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• W4313590466 abstract "Biomedical researchers use optical coherence microscopy (OCM) for its high resolution in real-time label-free tomographic imaging. However, OCM lacks bioactivity-related functional contrast. We developed an OCM system that can measure changes in intracellular motility (indicating cellular process states) via pixel-wise calculations of intensity fluctuations from metabolic activity of intracellular components. To reduce image noise, the source spectrum is split into five using Gaussian windows with 50% of the full bandwidth. The technique verified that F-actin fiber inhibition by Y-27632 reduces intracellular motility. This finding could be used to search for other intracellular-motility-associated therapeutic strategies for cardiovascular diseases." @default.
• W4313590466 created "2023-01-06" @default.
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• W4313590466 date "2023-01-04" @default.
• W4313590466 modified "2023-10-14" @default.
• W4313590466 title "Optical coherence microscopy with a split-spectrum image reconstruction method for temporal-dynamics contrast-based imaging of intracellular motility" @default.
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• W4313590466 doi "https://doi.org/10.1364/boe.478264" @default.
• W4313590466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36874497" @default.
• W4313590466 hasPublicationYear "2023" @default.
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