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- W4313588844 abstract "Hepatocellular carcinoma (HCC) constitutes most primary liver cancers and is one of the most lethal and life-threatening malignancies globally. Unfortunately, a substantial proportion of HCC patients are identified at an advanced stage that is unavailable for curative surgery. Thus, palliative therapies represented by multi-tyrosine kinase inhibitors (TKIs) sorafenib remained the front-line treatment over the past decades. Recently, the application of immune checkpoint inhibitors (ICIs), especially targeting the PD-1/PD-L1/CTLA-4 axis, has achieved an inspiring clinical breakthrough for treating unresectable solid tumors. However, many HCC patients with poor responses lead to limited benefits in clinical applications, which has quickly drawn researchers’ attention to the regulatory mechanisms of immune checkpoints in HCC immune evasion. Evasion of immune surveillance by cancer is attributed to intricate reprogramming modulation in the tumor microenvironment. Currently, more and more studies have found that epigenetic modifications, such as chromatin structure remodeling, DNA methylation, histone post-translational modifications, and non-coding RNA levels, may contribute significantly to remodeling the tumor microenvironment to avoid immune clearance, affecting the efficacy of immunotherapy for HCC. This review summarizes the rapidly emerging progress of epigenetic-related changes during HCC resistance to ICIs and discusses the mechanisms of underlying epigenetic therapies available for surmounting immune resistance. Finally, we summarize the clinical advances in combining epigenetic therapies with immunotherapy, aiming to promote the formation of immune combination therapy strategies." @default.
- W4313588844 created "2023-01-06" @default.
- W4313588844 creator A5023380977 @default.
- W4313588844 creator A5047372742 @default.
- W4313588844 creator A5074113544 @default.
- W4313588844 creator A5075057807 @default.
- W4313588844 date "2023-01-04" @default.
- W4313588844 modified "2023-10-14" @default.
- W4313588844 title "Epigenetic modification-related mechanisms of hepatocellular carcinoma resistance to immune checkpoint inhibition" @default.
- W4313588844 cites W1498931318 @default.
- W4313588844 cites W1529159877 @default.
- W4313588844 cites W1549366169 @default.
- W4313588844 cites W1642362876 @default.
- W4313588844 cites W1744656122 @default.
- W4313588844 cites W1825553076 @default.
- W4313588844 cites W1863017422 @default.
- W4313588844 cites W1869249629 @default.
- W4313588844 cites W1900105756 @default.
- W4313588844 cites W1964368260 @default.
- W4313588844 cites W1967799787 @default.
- W4313588844 cites W1971837077 @default.
- W4313588844 cites W1972399803 @default.
- W4313588844 cites W1974747095 @default.
- W4313588844 cites W1975135992 @default.
- W4313588844 cites W1979187818 @default.
- W4313588844 cites W1983791607 @default.
- W4313588844 cites W1983908359 @default.
- W4313588844 cites W1990762796 @default.
- W4313588844 cites W1992034322 @default.
- W4313588844 cites W1994193851 @default.
- W4313588844 cites W2008933729 @default.
- W4313588844 cites W2012586673 @default.
- W4313588844 cites W2014038668 @default.
- W4313588844 cites W2017865707 @default.
- W4313588844 cites W2019436721 @default.
- W4313588844 cites W2029197798 @default.
- W4313588844 cites W2039307777 @default.
- W4313588844 cites W2040505605 @default.
- W4313588844 cites W2046100841 @default.
- W4313588844 cites W2049553585 @default.
- W4313588844 cites W2062759109 @default.
- W4313588844 cites W2064442490 @default.
- W4313588844 cites W2069054327 @default.
- W4313588844 cites W2095144242 @default.
- W4313588844 cites W2110676296 @default.
- W4313588844 cites W2121626779 @default.
- W4313588844 cites W2124302786 @default.
- W4313588844 cites W2125931439 @default.
- W4313588844 cites W2130324987 @default.
- W4313588844 cites W2136623765 @default.
- W4313588844 cites W2137187071 @default.
- W4313588844 cites W2147524392 @default.
- W4313588844 cites W2148779298 @default.
- W4313588844 cites W2151337762 @default.
- W4313588844 cites W2156353875 @default.
- W4313588844 cites W2167597760 @default.
- W4313588844 cites W2168589849 @default.
- W4313588844 cites W2194546364 @default.
- W4313588844 cites W2196447685 @default.
- W4313588844 cites W2198093519 @default.
- W4313588844 cites W2211837538 @default.
- W4313588844 cites W2273755799 @default.
- W4313588844 cites W2277004004 @default.
- W4313588844 cites W2293531514 @default.
- W4313588844 cites W2299181842 @default.
- W4313588844 cites W2323939601 @default.
- W4313588844 cites W2403874820 @default.
- W4313588844 cites W2435243879 @default.
- W4313588844 cites W2469758901 @default.
- W4313588844 cites W2470861509 @default.
- W4313588844 cites W2472631073 @default.
- W4313588844 cites W2515891388 @default.
- W4313588844 cites W2516788557 @default.
- W4313588844 cites W2535322499 @default.
- W4313588844 cites W2560367415 @default.
- W4313588844 cites W2560499218 @default.
- W4313588844 cites W2567564314 @default.
- W4313588844 cites W2572174216 @default.
- W4313588844 cites W2582362986 @default.
- W4313588844 cites W2606367731 @default.
- W4313588844 cites W2614910530 @default.
- W4313588844 cites W2622499649 @default.
- W4313588844 cites W2624831627 @default.
- W4313588844 cites W2626421530 @default.
- W4313588844 cites W2726751387 @default.
- W4313588844 cites W2747000876 @default.
- W4313588844 cites W2766201623 @default.
- W4313588844 cites W2772677509 @default.
- W4313588844 cites W2778217919 @default.
- W4313588844 cites W2782124401 @default.
- W4313588844 cites W2783333335 @default.
- W4313588844 cites W2785803176 @default.
- W4313588844 cites W2787358630 @default.
- W4313588844 cites W2794634849 @default.
- W4313588844 cites W2795334950 @default.
- W4313588844 cites W2802554884 @default.
- W4313588844 cites W2802645166 @default.
- W4313588844 cites W2803869134 @default.
- W4313588844 cites W2804448077 @default.
- W4313588844 cites W2805162488 @default.