Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313588810> ?p ?o ?g. }
- W4313588810 abstract "Introduction: Previous studies have reported that chromium (Cr)-induced epigenetic alterations and DNA methylation play a vital role in the pathogenesis of diseases induced by chromium exposure. Epigenomic analyses have been limited and mainly focused on occupational chromium exposure; their findings are not generalizable to populations with environmental Cr exposure. Methods: We identified the differential methylation of genes and regions to elucidate the mechanisms of toxicity related to environmental chromium exposure. DNA methylation was measured in blood samples collected from individuals in Cr-contaminated (n = 10) and unexposed areas (n = 10) by using the Illumina Infinium HumanMethylation850K array. To evaluate the relationship between chromium levels in urine and CpG methylation at 850 thousand sites, we investigated differentially methylated positions (DMPs) and differentially methylated regions (DMRs) by using linear models and DMRcate method, respectively. The model was adjusted for biologically relevant variables and estimated cell-type compositions. Results: At the epigenome-wide level, we identified five CpGs [cg20690919 (pFDR =0.006), cg00704664 (pFDR =0.024), cg10809143 (pFDR =0.043), cg27057652 (pFDR =0.047), cg05390480 (pFDR =0.024)] and one DMR (chr17: 19,648,718-19,648,972), annotated to ALDH3A1 genes (p < 0.05) as being significantly associated with log2 transformed urinary chromium levels. Discussion: Environmental chromium exposure is associated with DNA methylation, and the significant DMPs and DMR being annotated to cause DNA damage and genomic instability were found in this work. Research involving larger samples is required to further explore the epigenetic effect of environmental chromium exposure on health outcomes through DNA methylation." @default.
- W4313588810 created "2023-01-06" @default.
- W4313588810 creator A5010387831 @default.
- W4313588810 creator A5014078414 @default.
- W4313588810 creator A5014402234 @default.
- W4313588810 creator A5023496790 @default.
- W4313588810 creator A5025092478 @default.
- W4313588810 creator A5031487901 @default.
- W4313588810 creator A5037838582 @default.
- W4313588810 creator A5050789305 @default.
- W4313588810 creator A5059605240 @default.
- W4313588810 creator A5079069058 @default.
- W4313588810 date "2023-01-04" @default.
- W4313588810 modified "2023-09-25" @default.
- W4313588810 title "Association of environmental exposure to chromium with differential DNA methylation: An epigenome-wide study" @default.
- W4313588810 cites W1755052449 @default.
- W4313588810 cites W1968332094 @default.
- W4313588810 cites W1975311527 @default.
- W4313588810 cites W1978489297 @default.
- W4313588810 cites W1984807040 @default.
- W4313588810 cites W1989884334 @default.
- W4313588810 cites W1992040448 @default.
- W4313588810 cites W2005984678 @default.
- W4313588810 cites W2017899137 @default.
- W4313588810 cites W2029038413 @default.
- W4313588810 cites W2031834135 @default.
- W4313588810 cites W2037685278 @default.
- W4313588810 cites W2056040742 @default.
- W4313588810 cites W2060554250 @default.
- W4313588810 cites W2060559393 @default.
- W4313588810 cites W2065519410 @default.
- W4313588810 cites W2081502106 @default.
- W4313588810 cites W2083247246 @default.
- W4313588810 cites W2087505934 @default.
- W4313588810 cites W2100638481 @default.
- W4313588810 cites W2102323139 @default.
- W4313588810 cites W2104440905 @default.
- W4313588810 cites W2110065044 @default.
- W4313588810 cites W2121328000 @default.
- W4313588810 cites W2123929789 @default.
- W4313588810 cites W2130523009 @default.
- W4313588810 cites W2130883886 @default.
- W4313588810 cites W2134071049 @default.
- W4313588810 cites W2146512944 @default.
- W4313588810 cites W2149953341 @default.
- W4313588810 cites W2155070258 @default.
- W4313588810 cites W2155124369 @default.
- W4313588810 cites W2167826968 @default.
- W4313588810 cites W2169556367 @default.
- W4313588810 cites W2172203846 @default.
- W4313588810 cites W2529913104 @default.
- W4313588810 cites W2535214781 @default.
- W4313588810 cites W2616031005 @default.
- W4313588810 cites W2734909122 @default.
- W4313588810 cites W2739174192 @default.
- W4313588810 cites W2750633386 @default.
- W4313588810 cites W2791880553 @default.
- W4313588810 cites W2794823884 @default.
- W4313588810 cites W2795506072 @default.
- W4313588810 cites W2810417536 @default.
- W4313588810 cites W2899197098 @default.
- W4313588810 cites W2906064849 @default.
- W4313588810 cites W2909407563 @default.
- W4313588810 cites W2909764240 @default.
- W4313588810 cites W2913690744 @default.
- W4313588810 cites W2958812181 @default.
- W4313588810 cites W2978034960 @default.
- W4313588810 cites W3001277797 @default.
- W4313588810 cites W3022592625 @default.
- W4313588810 cites W3024120508 @default.
- W4313588810 cites W3038433315 @default.
- W4313588810 cites W3080161737 @default.
- W4313588810 cites W3107972991 @default.
- W4313588810 cites W3131184857 @default.
- W4313588810 cites W3139223686 @default.
- W4313588810 cites W3162286076 @default.
- W4313588810 cites W3167034701 @default.
- W4313588810 cites W3175903268 @default.
- W4313588810 cites W3194176616 @default.
- W4313588810 cites W3214343565 @default.
- W4313588810 cites W3215868980 @default.
- W4313588810 cites W4200319753 @default.
- W4313588810 cites W4205639024 @default.
- W4313588810 cites W4226102911 @default.
- W4313588810 doi "https://doi.org/10.3389/fgene.2022.1043486" @default.
- W4313588810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685967" @default.
- W4313588810 hasPublicationYear "2023" @default.
- W4313588810 type Work @default.
- W4313588810 citedByCount "0" @default.
- W4313588810 crossrefType "journal-article" @default.
- W4313588810 hasAuthorship W4313588810A5010387831 @default.
- W4313588810 hasAuthorship W4313588810A5014078414 @default.
- W4313588810 hasAuthorship W4313588810A5014402234 @default.
- W4313588810 hasAuthorship W4313588810A5023496790 @default.
- W4313588810 hasAuthorship W4313588810A5025092478 @default.
- W4313588810 hasAuthorship W4313588810A5031487901 @default.
- W4313588810 hasAuthorship W4313588810A5037838582 @default.
- W4313588810 hasAuthorship W4313588810A5050789305 @default.
- W4313588810 hasAuthorship W4313588810A5059605240 @default.
- W4313588810 hasAuthorship W4313588810A5079069058 @default.