FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313590198> ?p ?o ?g. }

• W4313590198 endingPage "83" @default.
• W4313590198 startingPage "63" @default.
• W4313590198 abstract "Runt-related transcription factor 3 (RUNX3) plays a pivotal role in tumor microenvironment and immune infiltration. However, the prognostic and immunological roles of RUNX3 in pancancer remain unclear. In the current study, we explored the expression profiles, prognostic landscape, and immune infiltration of RUNX3 in pancancer through a variety of online platforms, including HPA, ONCOMINE, UALCAN, GEPIA, PrognoScan, TCGA, TIMER, R2, and Reactome databases. In general, RUNX3 was widely expressed in tonsil, gallbladder, skin, spleen, lymph node, and bone marrow, and RUNX3 was frequently higher expression in tumor tissues compared to normal tissues. In prognostic analysis, the RUNX3 expression level was significantly correlated with the clinical outcomes of bladder cancer, blood cancer, brain cancer, breast cancer, colorectal cancer, lung cancer, and ovarian cancer. In mutation analysis, a total 72 mutation sites were located within amino acids 1 to 415 of RUNX3, including 65 missense sites and seven truncating sites, whereas the mutation frequency of skin cutaneous melanoma and uterine corpus endometrial carcinoma (UCEC) is relatively high (> 3%). In immune infiltration analysis, the RUNX3 expression level was significantly related to recognized markers and the immune infiltration levels of various types of immune cells in colon adenocarcinoma (COAD) and brain lower grade glioma (LGG). After that, 453 RUNX3 co-expressed genes were recognized in COAD, lymphoid neoplasm diffuse large B-cell lymphoma, LGG, and ovarian serous cystadenocarcinoma (OV). Pathway enrichment analysis revealed that RUNX3 co-expressed genes were remarkably enriched in immune system and tumor progression pathways. RUNX3 expression is associated with clinical prognosis, immune infiltration, and identified RUNX3 related pathways in a variety of tumors, which may serve as targets of promising prognostic markers and novel therapeutic targets for various human cancers." @default.
• W4313590198 created "2023-01-06" @default.
• W4313590198 creator A5030454606 @default.
• W4313590198 creator A5044331867 @default.
• W4313590198 creator A5051261153 @default.
• W4313590198 creator A5063783789 @default.
• W4313590198 date "2023-01-01" @default.
• W4313590198 modified "2023-10-01" @default.
• W4313590198 title "Multi-Omics Analysis of the Prognostic and Immunological Role of Runt-Related Transcription Factor 3 in Pan-Cancer" @default.
• W4313590198 cites W1557857141 @default.
• W4313590198 cites W1973624869 @default.
• W4313590198 cites W1984959227 @default.
• W4313590198 cites W2010241362 @default.
• W4313590198 cites W2048000549 @default.
• W4313590198 cites W2065451165 @default.
• W4313590198 cites W2069233757 @default.
• W4313590198 cites W2077110285 @default.
• W4313590198 cites W2082668371 @default.
• W4313590198 cites W2114843025 @default.
• W4313590198 cites W2125518385 @default.
• W4313590198 cites W2131110612 @default.
• W4313590198 cites W2132817788 @default.
• W4313590198 cites W2170147411 @default.
• W4313590198 cites W2212207931 @default.
• W4313590198 cites W2607129810 @default.
• W4313590198 cites W2609543331 @default.
• W4313590198 cites W2614794220 @default.
• W4313590198 cites W2616054334 @default.
• W4313590198 cites W2736730167 @default.
• W4313590198 cites W2749613778 @default.
• W4313590198 cites W2765224588 @default.
• W4313590198 cites W2783703728 @default.
• W4313590198 cites W2788596350 @default.
• W4313590198 cites W2792502228 @default.
• W4313590198 cites W2809534278 @default.
• W4313590198 cites W2920187808 @default.
• W4313590198 cites W2946343472 @default.
• W4313590198 cites W2963268653 @default.
• W4313590198 cites W2980333317 @default.
• W4313590198 cites W3026639275 @default.
• W4313590198 cites W3037873086 @default.
• W4313590198 cites W3128646645 @default.
• W4313590198 doi "https://doi.org/10.1615/critreveukaryotgeneexpr.2023044081" @default.
• W4313590198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37183947" @default.
• W4313590198 hasPublicationYear "2023" @default.
• W4313590198 type Work @default.
• W4313590198 citedByCount "1" @default.
• W4313590198 countsByYear W43135901982023 @default.
• W4313590198 crossrefType "journal-article" @default.
• W4313590198 hasAuthorship W4313590198A5030454606 @default.
• W4313590198 hasAuthorship W4313590198A5044331867 @default.
• W4313590198 hasAuthorship W4313590198A5051261153 @default.
• W4313590198 hasAuthorship W4313590198A5063783789 @default.
• W4313590198 hasConcept C121608353 @default.
• W4313590198 hasConcept C126322002 @default.
• W4313590198 hasConcept C142724271 @default.
• W4313590198 hasConcept C203014093 @default.
• W4313590198 hasConcept C2780427987 @default.
• W4313590198 hasConcept C2780849966 @default.
• W4313590198 hasConcept C502942594 @default.
• W4313590198 hasConcept C526805850 @default.
• W4313590198 hasConcept C530470458 @default.
• W4313590198 hasConcept C71924100 @default.
• W4313590198 hasConcept C86803240 @default.
• W4313590198 hasConcept C8891405 @default.
• W4313590198 hasConceptScore W4313590198C121608353 @default.
• W4313590198 hasConceptScore W4313590198C126322002 @default.
• W4313590198 hasConceptScore W4313590198C142724271 @default.
• W4313590198 hasConceptScore W4313590198C203014093 @default.
• W4313590198 hasConceptScore W4313590198C2780427987 @default.
• W4313590198 hasConceptScore W4313590198C2780849966 @default.
• W4313590198 hasConceptScore W4313590198C502942594 @default.
• W4313590198 hasConceptScore W4313590198C526805850 @default.
• W4313590198 hasConceptScore W4313590198C530470458 @default.
• W4313590198 hasConceptScore W4313590198C71924100 @default.
• W4313590198 hasConceptScore W4313590198C86803240 @default.
• W4313590198 hasConceptScore W4313590198C8891405 @default.
• W4313590198 hasIssue "4" @default.
• W4313590198 hasLocation W43135901981 @default.
• W4313590198 hasLocation W43135901982 @default.
• W4313590198 hasOpenAccess W4313590198 @default.
• W4313590198 hasPrimaryLocation W43135901981 @default.
• W4313590198 hasRelatedWork W1577314454 @default.
• W4313590198 hasRelatedWork W2118916537 @default.
• W4313590198 hasRelatedWork W2142300779 @default.
• W4313590198 hasRelatedWork W2160598672 @default.
• W4313590198 hasRelatedWork W2392730113 @default.
• W4313590198 hasRelatedWork W3004259476 @default.
• W4313590198 hasRelatedWork W3009386543 @default.
• W4313590198 hasRelatedWork W3039284339 @default.
• W4313590198 hasRelatedWork W3196332669 @default.
• W4313590198 hasRelatedWork W4237682097 @default.
• W4313590198 hasVolume "33" @default.
• W4313590198 isParatext "false" @default.
• W4313590198 isRetracted "false" @default.
• W4313590198 workType "article" @default.