W4313588531 cites W1519765314 @default.
• W4313588531 cites W2110899053 @default.
• W4313588531 cites W2112490692 @default.
• W4313588531 cites W2137015675 @default.
• W4313588531 cites W2138618895 @default.
• W4313588531 cites W2605343262 @default.
• W4313588531 cites W2616925143 @default.
• W4313588531 cites W2789843538 @default.
• W4313588531 cites W2800303846 @default.
• W4313588531 cites W3001118548 @default.
• W4313588531 cites W3001897055 @default.
• W4313588531 cites W3012991084 @default.
• W4313588531 cites W3013093478 @default.
• W4313588531 cites W3016489853 @default.
• W4313588531 cites W3020188044 @default.
• W4313588531 cites W3020512604 @default.
• W4313588531 cites W3022687324 @default.
• W4313588531 cites W3030328305 @default.
• W4313588531 cites W3036178624 @default.
• W4313588531 cites W3121365103 @default.
• W4313588531 cites W3127385545 @default.
• W4313588531 cites W3129399011 @default.
• W4313588531 cites W3135383916 @default.
• W4313588531 cites W3137152384 @default.
• W4313588531 cites W3140446408 @default.
• W4313588531 cites W3142132699 @default.
• W4313588531 cites W3155952134 @default.
• W4313588531 cites W3156291144 @default.
• W4313588531 cites W3160600243 @default.
• W4313588531 cites W3170259192 @default.
• W4313588531 cites W3176449969 @default.
• W4313588531 cites W3181477365 @default.
• W4313588531 cites W3184075893 @default.
• W4313588531 cites W3185166128 @default.
• W4313588531 cites W3185488876 @default.
• W4313588531 cites W3193641425 @default.
• W4313588531 cites W3200299601 @default.
• W4313588531 cites W3203433659 @default.
• W4313588531 cites W3215580824 @default.
• W4313588531 cites W4205411121 @default.
• W4313588531 cites W4207077414 @default.
• W4313588531 cites W4220739689 @default.
• W4313588531 cites W4221057725 @default.
• W4313588531 cites W4225831292 @default.
• W4313588531 cites W4225882256 @default.
• W4313588531 cites W4281557772 @default.
• W4313588531 cites W4285007009 @default.
• W4313588531 cites W4285022127 @default.
• W4313588531 cites W4289261835 @default.
• W4313588531 cites W4293727224 @default.
• W4313588531 doi "https://doi.org/10.3389/fviro.2022.1064882" @default.
• W4313588531 hasPublicationYear "2023" @default.
• W4313588531 type Work @default.
• W4313588531 citedByCount "0" @default.
• W4313588531 crossrefType "journal-article" @default.
• W4313588531 hasAuthorship W4313588531A5008225392 @default.
• W4313588531 hasAuthorship W4313588531A5008727892 @default.
• W4313588531 hasAuthorship W4313588531A5014292136 @default.
• W4313588531 hasAuthorship W4313588531A5044196253 @default.
• W4313588531 hasAuthorship W4313588531A5058654124 @default.
• W4313588531 hasAuthorship W4313588531A5062389020 @default.
• W4313588531 hasAuthorship W4313588531A5066499432 @default.
• W4313588531 hasAuthorship W4313588531A5073101243 @default.
• W4313588531 hasAuthorship W4313588531A5078648045 @default.
• W4313588531 hasAuthorship W4313588531A5081071773 @default.
• W4313588531 hasAuthorship W4313588531A5081773437 @default.
• W4313588531 hasBestOaLocation W43135885311 @default.
• W4313588531 hasConcept C104317684 @default.
• W4313588531 hasConcept C107130276 @default.
• W4313588531 hasConcept C116675565 @default.
• W4313588531 hasConcept C119599485 @default.
• W4313588531 hasConcept C120665830 @default.
• W4313588531 hasConcept C121332964 @default.
• W4313588531 hasConcept C126322002 @default.
• W4313588531 hasConcept C127413603 @default.
• W4313588531 hasConcept C135763542 @default.
• W4313588531 hasConcept C159047783 @default.
• W4313588531 hasConcept C16683452 @default.
• W4313588531 hasConcept C197754878 @default.
• W4313588531 hasConcept C198394728 @default.
• W4313588531 hasConcept C2522874641 @default.
• W4313588531 hasConcept C2777648638 @default.
• W4313588531 hasConcept C2779134260 @default.
• W4313588531 hasConcept C3007834351 @default.

• next